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Gene Review

PLA2G5  -  phospholipase A2, group V

Homo sapiens

Synonyms: Calcium-dependent phospholipase A2, FRFB, GV-PLA2, Group V phospholipase A2, PLA2-10, ...
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High impact information on PLA2G5


Biological context of PLA2G5


Anatomical context of PLA2G5


Associations of PLA2G5 with chemical compounds


Analytical, diagnostic and therapeutic context of PLA2G5

  • The GV-PLA2 cDNA was synthesized from human heart polyA+ mRNA by RT-PCR, and an expression construct containing the GV-PLA2 was established [5].


  1. Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils. Muñoz, N.M., Meliton, A.Y., Lambertino, A., Boetticher, E., Learoyd, J., Sultan, F., Zhu, X., Cho, W., Leff, A.R. J. Immunol. (2006) [Pubmed]
  2. Group V phospholipase A2 induces leukotriene biosynthesis in human neutrophils through the activation of group IVA phospholipase A2. Kim, Y.J., Kim, K.P., Han, S.K., Munoz, N.M., Zhu, X., Sano, H., Leff, A.R., Cho, W. J. Biol. Chem. (2002) [Pubmed]
  3. Roles of Trp31 in high membrane binding and proinflammatory activity of human group V phospholipase A2. Han, S.K., Kim, K.P., Koduri, R., Bittova, L., Munoz, N.M., Leff, A.R., Wilton, D.C., Gelb, M.H., Cho, W. J. Biol. Chem. (1999) [Pubmed]
  4. Activation of phospholipase A2 is associated with generation of placental lipid signals and fetal obesity. Varastehpour, A., Radaelli, T., Minium, J., Ortega, H., Herrera, E., Catalano, P., Hauguel-de Mouzon, S. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  5. Expression and characterization of human group V phospholipase A2. Chen, Y., Dennis, E.A. Biochim. Biophys. Acta (1998) [Pubmed]
  6. Effect of tryptophan insertions on the properties of the human group IIA phospholipase A2: mutagenesis produces an enzyme with characteristics similar to those of the human group V phospholipase A2. Beers, S.A., Buckland, A.G., Giles, N., Gelb, M.H., Wilton, D.C. Biochemistry (2003) [Pubmed]
  7. Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils. Muñoz, N.M., Kim, Y.J., Meliton, A.Y., Kim, K.P., Han, S.K., Boetticher, E., O'Leary, E., Myou, S., Zhu, X., Bonventre, J.V., Leff, A.R., Cho, W. J. Biol. Chem. (2003) [Pubmed]
  8. Mechanism of human group V phospholipase A2 (PLA2)-induced leukotriene biosynthesis in human neutrophils. A potential role of heparan sulfate binding in PLA2 internalization and degradation. Kim, K.P., Rafter, J.D., Bittova, L., Han, S.K., Snitko, Y., Munoz, N.M., Leff, A.R., Cho, W. J. Biol. Chem. (2001) [Pubmed]
  9. Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study. Wootton, P.T., Arora, N.L., Drenos, F., Thompson, S.R., Cooper, J.A., Stephens, J.W., Hurel, S.J., Hurt-Camejo, E., Wiklund, O., Humphries, S.E., Talmud, P.J. Hum. Mol. Genet. (2007) [Pubmed]
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