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ING1  -  inhibitor of growth family, member 1

Homo sapiens

Synonyms: p24ING1c, p33, p33ING1, p33ING1b, p47, ...
 
 
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Disease relevance of ING1

 

High impact information on ING1

 

Chemical compound and disease context of ING1

  • Potential new probiotic strains Lactobacillus brevis PELI, L. reuteri ING1, L. rhamnosus VTT E-800 and L. rhamnosus LC-705 were assessed for their adhesion properties using the human intestinal mucus model [7].
  • MATERIALS AND METHODS: Various malignant brain tumor cell lines were examined for their sensitivity to cisplatin, doxorubicin, etoposide and the antimitotic agents vincristine and paclitaxel by MTT-cytotoxicity assays. p33ING1 mRNA expression was determined by RT-PCR [8].
 

Biological context of ING1

 

Anatomical context of ING1

  • Here we present the first report of ING1 expression and mutation analyses in human brain tumor samples and malignant glioma cell lines [2].
  • Chronic expression of antisense ING1 RNA reproducibly resulted in extension of the proliferative life span of normal human fibroblasts by approximately seven population doublings [12].
  • UV induction of ING1 in keratinocytes suggests that ING1 may play a role in cellular stress response and skin carcinogenesis [13].
  • Reduced expression of the two major alternatively spliced ING1 messenger RNA variants, p47(ING1a) and p33(ING1b) was variable, but was reduced (1.2-10-fold) in 12 of 19 AdEGJs compared to normal esophageal epithelium [14].
  • We found decreased expression of ING1 mRNA in 4 of 5 T-cell lines and 5 of 11 B-cell lines including two Burkitt lymphomas and two myelomas [15].
 

Associations of ING1 with chemical compounds

 

Physical interactions of ING1

  • ING1 represses transcription by direct DNA binding and through effects on p53 [21].
  • The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b [22].
 

Regulatory relationships of ING1

 

Other interactions of ING1

 

Analytical, diagnostic and therapeutic context of ING1

References

  1. Identification of the p33(ING1)-regulated genes that include cyclin B1 and proto-oncogene DEK by using cDNA microarray in a mouse mammary epithelial cell line NMuMG. Takahashi, M., Seki, N., Ozaki, T., Kato, M., Kuno, T., Nakagawa, T., Watanabe, K., Miyazaki, K., Ohira, M., Hayashi, S., Hosoda, M., Tokita, H., Mizuguchi, H., Hayakawa, T., Todo, S., Nakagawara, A. Cancer Res. (2002) [Pubmed]
  2. Altered subcellular localization and low frequency of mutations of ING1 in human brain tumors. Vieyra, D., Senger, D.L., Toyama, T., Muzik, H., Brasher, P.M., Johnston, R.N., Riabowol, K., Forsyth, P.A., Toyam, T. Clin. Cancer Res. (2003) [Pubmed]
  3. Mutations of the ING1 tumor suppressor gene detected in human melanoma abrogate nucleotide excision repair. Campos, E.I., Martinka, M., Mitchell, D.L., Dai, D.L., Li, G. Int. J. Oncol. (2004) [Pubmed]
  4. Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation. Garkavtsev, I., Kazarov, A., Gudkov, A., Riabowol, K. Nat. Genet. (1996) [Pubmed]
  5. The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control. Garkavtsev, I., Grigorian, I.A., Ossovskaya, V.S., Chernov, M.V., Chumakov, P.M., Gudkov, A.V. Nature (1998) [Pubmed]
  6. Different HATS of the ING1 gene family. Feng, X., Hara, Y., Riabowol, K. Trends Cell Biol. (2002) [Pubmed]
  7. Assessment of adhesion properties of novel probiotic strains to human intestinal mucus. Ouwehand, A.C., Tuomola, E.M., Tölkkö, S., Salminen, S. Int. J. Food Microbiol. (2001) [Pubmed]
  8. Expression of p33ING1 mRNA and chemosensitivity in brain tumor cells. Tallen, G., Riabowol, K., Wolff, J.E. Anticancer Res. (2003) [Pubmed]
  9. Human ING1 proteins differentially regulate histone acetylation. Vieyra, D., Loewith, R., Scott, M., Bonnefin, P., Boisvert, F.M., Cheema, P., Pastyryeva, S., Meijer, M., Johnston, R.N., Bazett-Jones, D.P., McMahon, S., Cole, M.D., Young, D., Riabowol, K. J. Biol. Chem. (2002) [Pubmed]
  10. UV-induced binding of ING1 to PCNA regulates the induction of apoptosis. Scott, M., Bonnefin, P., Vieyra, D., Boisvert, F.M., Young, D., Bazett-Jones, D.P., Riabowol, K. J. Cell. Sci. (2001) [Pubmed]
  11. Function of the ING family of PHD proteins in cancer. Gong, W., Suzuki, K., Russell, M., Riabowol, K. Int. J. Biochem. Cell Biol. (2005) [Pubmed]
  12. Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor. Garkavtsev, I., Riabowol, K. Mol. Cell. Biol. (1997) [Pubmed]
  13. Expression of the novel tumour suppressor p33(ING1)is independent of p53. Cheung, K.J., Bush, J.A., Jia, W., Li, G. Br. J. Cancer (2000) [Pubmed]
  14. ING1 and p53 tumor suppressor gene alterations in adenocarcinomas of the esophagogastric junction. Hara, Y., Zheng, Z., Evans, S.C., Malatjalian, D., Riddell, D.C., Guernsey, D.L., Wang, L.D., Riabowol, K., Casson, A.G. Cancer Lett. (2003) [Pubmed]
  15. Decreased expression of p33ING1 mRNA in lymphoid malignancies. Ohmori, M., Nagai, M., Tasaka, T., Koeffler, H.P., Toyama, T., Riabowol, K., Takahara, J. Am. J. Hematol. (1999) [Pubmed]
  16. A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis. Helbing, C.C., Veillette, C., Riabowol, K., Johnston, R.N., Garkavtsev, I. Cancer Res. (1997) [Pubmed]
  17. Solution structure and NMR characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ING4. Palacios, A., Garcia, P., Padr??, D., L??pez-Hern??ndez, E., Mart??n, I., Blanco, F.J. FEBS Lett. (2006) [Pubmed]
  18. Epigenetic and genetic alterations of p33ING1b in ovarian cancer. Shen, D.H., Chan, K.Y., Khoo, U.S., Ngan, H.Y., Xue, W.C., Chiu, P.M., Ip, P., Cheung, A.N. Carcinogenesis (2005) [Pubmed]
  19. The tumour suppressor p33ING1 does not enhance camptothecin-induced cell death in melanoma cells. Cheung, K.J., Li, G. Int. J. Oncol. (2002) [Pubmed]
  20. p33ING1b and estrogen receptor (ER) alpha. Toyama, T., Iwase, H. Breast Cancer (2004) [Pubmed]
  21. ING1 represses transcription by direct DNA binding and through effects on p53. Kataoka, H., Bonnefin, P., Vieyra, D., Feng, X., Hara, Y., Miura, Y., Joh, T., Nakabayashi, H., Vaziri, H., Harris, C.C., Riabowol, K. Cancer Res. (2003) [Pubmed]
  22. The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b. Simpson, F., Lammerts van Bueren, K., Butterfield, N., Bennetts, J.S., Bowles, J., Adolphe, C., Simms, L.A., Young, J., Walsh, M.D., Leggett, B., Fowles, L.F., Wicking, C. Exp. Cell Res. (2006) [Pubmed]
  23. The novel tumour suppressor gene ING1 is overexpressed in human melanoma cell lines. Campos, E.I., Cheung, K.J., Murray, A., Li, S., Li, G. Br. J. Dermatol. (2002) [Pubmed]
  24. Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). Kuzmichev, A., Zhang, Y., Erdjument-Bromage, H., Tempst, P., Reinberg, D. Mol. Cell. Biol. (2002) [Pubmed]
  25. Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. Skowyra, D., Zeremski, M., Neznanov, N., Li, M., Choi, Y., Uesugi, M., Hauser, C.A., Gu, W., Gudkov, A.V., Qin, J. J. Biol. Chem. (2001) [Pubmed]
  26. Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene. Jäger, D., Stockert, E., Scanlan, M.J., Güre, A.O., Jäger, E., Knuth, A., Old, L.J., Chen, Y.T. Cancer Res. (1999) [Pubmed]
  27. Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas. Gunduz, M., Nagatsuka, H., Demircan, K., Gunduz, E., Cengiz, B., Ouchida, M., Tsujigiwa, H., Yamachika, E., Fukushima, K., Beder, L., Hirohata, S., Ninomiya, Y., Nishizaki, K., Shimizu, K., Nagai, N. Gene (2005) [Pubmed]
  28. Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers. Tokunaga, E., Maehara, Y., Oki, E., Kitamura, K., Kakeji, Y., Ohno, S., Sugimachi, K. Cancer Lett. (2000) [Pubmed]
  29. Analyses of the tumour suppressor ING1 expression and gene mutation in human basal cell carcinoma. Chen, B., Campos, E.I., Crawford, R., Martinka, M., Li, G. Int. J. Oncol. (2003) [Pubmed]
 
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