Gene Review:
SIX1 - SIX homeobox 1
Homo sapiens
Synonyms:
BOS3, DFNA23, Homeobox protein SIX1, Sine oculis homeobox homolog 1, TIP39
- SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Ruf, R.G., Xu, P.X., Silvius, D., Otto, E.A., Beekmann, F., Muerb, U.T., Kumar, S., Neuhaus, T.J., Kemper, M.J., Raymond, R.M., Brophy, P.D., Berkman, J., Gattas, M., Hyland, V., Ruf, E.M., Schwartz, C., Chang, E.H., Smith, R.J., Stratakis, C.A., Weil, D., Petit, C., Hildebrandt, F. Proc. Natl. Acad. Sci. U.S.A. (2004)
- The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis. Yu, Y., Davicioni, E., Triche, T.J., Merlino, G. Cancer Res. (2006)
- Gene amplification is a mechanism of Six1 overexpression in breast cancer. Reichenberger, K.J., Coletta, R.D., Schulte, A.P., Varella-Garcia, M., Ford, H.L. Cancer Res. (2005)
- Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators. Yu, Y., Khan, J., Khanna, C., Helman, L., Meltzer, P.S., Merlino, G. Nat. Med. (2004)
- Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation. Heanue, T.A., Reshef, R., Davis, R.J., Mardon, G., Oliver, G., Tomarev, S., Lassar, A.B., Tabin, C.J. Genes Dev. (1999)
- Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein. Ford, H.L., Landesman-Bollag, E., Dacwag, C.S., Stukenberg, P.T., Pardee, A.B., Seldin, D.C. J. Biol. Chem. (2000)
- Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development. Chai, L., Yang, J., Di, C., Cui, W., Kawakami, K., Lai, R., Ma, Y. J. Biol. Chem. (2006)
- Cloning of the human SIX1 gene and its assignment to chromosome 14. Boucher, C.A., Carey, N., Edwards, Y.H., Siciliano, M.J., Johnson, K.J. Genomics (1996)
- SIX1 Mutation Associated With Enlargement of the Vestibular Aqueduct in a Patient With Branchio-Oto Syndrome. Ito, T., Noguchi, Y., Yashima, T., Kitamura, K. Laryngoscope (2006)
- Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting system. Bush, K.T., Vaughn, D.A., Li, X., Rosenfeld, M.G., Rose, D.W., Mendoza, S.A., Nigam, S.K. Dev. Biol. (2006)
- Prevalence of Mutations in Renal Developmental Genes in Children with Renal Hypodysplasia: Results of the ESCAPE Study. Weber, S., Moriniere, V., Kn??ppel, T., Charbit, M., Dusek, J., Ghiggeri, G.M., Jankauskien??, A., Mir, S., Montini, G., Peco-Antic, A., W??hl, E., Zurowska, A.M., Mehls, O., Antignac, C., Schaefer, F., Salomon, R. J. Am. Soc. Nephrol. (2006)
- Identification of a novel EYA1 splice-site mutation in a Danish branchio-oto-renal syndrome family. Henriksen, A.M., Tümer, Z., Tommerup, N., Tranebjaerg, L., Larsen, L.A. Genet. Test. (2004)
- Deletion at 14q22-23 indicates a contiguous gene syndrome comprising anophthalmia, pituitary hypoplasia, and ear anomalies. Nolen, L.D., Amor, D., Haywood, A., St Heaps, L., Willcock, C., Mihelec, M., Tam, P., Billson, F., Grigg, J., Peters, G., Jamieson, R.V. Am. J. Med. Genet. A (2006)
- The Sine oculis/Six class family of homeobox genes in jellyfish with and without eyes: development and eye regeneration. Stierwald, M., Yanze, N., Bamert, R.P., Kammermeier, L., Schmid, V. Dev. Biol. (2004)
- EYA1 and SIX1 gene mutations in Japanese patients with branchio-oto-renal (BOR) syndrome and related conditions. Okada, M., Fujimaru, R., Morimoto, N., Satomura, K., Kaku, Y., Tsuzuki, K., Nozu, K., Okuyama, T., Iijima, K. Pediatr. Nephrol. (2006)
- Clinicopathological significance of homeoprotein Six1 in hepatocellular carcinoma. Ng, K.T., Man, K., Sun, C.K., Lee, T.K., Poon, R.T., Lo, C.M., Fan, S.T. Br. J. Cancer (2006)