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Gene Review

RCC2  -  regulator of chromosome condensation 2

Homo sapiens

Synonyms: KIAA1470, Protein RCC2, RCC1-like protein TD-60, TD-60, TD60, ...
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High impact information on RCC2

  • Colocalization of TD-60 and INCENP throughout G2 and mitosis: evidence for their possible interaction in signalling cytokinesis [1].
  • By image overlay and pixel count analysis we show that TD-60 and INCENP are distinct among known chromosome passenger proteins in extending beyond the spindle to the cortex [1].
  • Double staining experiments reveal that alpha-tubulin, TD-60 protein, and talin co-localize in the midbodies [2].
  • We introduced the rice chitinase (Cht-2; RCC2) gene into calli of Italian ryegrass (Lolium multiflorum Lam.), with a hygromycin phosphotransferase (HPT) gene as a selectable marker, by particle bombardment [3].
  • Using siRNA, we further demonstrate that the absence of TD-60 substantially suppresses overall spindle assembly, blocks cells in prometaphase, and activates the spindle assembly checkpoint [4].

Biological context of RCC2


Associations of RCC2 with chemical compounds


Other interactions of RCC2

  • We have purified and cloned the human passenger protein TD-60, and we here report that it is a member of the RCC1 family and that it binds preferentially the nucleotide-free form of the small G protein Rac1 [4].
  • The latter is consistent with a TD-60 requirement for recruitment of the passenger proteins survivin and Aurora B, and suggests that like other passenger proteins, TD-60 is involved in regulation of cell cleavage [4].
  • During metaphase, talin is located in the centromeric region of the chromosome, like the TD-60 protein and intrinsic centromere components detected by a CREST serum [2].

Analytical, diagnostic and therapeutic context of RCC2


  1. Colocalization of TD-60 and INCENP throughout G2 and mitosis: evidence for their possible interaction in signalling cytokinesis. Martineau-Thuillier, S., Andreassen, P.R., Margolis, R.L. Chromosoma (1998) [Pubmed]
  2. Talin concentrates to the midbody region during mammalian cell cytokinesis. Bellissent-Waydelich, A., Vanier, M.T., Albigès-Rizo, C., Simon-Assmann, P. J. Histochem. Cytochem. (1999) [Pubmed]
  3. Increased resistance to crown rust disease in transgenic Italian ryegrass (Lolium multiflorum Lam.) expressing the rice chitinase gene. Takahashi, W., Fujimori, M., Miura, Y., Komatsu, T., Nishizawa, Y., Hibi, T., Takamizo, T. Plant Cell Rep. (2005) [Pubmed]
  4. The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression. Mollinari, C., Reynaud, C., Martineau-Thuillier, S., Monier, S., Kieffer, S., Garin, J., Andreassen, P.R., Boulet, A., Goud, B., Kleman, J.P., Margolis, R.L. Dev. Cell (2003) [Pubmed]
  5. The quest for the holy "G" of chromosomal passengers. Burke, D.J., Stukenberg, P.T. Dev. Cell (2003) [Pubmed]
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