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MeSH Review

Vagus Nerve

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Disease relevance of Vagus Nerve


Psychiatry related information on Vagus Nerve


High impact information on Vagus Nerve


Chemical compound and disease context of Vagus Nerve


Biological context of Vagus Nerve


Anatomical context of Vagus Nerve


Associations of Vagus Nerve with chemical compounds


Gene context of Vagus Nerve

  • Direct electrical stimulation of the peripheral vagus nerve in vivo during lethal endotoxaemia in rats inhibited TNF synthesis in liver, attenuated peak serum TNF amounts, and prevented the development of shock [34].
  • Accumulation of immunoreactivity proximal to a ligature showed that mGluR were transported peripherally in the vagus nerves [35].
  • Issues considered include, the effects of systemic injection of CCK on consummatory and operant feeding, the role of the vagus nerve, the effects of CCKB receptor antagonists, and the neuroendocrine responses to exogenous CCK [36].
  • The motor neurites expressing R-cadherin have a different course within the brain than the sensory neurites expressing N-cadherin, although they form the common sensory/motor roots of the vagus nerve at the surface of the brain [37].
  • In addition, our analyses establish Nurr1 as an early marker for the dorsal motor nucleus (DMN) of the vagus nerve [38].

Analytical, diagnostic and therapeutic context of Vagus Nerve


  1. Ventricular asystole during vagus nerve stimulation for epilepsy in humans. Lanska, D.J. Neurology (2000) [Pubmed]
  2. Pharmacological aspects of anticancer drug-induced emesis with emphasis on serotonin release and vagal nerve activity. Minami, M., Endo, T., Hirafuji, M., Hamaue, N., Liu, Y., Hiroshige, T., Nemoto, M., Saito, H., Yoshioka, M. Pharmacol. Ther. (2003) [Pubmed]
  3. Effects of capsaicin applied perineurally to the vagus nerve on cardiovascular and respiratory functions in the cat. Jancsó, G., Such, G. J. Physiol. (Lond.) (1983) [Pubmed]
  4. Influence of vagotomy on changes in feline plasma catecholamine levels induced by occlusion of either the left or right coronary vessel. Williford, D.J., Zavadil, A.P., Walsh, R.A., Weise, V., Kopin, I.J., Gillis, R.A. Cardiovasc. Res. (1983) [Pubmed]
  5. The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis. van Westerloo, D.J., Giebelen, I.A., Florquin, S., Daalhuisen, J., Bruno, M.J., de Vos, A.F., Tracey, K.J., van der Poll, T. J. Infect. Dis. (2005) [Pubmed]
  6. Chronic vagus nerve stimulation improves alertness and reduces rapid eye movement sleep in patients affected by refractory epilepsy. Rizzo, P., Beelke, M., De Carli, F., Canovaro, P., Nobili, L., Robert, A., Tanganelli, P., Regesta, G., Ferrillo, F. Sleep. (2003) [Pubmed]
  7. The recognition and management of mood disorders as a comorbidity of epilepsy. Barry, J.J. Epilepsia (2003) [Pubmed]
  8. Systemic lipopolysaccharide influences rectal sensitivity in rats: role of mast cells, cytokines, and vagus nerve. Coelho, A.M., Fioramonti, J., Buéno, L. Am. J. Physiol. Gastrointest. Liver Physiol. (2000) [Pubmed]
  9. Response time, autonomic mediation, and reversibility of hyperoxic bradycardia in conscious dogs. Lodato, R.F., Jubran, A. J. Appl. Physiol. (1993) [Pubmed]
  10. Effect of peptide YY on gastric motor and secretory activity in vagally innervated and denervated corpus pouch dogs. Zai, H., Haga, N., Fujino, M.A., Itoh, Z. Regul. Pept. (1996) [Pubmed]
  11. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Wang, H., Yu, M., Ochani, M., Amella, C.A., Tanovic, M., Susarla, S., Li, J.H., Wang, H., Yang, H., Ulloa, L., Al-Abed, Y., Czura, C.J., Tracey, K.J. Nature (2003) [Pubmed]
  12. Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding. Kilpatrick, G.J., Jones, B.J., Tyers, M.B. Nature (1987) [Pubmed]
  13. Direct activation of mammalian atrial muscarinic potassium channels by GTP regulatory protein Gk. Yatani, A., Codina, J., Brown, A.M., Birnbaumer, L. Science (1987) [Pubmed]
  14. Modulation of memory processing by cholecystokinin: dependence on the vagus nerve. Flood, J.F., Smith, G.E., Morley, J.E. Science (1987) [Pubmed]
  15. Streptozotocin-induced diabetes causes metabolic changes and alterations in neurotrophin content and retrograde transport in the cervical vagus nerve. Lee, P.G., Hohman, T.C., Cai, F., Regalia, J., Helke, C.J. Exp. Neurol. (2001) [Pubmed]
  16. Mechanism of the bradycardia produced in the cat by the anticholinesterase neostigmine. Backman, S.B., Bachoo, M., Polosa, C. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  17. Choline uptake in cholinergic nodose cell bodies. Palouzier-Paulignan, B., Chamoin, M.C., Ternaux, J.P. Neuroscience (1991) [Pubmed]
  18. Actions of methoctramine, a muscarinic M2 receptor antagonist, on muscarinic and nicotinic cholinoceptors in guinea-pig airways in vivo and in vitro. Watson, N., Barnes, P.J., Maclagan, J. Br. J. Pharmacol. (1992) [Pubmed]
  19. Suppression of interictal spikes and seizures by stimulation of the vagus nerve. McLachlan, R.S. Epilepsia (1993) [Pubmed]
  20. A nonadrenergic vagal inhibitory pathway to feline airways. Diamond, L., O'Donnell, M. Science (1980) [Pubmed]
  21. Neural organization of esophageal peristalsis: role of vagus nerve. Mukhopadhyay, A.K., Weisbrodt, N.W. Gastroenterology (1975) [Pubmed]
  22. Carotid-aortic and renal baroreceptors mediate the atrial natriuretic peptide release induced by blood volume expansion. Antunes-Rodrigues, J., Machado, B.H., Andrade, H.A., Mauad, H., Ramalho, M.J., Reis, L.C., Silva-Netto, C.R., Favaretto, A.L., Gutkowska, J., McCann, S.M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  23. Vagal chemoreflex coronary vasodilation evoked by stimulating pulmonary C-fibers in dogs. Clozel, J.P., Roberts, A.M., Hoffman, J.I., Coleridge, H.M., Coleridge, J.C. Circ. Res. (1985) [Pubmed]
  24. Association of neurotensin binding sites with sensory and visceromotor components of the vagus nerve. Kessler, J.P., Beaudet, A. J. Neurosci. (1989) [Pubmed]
  25. Effect of dopamine on the esophageal smooth muscle in vivo. Rattan, S., Goyal, R.K. Gastroenterology (1976) [Pubmed]
  26. Cholinergic system modulates growth, apoptosis, and secretion of cholangiocytes from bile duct-ligated rats. LeSagE, G., Alvaro, D., Benedetti, A., Glaser, S., Marucci, L., Baiocchi, L., Eisel, W., Caligiuri, A., Phinizy, J.L., Rodgers, R., Francis, H., Alpini, G. Gastroenterology (1999) [Pubmed]
  27. Brain regulation of gastric secretion: influence of neuropeptides. Taché, Y., Vale, W., Rivier, J., Brown, M. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  28. Nervous regulation of metabolism. Niijima, A. Prog. Neurobiol. (1989) [Pubmed]
  29. Real-time and simultaneous measurement of tricuspid orifice and tricuspid anulus areas in anesthetized dogs. Tamiya, K., Higashidate, M., Kikkawa, S. Circ. Res. (1989) [Pubmed]
  30. GABA receptor control of parasympathetic outflow to heart: characterization and brainstem localization. DiMicco, J.A., Gale, K., Hamilton, B., Gillis, R.A. Science (1979) [Pubmed]
  31. Pharmacological stimulation of the cholinergic antiinflammatory pathway. Bernik, T.R., Friedman, S.G., Ochani, M., DiRaimo, R., Ulloa, L., Yang, H., Sudan, S., Czura, C.J., Ivanova, S.M., Tracey, K.J. J. Exp. Med. (2002) [Pubmed]
  32. Role of nitric oxide in parasympathetic modulation of beta-adrenergic myocardial contractility in normal dogs. Hare, J.M., Keaney, J.F., Balligand, J.L., Loscalzo, J., Smith, T.W., Colucci, W.S. J. Clin. Invest. (1995) [Pubmed]
  33. Rectal distention-induced colonic net water secretion in rats involves tachykinins, capsaicin sensory, and vagus nerves. Eutamene, H., Theodorou, V., Fioramonti, J., Bueno, L. Gastroenterology (1997) [Pubmed]
  34. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Borovikova, L.V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G.I., Watkins, L.R., Wang, H., Abumrad, N., Eaton, J.W., Tracey, K.J. Nature (2000) [Pubmed]
  35. Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons. Page, A.J., Young, R.L., Martin, C.M., Umaerus, M., O'Donnell, T.A., Cooper, N.J., Coldwell, J.R., Hulander, M., Mattsson, J.P., Lehmann, A., Blackshaw, L.A. Gastroenterology (2005) [Pubmed]
  36. Food for thought: a critique on the hypothesis that endogenous cholecystokinin acts as a physiological satiety factor. Baldwin, B.A., Parrott, R.F., Ebenezer, I.S. Prog. Neurobiol. (1998) [Pubmed]
  37. Restricted expression of N- and R-cadherin on neurites of the developing chicken CNS. Redies, C., Inuzuka, H., Takeichi, M. J. Neurosci. (1992) [Pubmed]
  38. Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem. Wallén A, A., Castro, D.S., Zetterström, R.H., Karlén, M., Olson, L., Ericson, J., Perlmann, T. Mol. Cell. Neurosci. (2001) [Pubmed]
  39. Prevention of defective axonal transport in streptozocin-diabetic rats by treatment with "Statil" (ICI 128436), an aldose reductase inhibitor. Tomlinson, D.R., Townsend, J., Fretten, P. Diabetes (1985) [Pubmed]
  40. Vagus nerve stimulation and drug reduction. Tatum, W.O., Johnson, K.D., Goff, S., Ferreira, J.A., Vale, F.L. Neurology (2001) [Pubmed]
  41. Modulation of single vagal efferent fibre discharge by gastrointestinal afferents in the rat. Davison, J.S., Grundy, D. J. Physiol. (Lond.) (1978) [Pubmed]
  42. The facial motor nucleus transcriptional program in response to peripheral nerve injury identifies Hn1 as a regeneration-associated gene. Zujovic, V., Luo, D., Baker, H.V., Lopez, M.C., Miller, K.R., Streit, W.J., Harrison, J.K. J. Neurosci. Res. (2005) [Pubmed]
  43. Effects of capsazepine against capsaicin- and proton-evoked excitation of single airway C-fibres and vagus nerve from the guinea-pig. Fox, A.J., Urban, L., Barnes, P.J., Dray, A. Neuroscience (1995) [Pubmed]
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