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Gene Review

ING2  -  inhibitor of growth family, member 2

Homo sapiens

Synonyms: ING1L, ING1Lp, Inhibitor of growth 1-like protein, Inhibitor of growth protein 2, p32, ...
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Disease relevance of ING2

  • Nuclear ING2 expression is reduced in human cutaneous melanomas [1].
  • Our data showed that nuclear ING2 expression was significantly reduced in radial growth phase (RGP), vertical growth phase (VGP), and metastatic melanomas compared with dysplastic nevi (P < 0.05) [1].
  • Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes [2].
  • In addition, we found that p33ING2 is an essential factor for UV-induced rapid histone H4 acetylation, chromatin relaxation, and the recruitment of damage recognition protein, xeroderma pigmentosum group A protein, to the photolesions [3].
  • Although the significance of this observation with respect to carcinogenesis remains to be established, the data suggest that ING1L might be involved in colon cancers through interference with signal(s) transmitted through p53 and p33(ING1) [4].

High impact information on ING2


Biological context of ING2


Anatomical context of ING2


Associations of ING2 with chemical compounds

  • ING2 protein expression increased in late-passage human primary cells, and it colocalizes with serine 15-phosphorylated p53 [8].
  • The family of proteins inhibitors of growth (ING) contains a PHD finger that bind to histone-3 trimethylated at lysine 4, and those of ING1 and ING2 also act as nuclear phosphoinositide receptors [9].

Regulatory relationships of ING2

  • Knockdown of endogenous SnoN blocks the ability of ING2 to promote TGF-beta-dependent transcription, and conversely expression of SnoN augments ING2 enhancement of the TGF-beta response [11].

Other interactions of ING2


Analytical, diagnostic and therapeutic context of ING2


  1. Nuclear ING2 expression is reduced in human cutaneous melanomas. Lu, F., Dai, D.L., Martinka, M., Ho, V., Li, G. Br. J. Cancer (2006) [Pubmed]
  2. Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes. Sironi, E., Cerri, A., Tomasini, D., Sirchia, S.M., Porta, G., Rossella, F., Grati, F.R., Simoni, G. J. Cutan. Pathol. (2004) [Pubmed]
  3. The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation. Wang, J., Chin, M.Y., Li, G. Cancer Res. (2006) [Pubmed]
  4. Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor. Shimada, Y., Saito, A., Suzuki, M., Takahashi, E., Horie, M. Cytogenet. Cell Genet. (1998) [Pubmed]
  5. Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta. Jones, D.R., Bultsma, Y., Keune, W.J., Halstead, J.R., Elouarrat, D., Mohammed, S., Heck, A.J., D'Santos, C.S., Divecha, N. Mol. Cell (2006) [Pubmed]
  6. Specific sequence changes in multiple transcript system DYT3 are associated with X-linked dystonia parkinsonism. Nolte, D., Niemann, S., Müller, U. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. Nagashima, M., Shiseki, M., Miura, K., Hagiwara, K., Linke, S.P., Pedeux, R., Wang, X.W., Yokota, J., Riabowol, K., Harris, C.C. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  8. ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. Pedeux, R., Sengupta, S., Shen, J.C., Demidov, O.N., Saito, S., Onogi, H., Kumamoto, K., Wincovitch, S., Garfield, S.H., McMenamin, M., Nagashima, M., Grossman, S.R., Appella, E., Harris, C.C. Mol. Cell. Biol. (2005) [Pubmed]
  9. Solution structure and NMR characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ING4. Palacios, A., Garcia, P., Padr??, D., L??pez-Hern??ndez, E., Mart??n, I., Blanco, F.J. FEBS Lett. (2006) [Pubmed]
  10. The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells. Chin, M.Y., Ng, K.C., Li, G. Exp. Cell Res. (2005) [Pubmed]
  11. ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells. Sarker, K.P., Kataoka, H., Chan, A., Netherton, S.J., Pot, I., Huynh, M.A., Feng, X., Bonni, A., Riabowol, K., Bonni, S. J. Biol. Chem. (2008) [Pubmed]
  12. Exploration of novel motifs derived from mouse cDNA sequences. Kawaji, H., Schönbach, C., Matsuo, Y., Kawai, J., Okazaki, Y., Hayashizaki, Y., Matsuda, H. Genome Res. (2002) [Pubmed]
  13. Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis. Wang, Y., Wang, J., Li, G. FEBS Lett. (2006) [Pubmed]
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