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Gene Review:

Parva - parvin, alpha

Rattus norvegicus

Synonyms: Actopaxin, Actp, Alpha-parvin

Curtis, M. et al., Nikolopoulos, S.N. et al., Choi, M.H. et al., Nandan, D. et al., LaLonde, D.P. et al., et al.

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Disease relevance of Parva

Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites [1].
When cercariae were kept in the same bath as the freshwater fish, Pseudorasbora parva, which were free from trematode infections, parasites encysted only in the gills of fishes at day 4 postinfection (PI) [2].
Pseudorasbora parva were collected at an endemic river of clonorchiasis and were used for irradiation of the fluke in three schemes [3].

High impact information on Parva

Together, these results suggest an important role for actopaxin in integrin-dependent remodeling of the actin cytoskeleton during cell motility and cell adhesion [4].
In addition, ectopic expression of the PBS mutant and/or the COOH terminus of actopaxin in HeLa cells resulted in substantial reduction in adhesion to collagen [4].
The focal adhesion protein actopaxin contributes to integrin-actin associations and is involved in cell adhesion, spreading, and motility [5].
Taken together, these results suggest a role for cyclin B1/cdc2-dependent phosphorylation of actopaxin in regulating actin cytoskeleton reorganization during cell division [6].
Finally, as cells progress from mitosis to G(1) there is an adhesion-independent dephosphorylation of actopaxin, suggesting that actopaxin dephosphorylation precedes cell spreading and the reformation of focal adhesions [6].

Biological context of Parva

In this study, we investigate the mitotic phosphorylation of the recently described paxillin and actin-binding focal-adhesion protein actopaxin [Nikolopoulos and Turner (2000) J. Cell Biol. 151, 1435-1448] [6].

Anatomical context of Parva

Characterisation of the gene encoding a candidate vaccine antigen of Theileria parva sporozoites [7].
A different monoclonal antibody, SPA-820, which also recognises members of the hsp 70 kDa family, bound to proteins isolated from Theileria parva Muguga transformed lymphoblastoid cell lines (TpM) [8].

Analytical, diagnostic and therapeutic context of Parva

Western blotting identifies actopaxin as a widely expressed protein [4].

References

Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites. Bishop, R., Nene, V., Staeyert, J., Rowlands, J., Nyanjui, J., Osaso, J., Morzaria, S., Musoke, A. Vaccine (2003) [Pubmed]
Morphological observations of Echinochasmus japonicus cercariae and the in vitro maintenance of its life cycle from cercariae to adults. Choi, M.H., Kim, S.H., Chung, J.H., Jang, H.J., Eom, J.H., Chung, B.S., Sohn, W.M., Chai, J.Y., Hong, S.T. J. Parasitol. (2006) [Pubmed]
The effects of gamma irradiation on the survival and development of Clonorchis sinensis metacercariae. Lee, S.H., Park, Y.H., Sohn, W.M., Hong, S.T., Chai, J.Y. Kisaengchunghak Chapchi (1989) [Pubmed]
Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion. Nikolopoulos, S.N., Turner, C.E. J. Cell Biol. (2000) [Pubmed]
Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin. LaLonde, D.P., Brown, M.C., Bouverat, B.P., Turner, C.E. J. Biol. Chem. (2005) [Pubmed]
Actopaxin is phosphorylated during mitosis and is a substrate for cyclin B1/cdc2 kinase. Curtis, M., Nikolopoulos, S.N., Turner, C.E. Biochem. J. (2002) [Pubmed]
Characterisation of the gene encoding a candidate vaccine antigen of Theileria parva sporozoites. Nene, V., Iams, K.P., Gobright, E., Musoke, A.J. Mol. Biochem. Parasitol. (1992) [Pubmed]
A rapid, single-step purification method for immunogenic members of the hsp 70 family: validation and application. Nandan, D., Daubenberger, C., Mpimbaza, G., Pearson, T.W. J. Immunol. Methods (1994) [Pubmed]

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