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Gene Review

Fyb  -  FYN binding protein

Mus musculus

Synonyms: ADAP, Adhesion and degranulation promoting adaptor protein, B630013F22Rik, FYB-120/130, FYN-T-binding protein, ...
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Disease relevance of Fyb


Psychiatry related information on Fyb

  • The beads were coated with polyclonal IgG purified from sera obtained from rabbits immunized with a highly enriched Alzheimer's disease brain protein fraction for ADAP [2].

High impact information on Fyb


Chemical compound and disease context of Fyb


Biological context of Fyb


Anatomical context of Fyb

  • Characterization of signaling molecules such as SLP-76, SLAM, SAP, and Fyb in the mucosal immune system will be an important area of future research [11].
  • Previously, several groups have provided experimental evidence that SKAP-HOM (most likely in cooperation with the cytosolic adaptor protein ADAP) is involved in regulating leukocyte adhesion [12].
  • Surprisingly, we found that mast cells lacking ADAP expression demonstrate no defects in FcepsilonRI-induced adhesion, granule release, or IL-6 production, and that ADAP-deficient mice produce a normal passive systemic anaphylactic response [8].
  • ADAP was found to be expressed in cells at the prefusion stage and localized mainly in the leading edge of lamellipodia and in pseudopodia [9].
  • In this study, we searched for c-Src-binding proteins using a combination of pull-down assays and mass spectrometric analysis, and identified the association of adhesion and degranulation promoting adaptor protein (ADAP) with c-Src in RAW264 cells and osteoclast precursors prepared from bone marrow cells [9].

Associations of Fyb with chemical compounds


Physical interactions of Fyb

  • We show that mAbp1 binds the Fyb N-terminal via its C-terminally located src homology 3 domain [1].

Regulatory relationships of Fyb

  • Physical and functional association of c-Src and adhesion and degranulation promoting adaptor protein (ADAP) in osteoclastogenesis in vitro [9].

Other interactions of Fyb

  • Hence, mAbp1 is likely to constitute a downstream effector of Fyb involved in F-actin dynamics [1].
  • This work identifies SLP-76 as an important adapter molecule that is regulated by Syk and lies upstream of SLAP-130 and PLC-gamma2 in CRP-stimulated platelets [15].
  • We demonstrate here that two major MIST-associated phosphoproteins expressed in mast cell lines are SLAP-130 and SKAP55, adaptors known to interact with the Src-homology (SH) 2 domain of Src-family protein tyrosine kinases (PTKs) [16].
  • MIST directly associated with SLAP-130 via its SH2 domain, and collaboration of SLAP-130 with SKAP55 was required for the recruitment of MIST to Lyn [16].
  • Analysis of ligand bound per cell demonstrated no significant difference in binding of erythrocyte antibodies to platelets from donors homozygous, heterozygous, or negative for D, C, c, E, e, Fya, Fyb, Jka, Jkb , K, k, and Lub antigens [17].


  1. Fyn binding protein, Fyb, interacts with mammalian actin binding protein, mAbp1. Yuan, M., Mogemark, L., Fällman, M. FEBS Lett. (2005) [Pubmed]
  2. A sandwich enzyme immunoassay for detecting and measuring Alzheimer's disease--associated proteins in human brain tissue. Ghanbari, H.A., Kozuk, T., Miller, B.E., Riesing, S. J. Clin. Lab. Anal. (1990) [Pubmed]
  3. Coupling of the TCR to integrin activation by Slap-130/Fyb. Peterson, E.J., Woods, M.L., Dmowski, S.A., Derimanov, G., Jordan, M.S., Wu, J.N., Myung, P.S., Liu, Q.H., Pribila, J.T., Freedman, B.D., Shimizu, Y., Koretzky, G.A. Science (2001) [Pubmed]
  4. Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Griffiths, E.K., Krawczyk, C., Kong, Y.Y., Raab, M., Hyduk, S.J., Bouchard, D., Chan, V.S., Kozieradzki, I., Oliveira-Dos-Santos, A.J., Wakeham, A., Ohashi, P.S., Cybulsky, M.I., Rudd, C.E., Penninger, J.M. Science (2001) [Pubmed]
  5. ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation. Wang, H., McCann, F.E., Gordan, J.D., Wu, X., Raab, M., Malik, T.H., Davis, D.M., Rudd, C.E. J. Exp. Med. (2004) [Pubmed]
  6. Interaction between the Yersinia tyrosine phosphatase YopH and its macrophage substrate, Fyn-binding protein, Fyb. Yuan, M., Deleuil, F., Fällman, M. J. Mol. Microbiol. Biotechnol. (2005) [Pubmed]
  7. ADAP is required for normal {alpha}IIb{beta}3 activation by VWF/GP Ib-IX-V and other agonists. Kasirer-Friede, A., Moran, B., Nagrampa-Orje, J., Swanson, K., Ruggeri, Z.M., Schraven, B., Neel, B.G., Koretzky, G., Shattil, S.J. Blood (2007) [Pubmed]
  8. Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell function. Wu, J.N., Jordan, M.S., Silverman, M.A., Peterson, E.J., Koretzky, G.A. J. Immunol. (2004) [Pubmed]
  9. Physical and functional association of c-Src and adhesion and degranulation promoting adaptor protein (ADAP) in osteoclastogenesis in vitro. Koga, S., Yogo, K., Yoshikawa, K., Samori, H., Goto, M., Uchida, T., Ishida, N., Takeya, T. J. Biol. Chem. (2005) [Pubmed]
  10. The Yersinia tyrosine phosphatase YopH targets a novel adhesion-regulated signalling complex in macrophages. Black, D.S., Marie-Cardine, A., Schraven, B., Bliska, J.B. Cell. Microbiol. (2000) [Pubmed]
  11. Meeting summary: Signal transduction pathways in immune and inflammatory cells. November 30-December 3, 2000, Amelia Island, Florida, U.S.A. Plevy, S., Mayer, L. Inflamm. Bowel Dis. (2003) [Pubmed]
  12. Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM. Togni, M., Swanson, K.D., Reimann, S., Kliche, S., Pearce, A.C., Simeoni, L., Reinhold, D., Wienands, J., Neel, B.G., Schraven, B., Gerber, A. Mol. Cell. Biol. (2005) [Pubmed]
  13. Glycoprotein VI/Fc receptor gamma chain-independent tyrosine phosphorylation and activation of murine platelets by collagen. Jarvis, G.E., Best, D., Watson, S.P. Biochem. J. (2004) [Pubmed]
  14. Use of the MAIEA assay to demonstrate that Fy3 is on the same glycoprotein as Fy6, Fya, and Fyb. Tzeng, J., Dodd, R., Mallory, D. Immunohematology / American Red Cross. (1998) [Pubmed]
  15. Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. Gross, B.S., Lee, J.R., Clements, J.L., Turner, M., Tybulewicz, V.L., Findell, P.R., Koretzky, G.A., Watson, S.P. J. Biol. Chem. (1999) [Pubmed]
  16. Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells. Fujii, Y., Wakahara, S., Nakao, T., Hara, T., Ohtake, H., Komurasaki, T., Kitamura, K., Tatsuno, A., Fujiwara, N., Hozumi, N., Ra, C., Kitamura, D., Goitsuka, R. FEBS Lett. (2003) [Pubmed]
  17. Erythrocyte antigens on human platelets. Absence of Rh, Duffy, Kell, Kidd, and Lutheran antigens. Dunstan, R.A., Simpson, M.B., Rosse, W.F. Transfusion (1984) [Pubmed]
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