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Gene Review

CLIC5  -  chloride intracellular channel 5

Homo sapiens

Synonyms: Chloride intracellular channel protein 5, DFNB102, DFNB103, MST130, MSTP130
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High impact information on CLIC5


Anatomical context of CLIC5

  • In wild-type mice, CLIC5-specific immunofluorescence was detected in stereocilia of both cochlear and vestibular hair cells and also along the apical surface of Kolliker's organ during cochlear development [3].
  • These results suggest that CLIC5 associates with radixin in hair cell stereocilia and may help form or stabilize connections between the plasma membrane and the filamentous actin core [3].
  • By mass spectrometry and immunoblotting, CLIC5 was shown to be expressed at high levels in stereocilia of the chicken utricle, in an approximate 1:1 molar ratio with radixin [3].

Associations of CLIC5 with chemical compounds


Analytical, diagnostic and therapeutic context of CLIC5


  1. AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member. Shanks, R.A., Larocca, M.C., Berryman, M., Edwards, J.C., Urushidani, T., Navarre, J., Goldenring, J.R. J. Biol. Chem. (2002) [Pubmed]
  2. Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. Berryman, M., Bretscher, A. Mol. Biol. Cell (2000) [Pubmed]
  3. The chloride intracellular channel protein CLIC5 is expressed at high levels in hair cell stereocilia and is essential for normal inner ear function. Gagnon, L.H., Longo-Guess, C.M., Berryman, M., Shin, J.B., Saylor, K.W., Yu, H., Gillespie, P.G., Johnson, K.R. J. Neurosci. (2006) [Pubmed]
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