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Gene Review

ING4  -  inhibitor of growth family, member 4

Homo sapiens

Synonyms: Inhibitor of growth protein 4, My036, my036, p29ING4
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Disease relevance of ING4


High impact information on ING4


Chemical compound and disease context of ING4

  • In addition to its nuclear functions, cytoplasmic ING4 interacts with liprin alpha1 to regulate cell migration and, with its known antiangiogenic function, may prevent invasion and metastasis [5].

Biological context of ING4


Anatomical context of ING4


Associations of ING4 with chemical compounds


Physical interactions of ING4

  • However, which region of ING4 could have contributed to the binding to p53 remains largely unclear [8].

Regulatory relationships of ING4


Other interactions of ING4

  • Furthermore, the interaction of ING4 to p53 was abrogated in vitro and in vivo when certain mutations or the entire deletion of the NLS domain occurred [8].
  • The potential tumor suppressor ING4 was recently shown to be a critical regulator of NF-kappaB-mediated IL-8 transcription and subsequent angiogenesis in gliomas [9].
  • These results indicate that p29ING4 and p28ING5 may be significant modulators of p53 function [10].
  • These data provide evidence for the role of ING4 in mediating the effect of low K intake on ROMK channel activity by stimulation of p38 and ERK MAPK [11].

Analytical, diagnostic and therapeutic context of ING4

  • Quantitative real-time RT-PCR analysis demonstrated decreased expression of ING4 mRNA in 76% of primary tumors as compared with that of matched normal samples [3].
  • In mice, xenografts of human glioblastoma U87MG, which has decreased expression of ING4, grow significantly faster and have higher vascular volume fractions than control tumours [4].
  • Using the ING4 wobble isoforms as an example, we demonstrated that capillary electrophoresis can precisely separate DNA fragments with a small difference in size (<3 nt) and can be used to quantify the expression ratio, which thus measures the distribution of each splicing-junction wobble isoform in tissues [12].


  1. A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer. Kim, S., Chin, K., Gray, J.W., Bishop, J.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF). Ozer, A., Wu, L.C., Bruick, R.K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas. Gunduz, M., Nagatsuka, H., Demircan, K., Gunduz, E., Cengiz, B., Ouchida, M., Tsujigiwa, H., Yamachika, E., Fukushima, K., Beder, L., Hirohata, S., Ninomiya, Y., Nishizaki, K., Shimizu, K., Nagai, N. Gene (2005) [Pubmed]
  4. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. Garkavtsev, I., Kozin, S.V., Chernova, O., Xu, L., Winkler, F., Brown, E., Barnett, G.H., Jain, R.K. Nature (2004) [Pubmed]
  5. Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1. Shen, J.C., Unoki, M., Ythier, D., Duperray, A., Varticovski, L., Kumamoto, K., Pedeux, R., Harris, C.C. Cancer Res. (2007) [Pubmed]
  6. ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells. Zhang, X., Xu, L.S., Wang, Z.Q., Wang, K.S., Li, N., Cheng, Z.H., Huang, S.Z., Wei, D.Z., Han, Z.G. FEBS Lett. (2004) [Pubmed]
  7. Solution structure and NMR characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ING4. Palacios, A., Garcia, P., Padr??, D., L??pez-Hern??ndez, E., Mart??n, I., Blanco, F.J. FEBS Lett. (2006) [Pubmed]
  8. Nuclear localization signal of ING4 plays a key role in its binding to p53. Zhang, X., Wang, K.S., Wang, Z.Q., Xu, L.S., Wang, Q.W., Chen, F., Wei, D.Z., Han, Z.G. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  9. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Brat, D.J., Bellail, A.C., Van Meir, E.G. Neuro-oncology (2005) [Pubmed]
  10. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. Shiseki, M., Nagashima, M., Pedeux, R.M., Kitahama-Shiseki, M., Miura, K., Okamura, S., Onogi, H., Higashimoto, Y., Appella, E., Yokota, J., Harris, C.C. Cancer Res. (2003) [Pubmed]
  11. Inhibitor of growth 4 (ING4) is up-regulated by a low K intake and suppresses renal outer medullary K channels (ROMK) by MAPK stimulation. Zhang, X., Lin, D.H., Jin, Y., Wang, K.S., Zhang, Y., Babilonia, E., Wang, Z., Wang, Z., Giebisch, G., Han, Z.G., Wang, W.H. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  12. Quantitative analysis of wobble splicing indicates that it is not tissue specific. Tsai, K.W., Lin, W.C. Genomics (2006) [Pubmed]
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