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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Women


Psychiatry related information on Women


High impact information on Women

  • We developed strategies that entailed no screening for low-risk women, usual care for intermediate-risk women, and universal screening with lower thresholds -- plasma glucose values of 130 mg per deciliter (7.2 mmol per liter) or 128 mg per deciliter (7.1 mmol per liter) -- for high-risk women [7].
  • In a randomized controlled trial, we studied the effect of selective intrapartum prophylaxis with ampicillin in 160 such high-risk women [8].
  • RESULTS.--Among 394 subjects from six trials, the RR of PIH among women who took aspirin was 0.35 (95% confidence interval [CI], 0.22 to 0.55) and the number needed to be treated was 4.4, meaning that between four and five high-risk women would need to be treated with aspirin to prevent one case of PIH [9].
  • Italian randomized trial among women with hysterectomy: tamoxifen and hormone-dependent breast cancer in high-risk women [10].
  • Our results failed to support the hypothesis that high-risk women (those with a family history of breast cancer) have relatively lower estriol proportions, and we concluded that whatever family history contributes to breast cancer risk, that risk is not likely to be transmitted by the estrogen profile [11].

Chemical compound and disease context of Women

  • RESULTS: Total cholesterol and triglycerides levels were similar in the healthy and the overweight women groups (6.49+/-1.25 vs 6.52+/-1.18 mmol/l; p>0.05 and 1.21+/-0.71 vs 1.41+/-0.98 mmol/l; p>0.05, respectively) [12].

Biological context of Women


Anatomical context of Women

  • Our findings suggest that defects in the regulation of glucose clearance, glucose production, and plasma FFA concentrations, together with defects in pancreatic beta-cell function, precede the development of type 2 diabetes in these high-risk women [18].
  • We report here the baseline findings from a study designed to assess the utility of ductal lavage in this setting.METHODS: Tamoxifen-eligible, high-risk women underwent ductal lavage; epithelial cell number (ECN) and morphology were assessed on Papanicolaou-stained slides [19].
  • These results suggest a dysregulation of hormonal response in the normal breast epithelium of high-risk women, with lack of regulation of ER by estradiol, increased estrogen responsiveness as reflected by PgR expression, and a dissociation of ER expression and proliferative response [20].

Associations of Women with chemical compounds


Gene context of Women


Analytical, diagnostic and therapeutic context of Women


  1. Alteration of endocrine parameters in premenopausal women with breast cancer during long-term adjuvant therapy with tamoxifen as the single agent. Jordan, V.C., Fritz, N.F., Langan-Fahey, S., Thompson, M., Tormey, D.C. J. Natl. Cancer Inst. (1991) [Pubmed]
  2. Tamoxifen therapy for breast cancer and endometrial cancer risk. Bernstein, L., Deapen, D., Cerhan, J.R., Schwartz, S.M., Liff, J., McGann-Maloney, E., Perlman, J.A., Ford, L. J. Natl. Cancer Inst. (1999) [Pubmed]
  3. Offspring gender ratio and the rate of recurrent spontaneous miscarriages in jewish women at high risk for breast/ovarian cancer. Gal, I., Sadetzki, S., Gershoni-Baruch, R., Oberman, B., Carp, H., Papa, M.Z., Diestelman-Menachem, T., Eisenberg-Barzilai, S., Friedman, E. Am. J. Hum. Genet. (2004) [Pubmed]
  4. Phosphatidylserine-dependent antiprothrombin antibodies are not useful markers for high-risk women with recurrent miscarriages. Sugiura-Ogasawara, M., Atsumi, T., Ozaki, Y., Koike, T., Suzumori, K. Fertil. Steril. (2004) [Pubmed]
  5. Notification of a family history of breast cancer: issues of privacy and confidentiality. Winter, P.R., Wiesner, G.L., Finnegan, J., Bartels, D., LeRoy, B., Chen, P.L., Sellers, T.A. Am. J. Med. Genet. (1996) [Pubmed]
  6. The future of women of minority race/ethnicity in breast cancer chemoprevention therapy. Cyrus-David, M.S. Ethnicity & disease. (2006) [Pubmed]
  7. Selective screening for gestational diabetes mellitus. Toronto Trihospital Gestational Diabetes Project Investigators. Naylor, C.D., Sermer, M., Chen, E., Farine, D. N. Engl. J. Med. (1997) [Pubmed]
  8. Prevention of early-onset neonatal group B streptococcal disease with selective intrapartum chemoprophylaxis. Boyer, K.M., Gotoff, S.P. N. Engl. J. Med. (1986) [Pubmed]
  9. A meta-analysis of low-dose aspirin for the prevention of pregnancy-induced hypertensive disease. Imperiale, T.F., Petrulis, A.S. JAMA (1991) [Pubmed]
  10. Italian randomized trial among women with hysterectomy: tamoxifen and hormone-dependent breast cancer in high-risk women. Veronesi, U., Maisonneuve, P., Rotmensz, N., Costa, A., Sacchini, V., Travaglini, R., D'Aiuto, G., Lovison, F., Gucciardo, G., Muraca, M.G., Pizzichetta, M.A., Conforti, S., Decensi, A., Robertson, C., Boyle, P. J. Natl. Cancer Inst. (2003) [Pubmed]
  11. Estrogen profiles in young women: effect of maternal history of breast cancer. Morgan, R.W., Vakil, D.V., Brown, J.B., Elinson, L. J. Natl. Cancer Inst. (1978) [Pubmed]
  12. Impact of obesity on lipid profiles in middle-aged women. Maksvytis, A., Stakisaitis, D. Medicina (Kaunas, Lithuania) (2004) [Pubmed]
  13. Dopamine supersensitivity and hormonal status in puerperal psychosis. Meakin, C.J., Brockington, I.F., Lynch, S., Jones, S.R. The British journal of psychiatry : the journal of mental science. (1995) [Pubmed]
  14. Missense mutations in the BRCT domain of BRCA-1 from high-risk women frequently perturb strongly hydrophobic amino acids conserved among mammals. Figge, M.A., Blankenship, L. Cancer Epidemiol. Biomarkers Prev. (2004) [Pubmed]
  15. Prevalence of aneuploidy, overexpressed ER, and overexpressed EGFR in random breast aspirates of women at high and low risk for breast cancer. Fabian, C.J., Zalles, C., Kamel, S., Kimler, B.F., McKittrick, R., Tranin, A.S., Zeiger, S., Moore, W.P., Hassanein, R.S., Simon, C. Breast Cancer Res. Treat. (1994) [Pubmed]
  16. Association of two angiotensinogen gene polymorphisms, M235T and G(-6)A, with chronic heart failure. Goldbergova, M., Spinarova, L., Spinar, J., Toman, J., Vasku, A., Vacha, J. International journal of cardiology. (2003) [Pubmed]
  17. Breast cytology and biomarkers obtained by random fine needle aspiration: use in risk assessment and early chemoprevention trials. Fabian, C.J., Zalles, C., Kamel, S., Zeiger, S., Simon, C., Kimler, B.F. J. Cell. Biochem. Suppl. (1997) [Pubmed]
  18. Multiple metabolic defects during late pregnancy in women at high risk for type 2 diabetes. Xiang, A.H., Peters, R.K., Trigo, E., Kjos, S.L., Lee, W.P., Buchanan, T.A. Diabetes (1999) [Pubmed]
  19. Endocrine biomarkers in ductal lavage samples from women at high risk for breast cancer. Bhandare, D., Nayar, R., Bryk, M., Hou, N., Cohn, R., Golewale, N., Parker, N.P., Chatterton, R.T., Rademaker, A., Khan, S.A. Cancer Epidemiol. Biomarkers Prev. (2005) [Pubmed]
  20. The normal breast epithelium of women with breast cancer displays an aberrant response to estradiol. Khan, S.A., Sachdeva, A., Naim, S., Meguid, M.M., Marx, W., Simon, H., Halverson, J.D., Numann, P.J. Cancer Epidemiol. Biomarkers Prev. (1999) [Pubmed]
  21. High-risk lesions in high-risk women: a high-risk formalin-based biology! Adem, C., Jenkins, R.B., Capron, F., Stoppa-Lyonnet, D. J. Clin. Oncol. (2004) [Pubmed]
  22. Effect of long-term therapy with ramipril in high-risk women. Lonn, E., Roccaforte, R., Yi, Q., Dagenais, G., Sleight, P., Bosch, J., Suhan, P., Micks, M., Probstfield, J., Bernstein, V., Yusuf, S. J. Am. Coll. Cardiol. (2002) [Pubmed]
  23. Effect of tamoxifen on mammographic density. Chow, C.K., Venzon, D., Jones, E.C., Premkumar, A., O'Shaughnessy, J., Zujewski, J. Cancer Epidemiol. Biomarkers Prev. (2000) [Pubmed]
  24. Effect of raloxifene on insulin-like growth factor-I, insulin-like growth factor binding protein-3, and leptin in premenopausal women at high risk for developing breast cancer. Eng-Wong, J., Hursting, S.D., Venzon, D., Perkins, S.N., Zujewski, J.A. Cancer Epidemiol. Biomarkers Prev. (2003) [Pubmed]
  25. Periconceptional vitamin profiles are not suitable for identifying women at risk for neural tube defects. Mooij, P.N., Steegers-Theunissen, R.P., Thomas, C.M., Doesburg, W.H., Eskes, T.K. J. Nutr. (1993) [Pubmed]
  26. Patterns of reduced nipple aspirate fluid production and ductal lavage cellularity in women at high risk for breast cancer. Higgins, S.A., Matloff, E.T., Rimm, D.L., Dziura, J., Haffty, B.G., King, B.L. Breast Cancer Res. (2005) [Pubmed]
  27. Use of CA-125 and ultrasound in high-risk women. Laframboise, S., Nedelcu, R., Murphy, J., Cole, D.E., Rosen, B. Int. J. Gynecol. Cancer (2002) [Pubmed]
  28. TNF-receptor levels in preeclampsia--results of a longitudinal study in high-risk women. Schipper, E.J., Bolte, A.C., Schalkwijk, C.G., Van Geijn, H.P., Dekker, G.A. J. Matern. Fetal. Neonatal. Med. (2005) [Pubmed]
  29. Hostility and physiological risk in the National Heart, Lung, and Blood Institute Family Heart Study. Knox, S.S., Weidner, G., Adelman, A., Stoney, C.M., Ellison, R.C. Arch. Intern. Med. (2004) [Pubmed]
  30. Time trends in systemic adjuvant treatment for node-negative breast cancer. Hébert-Croteau, N., Brisson, J., Latreille, J., Gariépy, G., Blanchette, C., Deschênes, L. J. Clin. Oncol. (1999) [Pubmed]
  31. Management of risk of breast carcinoma in postmenopausal women. Biglia, N., Defabiani, E., Ponzone, R., Mariani, L., Marenco, D., Sismondi, P. Endocr. Relat. Cancer (2004) [Pubmed]
  32. Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone. Zhang, F., Fan, P.W., Liu, X., Shen, L., van Breeman, R.B., Bolton, J.L. Chem. Res. Toxicol. (2000) [Pubmed]
  33. Chemoprevention of breast cancer. Powles, T.J., Hardy, J.R., Ashley, S.E., Cosgrove, D., Davey, J.B., Dowsett, M., McKinna, A., Nash, A.G., Rundle, S.K., Sinnett, H.D. Breast Cancer Res. Treat. (1989) [Pubmed]
  34. Identification of severe or extensive coronary artery disease in women by adenosine technetium-99m sestamibi SPECT. Amanullah, A.M., Berman, D.S., Hachamovitch, R., Kiat, H., Kang, X., Friedman, J.D. Am. J. Cardiol. (1997) [Pubmed]
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