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Gene Review

AXL  -  AXL receptor tyrosine kinase

Homo sapiens

Synonyms: ARK, AXL oncogene, JTK11, Tyro7, Tyrosine-protein kinase receptor UFO, ...
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Disease relevance of AXL

High impact information on AXL

Biological context of AXL


Anatomical context of AXL

  • In order to demonstrate evidence for an autocrine regulation of growth in permanent hematopoietic cell lines, we measured the GAS6 expression in cell lines with strong positivity for the AXL/UFO receptor mRNA [10].

Associations of AXL with chemical compounds


Other interactions of AXL

  • Axl (or UFO/Ark) is the first member of a new class of RTK with two fibronectin type III domains and two immunoglobulin-like domains present at the extracellular domain [13].
  • MATERIALS AND METHODS: In this report, we further investigate the protein expression of the whole axl receptor tyrosine-kinase family (axl/ufo, nyk/mer and sky/rse) by immunohistochemistry and their clinicopathological associations [1].
  • A cDNA for this receptor, designated developmental tyrosine kinase (DTK), was isolated and encodes a protein with structural similarities to AXL [14].
  • Using a systematic biocomputing analysis, we identified two strong related candidate genes encoding protein tyrosine kinase receptors of the AXL subfamily [15].


  1. Clinical significance of AXL kinase family in gastric cancer. Wu, C.W., Li, A.F., Chi, C.W., Lai, C.H., Huang, C.L., Lo, S.S., Lui, W.Y., Lin, W.C. Anticancer Res. (2002) [Pubmed]
  2. Protein kinases in normal and transformed melanocytes. Quong, R.Y., Bickford, S.T., Ing, Y.L., Terman, B., Herlyn, M., Lassam, N.J. Melanoma Res. (1994) [Pubmed]
  3. Axl receptor tyrosine kinase expression in human lung cancer cell lines correlates with cellular adhesion. Wimmel, A., Glitz, D., Kraus, A., Roeder, J., Schuermann, M. Eur. J. Cancer (2001) [Pubmed]
  4. Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid. Tanaka, K., Nagayama, Y., Nakano, T., Takamura, N., Namba, H., Fukada, S., Kuma, K., Yamashita, S., Niwa, M. Endocrinology (1998) [Pubmed]
  5. Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. Varnum, B.C., Young, C., Elliott, G., Garcia, A., Bartley, T.D., Fridell, Y.W., Hunt, R.W., Trail, G., Clogston, C., Toso, R.J. Nature (1995) [Pubmed]
  6. Gas6 induces growth, beta-catenin stabilization, and T-cell factor transcriptional activation in contact-inhibited C57 mammary cells. Goruppi, S., Chiaruttini, C., Ruaro, M.E., Varnum, B., Schneider, C. Mol. Cell. Biol. (2001) [Pubmed]
  7. A PvuII-polymorphism within the AXL gene on chromosome 19q13.1. Linz, U., Schleithoff, L., Janssen, J.W., Bartram, C.R., Müller, C.R. Hum. Mol. Genet. (1993) [Pubmed]
  8. The genomic structure of the human UFO receptor. Schulz, A.S., Schleithoff, L., Faust, M., Bartram, C.R., Janssen, J.W. Oncogene (1993) [Pubmed]
  9. A novel putative tyrosine kinase receptor with oncogenic potential. Janssen, J.W., Schulz, A.S., Steenvoorden, A.C., Schmidberger, M., Strehl, S., Ambros, P.F., Bartram, C.R. Oncogene (1991) [Pubmed]
  10. Expression of the growth arrest-specific gene 6 (GAS6) in leukemia and lymphoma cell lines. Dirks, W., Rome, D., Ringel, F., Jäger, K., MacLeod, R.A., Drexler, H.G. Leuk. Res. (1999) [Pubmed]
  11. Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. Hafizi, S., Alindri, F., Karlsson, R., Dahlbäck, B. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  12. C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration. Hafizi, S., Ibraimi, F., Dahlbäck, B. FASEB J. (2005) [Pubmed]
  13. Recent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemias. Neubauer, A., Burchert, A., Maiwald, C., Gruss, H.J., Serke, S., Huhn, D., Wittig, B., Liu, E. Leuk. Lymphoma (1997) [Pubmed]
  14. Identification of a novel receptor tyrosine kinase expressed in acute myeloid leukemic blasts. Crosier, P.S., Hall, L.R., Vitas, M.R., Lewis, P.M., Crosier, K.E. Leuk. Lymphoma (1995) [Pubmed]
  15. Homozygous deletion in the coding sequence of the c-mer gene in RCS rats unravels general mechanisms of physiological cell adhesion and apoptosis. Nandrot, E., Dufour, E.M., Provost, A.C., Péquignot, M.O., Bonnel, S., Gogat, K., Marchant, D., Rouillac, C., Sépulchre de Condé, B., Bihoreau, M.T., Shaver, C., Dufier, J.L., Marsac, C., Lathrop, M., Menasche, M., Abitbol, M.M. Neurobiol. Dis. (2000) [Pubmed]
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