The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Axl  -  AXL receptor tyrosine kinase

Mus musculus

Synonyms: AI323647, Adhesion-related kinase, Ark, Tyro7, Tyrosine-protein kinase receptor UFO, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Axl


High impact information on Axl


Biological context of Axl


Anatomical context of Axl


Associations of Axl with chemical compounds

  • Spontaneous and inducible Axl cleavage was inhibited by the broad-spectrum metalloproteinase inhibitor GM6001 and by hydroxamate GW280264X, which is capable of blocking ADAM10 and ADAM17 [7].
  • Confocal microscopy and Western blot showed Ang II-dependent Gas6 and Axl expression [10].
  • In our previous study, we demonstrated that Gas6 specifically binds to phosphatidylserine (PS) and links Axl-expressing cells to the PS-coated surface [17].
  • Because oxidative stress is known to play a major role in remodeling of injured vessels, we hypothesized that H(2)O(2) might activate Axl by promoting autophosphorylation [16].
  • In intact vessels Axl was phosphorylated by H(2)O(2), and Axl phosphorylation was inhibited by warfarin treatment in balloon-injured carotids [16].
  • We demonstrate that the AP-2alpha regulated gene Axl is an essential player in GN-11 neuron migration [18].

Regulatory relationships of Axl

  • Pharmacological blockade of the phospholipase C gamma effectors, protein kinase C or calcium/calmodulin protein kinase II, had no effect on Gas6/Axl signaling to promote Rac activation or stimulate cytoskeletal reorganization and migration [19].

Other interactions of Axl


Analytical, diagnostic and therapeutic context of Axl


  1. Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases. Hafizi, S., Dahlbäck, B. Cytokine Growth Factor Rev. (2006) [Pubmed]
  2. Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival. Vajkoczy, P., Knyazev, P., Kunkel, A., Capelle, H.H., Behrndt, S., von Tengg-Kobligk, H., Kiessling, F., Eichelsbacher, U., Essig, M., Read, T.A., Erber, R., Ullrich, A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Growth arrest-specific gene 6 is involved in glomerular hypertrophy in the early stage of diabetic nephropathy. Nagai, K., Arai, H., Yanagita, M., Matsubara, T., Kanamori, H., Nakano, T., Iehara, N., Fukatsu, A., Kita, T., Doi, T. J. Biol. Chem. (2003) [Pubmed]
  4. Cloning and developmental expression analysis of the murine c-mer tyrosine kinase. Graham, D.K., Bowman, G.W., Dawson, T.L., Stanford, W.L., Earp, H.S., Snodgrass, H.R. Oncogene (1995) [Pubmed]
  5. Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Lu, Q., Gore, M., Zhang, Q., Camenisch, T., Boast, S., Casagranda, F., Lai, C., Skinner, M.K., Klein, R., Matsushima, G.K., Earp, H.S., Goff, S.P., Lemke, G. Nature (1999) [Pubmed]
  6. A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cell death control. Budagian, V., Bulanova, E., Orinska, Z., Thon, L., Mamat, U., Bellosta, P., Basilico, C., Adam, D., Paus, R., Bulfone-Paus, S. EMBO J. (2005) [Pubmed]
  7. Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum. Budagian, V., Bulanova, E., Orinska, Z., Duitman, E., Brandt, K., Ludwig, A., Hartmann, D., Lemke, G., Saftig, P., Bulfone-Paus, S. Mol. Cell. Biol. (2005) [Pubmed]
  8. Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase. Fridell, Y.W., Jin, Y., Quilliam, L.A., Burchert, A., McCloskey, P., Spizz, G., Varnum, B., Der, C., Liu, E.T. Mol. Cell. Biol. (1996) [Pubmed]
  9. Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses. Gould, W.R., Baxi, S.M., Schroeder, R., Peng, Y.W., Leadley, R.J., Peterson, J.T., Perrin, L.A. J. Thromb. Haemost. (2005) [Pubmed]
  10. Growth arrest specific protein 6/Axl signaling in human inflammatory renal diseases. Fiebeler, A., Park, J.K., Muller, D.N., Lindschau, C., Mengel, M., Merkel, S., Banas, B., Luft, F.C., Haller, H. Am. J. Kidney Dis. (2004) [Pubmed]
  11. The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a phosphatidylinositol 3-kinase-dependent pathway. Shankar, S.L., O'Guin, K., Cammer, M., McMorris, F.A., Stitt, T.N., Basch, R.S., Varnum, B., Shafit-Zagardo, B. J. Neurosci. (2003) [Pubmed]
  12. The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis. Crosier, P.S., Freeman, S.A., Orlic, D., Bodine, D.M., Crosier, K.E. Exp. Hematol. (1996) [Pubmed]
  13. The role of gamma-carboxylation in the anti-apoptotic function of gas6. Hasanbasic, I., Rajotte, I., Blostein, M. J. Thromb. Haemost. (2005) [Pubmed]
  14. Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases. Caraux, A., Lu, Q., Fernandez, N., Riou, S., Di Santo, J.P., Raulet, D.H., Lemke, G., Roth, C. Nat. Immunol. (2006) [Pubmed]
  15. Identification of Gas6 as a growth factor for human Schwann cells. Li, R., Chen, J., Hammonds, G., Phillips, H., Armanini, M., Wood, P., Bunge, R., Godowski, P.J., Sliwkowski, M.X., Mather, J.P. J. Neurosci. (1996) [Pubmed]
  16. Hydrogen peroxide activates the Gas6-Axl pathway in vascular smooth muscle cells. Konishi, A., Aizawa, T., Mohan, A., Korshunov, V.A., Berk, B.C. J. Biol. Chem. (2004) [Pubmed]
  17. Promotion of the uptake of PS liposomes and apoptotic cells by a product of growth arrest-specific gene, gas6. Ishimoto, Y., Ohashi, K., Mizuno, K., Nakano, T. J. Biochem. (2000) [Pubmed]
  18. AP-2alpha regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase. Orso, F., Jäger, R., Calogero, R.A., Schorle, H., Sismondi, P., De Bortoli, M., Taverna, D. BMC Biol. (2009) [Pubmed]
  19. Adhesion-related kinase induction of migration requires phosphatidylinositol-3-kinase and ras stimulation of rac activity in immortalized gonadotropin-releasing hormone neuronal cells. Nielsen-Preiss, S.M., Allen, M.P., Xu, M., Linseman, D.A., Pawlowski, J.E., Bouchard, R.J., Varnum, B.C., Heidenreich, K.A., Wierman, M.E. Endocrinology (2007) [Pubmed]
  20. Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis. Shankar, S.L., O'Guin, K., Kim, M., Varnum, B., Lemke, G., Brosnan, C.F., Shafit-Zagardo, B. J. Neurosci. (2006) [Pubmed]
  21. GAS6 mediates adhesion of cells expressing the receptor tyrosine kinase Axl. McCloskey, P., Fridell, Y.W., Attar, E., Villa, J., Jin, Y., Varnum, B., Liu, E.T. J. Biol. Chem. (1997) [Pubmed]
  22. Transforming activity of retroviral genomes encoding Gag-Axl fusion proteins. Zhang, Q.K., Boast, S., de los Santos, K., Begemann, M., Goff, S.P. J. Virol. (1996) [Pubmed]
  23. Identification and regulation of receptor tyrosine kinases Rse and Mer and their ligand Gas6 in testicular somatic cells. Chan, M.C., Mather, J.P., McCray, G., Lee, W.M. J. Androl. (2000) [Pubmed]
  24. Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling. Korshunov, V.A., Mohan, A.M., Georger, M.A., Berk, B.C. Circ. Res. (2006) [Pubmed]
  25. Gas6, warfarin, and kidney diseases. Yanagita, M. Clin. Exp. Nephrol. (2004) [Pubmed]
WikiGenes - Universities