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Gene Review

Skap2  -  src family associated phosphoprotein 2

Mus musculus

Synonyms: 2610021A10Rik, AA960083, BB137539, Prap, Pyk2/RAFTK-associated protein, ...
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Disease relevance of Skap2


High impact information on Skap2


Biological context of Skap2

  • In addition, we obtained evidence that SKAP-HOM is tyrosine phosphorylated in response to macrophage cell adhesion and that it forms a signalling complex with Fyb [3].
  • We conclude that although Saps were produced, individual Saps were not indispensable factors for virulence during gastrointestinal infection of mice [4].

Anatomical context of Skap2

  • In summary, our data suggest that SKAP-HOM is required for proper activation of the immune system, likely by regulating the cross-talk between immunoreceptors and integrins [1].
  • Induced myeloid differentiation of M1 and HL-60 cell lines was associated with an eight-fold increase in mSKAP55R mRNA [2].
  • Enforced expression of mSKAP55R inhibited in vitro growth of the myeloid FDC-P1 cell line and primary hematopoietic progenitors [2].
  • Individual acid aspartic proteinases (Saps) 1-6 of Candida albicans are not essential for invasion and colonization of the gastrointestinal tract in mice [4].
  • Furthermore, Vac1p affects chlamydospore formation, adherence to human vaginal epithelial cells, and the secretion of aspartyl proteinases (Saps) [5].


  1. Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM. Togni, M., Swanson, K.D., Reimann, S., Kliche, S., Pearce, A.C., Simeoni, L., Reinhold, D., Wienands, J., Neel, B.G., Schraven, B., Gerber, A. Mol. Cell. Biol. (2005) [Pubmed]
  2. Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest. Curtis, D.J., Jane, S.M., Hilton, D.J., Dougherty, L., Bodine, D.M., Begley, C.G. Exp. Hematol. (2000) [Pubmed]
  3. The Yersinia tyrosine phosphatase YopH targets a novel adhesion-regulated signalling complex in macrophages. Black, D.S., Marie-Cardine, A., Schraven, B., Bliska, J.B. Cell. Microbiol. (2000) [Pubmed]
  4. Individual acid aspartic proteinases (Saps) 1-6 of Candida albicans are not essential for invasion and colonization of the gastrointestinal tract in mice. Kretschmar, M., Felk, A., Staib, P., Schaller, M., Hess, D., Callapina, M., Morschhäuser, J., Schäfer, W., Korting, H.C., Hof, H., Hube, B., Nichterlein, T. Microb. Pathog. (2002) [Pubmed]
  5. The vesicle transport protein Vac1p is required for virulence of Candida albicans. Franke, K., Nguyen, M., H??rtl, A., Dahse, H.M., Vogl, G., W??rzner, R., Zipfel, P.F., K??nkel, W., Eck, R. Microbiology (Reading, Engl.) (2006) [Pubmed]
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