The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PARVA  -  parvin, alpha

Homo sapiens

Synonyms: Actopaxin, Alpha-parvin, CH-ILKBP, Calponin-like integrin-linked kinase-binding protein, FLJ10793, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PARVA


Psychiatry related information on PARVA

  • Scientists agree that Aristotle in his Parva Naturalia was the first to report a visual illusion known as the motion aftereffect (MAE) [6].
  • Delta-9-tetrahydrocannabinol differentially suppresses emesis versus enhanced locomotor activity produced by chemically diverse dopamine D2/D3 receptor agonists in the least shrew (Cryptotis parva) [7].

High impact information on PARVA


Chemical compound and disease context of PARVA


Biological context of PARVA

  • The human alpha-parvin gene (PARVA), extending over 160 kb, is located on chromosome 11 [15].
  • Furthermore, they demonstrate that alpha- and beta-parvins play distinct roles in mammalian cells and suggest that the formation of the ILK-alpha-parvin complex is crucial for protection of cells from apoptosis [16].
  • Here we demonstrate, using several different approaches, that inhibiting ILK kinase activity, or expression, results in the inhibition of cell attachment, cell migration, F-actin organization, and the specific cytoskeletal localization of CH-ILKBP and paxillin in human cells [17].
  • The activating phosphorylation of protein kinase B (PKB/Akt), a key regulator of apoptosis, is impaired in the absence of CH-ILKBP [9].
  • Furthermore, the CH2 domain alone is sufficient for FA targeting, and a point mutation that inhibits the ILK-binding impaired the FA localization of CH-ILKBP [18].

Anatomical context of PARVA

  • In this study, we investigated the role of ILK, and its binding partners PINCH, alpha-parvin, and Mig-2 in matrix-induced hepatocyte differentiation [19].
  • We show here that ILK forms a complex with PINCH and CH-ILKBP in primary mesangial cells, which are co-clustered at fibrillar adhesions, sites that are involved in fibronectin matrix deposition [20].
  • The GFP-tagged alpha-parvin co-localizes with actin filaments at membrane ruffles, focal contacts and tensin-rich fibers in the central area of fibroblasts [21].
  • Theileria parva infection induces autocrine growth of bovine lymphocytes [22].
  • The clones were derived from peripheral blood mononuclear cells of an animal immunized with T. parva (Muguga stock), after five stimulations in vitro with an autologous parasitized cell line [23].

Associations of PARVA with chemical compounds


Regulatory relationships of PARVA


Other interactions of PARVA


Analytical, diagnostic and therapeutic context of PARVA


  1. Immunity in theileriosis. Irvin, A.D. Parasitol. Today (Regul. Ed.) (1985) [Pubmed]
  2. Artificial feeding of ixodid ticks. Waladde, S.M., Young, A.S., Morzaria, S.P. Parasitol. Today (Regul. Ed.) (1996) [Pubmed]
  3. Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A. Darmani, N.A. Neuropsychopharmacology (2001) [Pubmed]
  4. Molecular genetic variation in Emmonsia crescens and Emmonsia parva, etiologic agents of adiaspiromycosis, and their phylogenetic relationship to Blastomyces dermatitidis (Ajellomyces dermatitidis) and other systemic fungal pathogens. Peterson, S.W., Sigler, L. J. Clin. Microbiol. (1998) [Pubmed]
  5. Reclassification of Leptospira parva Hovind-Hougen et al. 1982 as Turneriella parva gen. nov., comb. nov. Levett, P.N., Morey, R.E., Galloway, R., Steigerwalt, A.G., Ellis, W.A. Int. J. Syst. Evol. Microbiol. (2005) [Pubmed]
  6. On the ancient history of the direction of the motion aftereffect. Verstraten, F.A. Perception. (1996) [Pubmed]
  7. Delta-9-tetrahydrocannabinol differentially suppresses emesis versus enhanced locomotor activity produced by chemically diverse dopamine D2/D3 receptor agonists in the least shrew (Cryptotis parva). Darmani, N.A., Crim, J.L. Pharmacol. Biochem. Behav. (2005) [Pubmed]
  8. Antibodies against major histocompatibility complex class II antigens directly inhibit the growth of T cells infected with Theileria parva without affecting their state of activation. Eichhorn, M., Prospero, T.D., Heussler, V.T., Dobbelaere, D.A. J. Exp. Med. (1993) [Pubmed]
  9. CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt. Fukuda, T., Guo, L., Shi, X., Wu, C. J. Cell Biol. (2003) [Pubmed]
  10. 1,3-dinitrobenzene toxicity in the least shrew, Cryptotis parva. Mock, O.B., Casteel, S.W., Darmani, N.A., Shaddy, J.H., Besch-Williford, C., Towns, L.C. Environ. Toxicol. Chem. (2005) [Pubmed]
  11. Delta-9-tetrahydrocannabinol differentially suppresses cisplatin-induced emesis and indices of motor function via cannabinoid CB(1) receptors in the least shrew. Darmani, N.A. Pharmacol. Biochem. Behav. (2001) [Pubmed]
  12. The role of D2 and D3 dopamine receptors in the mediation of emesis in Cryptotis parva (the least shrew). Darmani, N.A., Zhao, W., Ahmad, B. Journal of neural transmission (Vienna, Austria : 1996) (1999) [Pubmed]
  13. Serotonin 5-HT3 receptor antagonists prevent cisplatin-induced emesis in Cryptotis parva: a new experimental model of emesis. Darmani, N.A. Journal of neural transmission (Vienna, Austria : 1996) (1998) [Pubmed]
  14. Stimulatory effect of procaine on the growth of several microalgae and cyanobacteria. Suzuki, T., Ezure, T., Yamaguchi, T., Domen, H., Ishida, M., Schmidt, W. J. Pharm. Pharmacol. (2000) [Pubmed]
  15. Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans. Korenbaum, E., Olski, T.M., Noegel, A.A. Gene (2001) [Pubmed]
  16. Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. Zhang, Y., Chen, K., Tu, Y., Wu, C. J. Biol. Chem. (2004) [Pubmed]
  17. Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN. Attwell, S., Mills, J., Troussard, A., Wu, C., Dedhar, S. Mol. Biol. Cell (2003) [Pubmed]
  18. A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading. Tu, Y., Huang, Y., Zhang, Y., Hua, Y., Wu, C. J. Cell Biol. (2001) [Pubmed]
  19. Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation. Gkretsi, V., Bowen, W.C., Yang, Y., Wu, C., Michalopoulos, G.K. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  20. Regulation of fibronectin matrix deposition and cell proliferation by the PINCH-ILK-CH-ILKBP complex. Guo, L., Wu, C. FASEB J. (2002) [Pubmed]
  21. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily. Olski, T.M., Noegel, A.A., Korenbaum, E. J. Cell. Sci. (2001) [Pubmed]
  22. Theileria parva infection induces autocrine growth of bovine lymphocytes. Dobbelaere, D.A., Coquerelle, T.M., Roditi, I.J., Eichhorn, M., Williams, R.O. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  23. Bovine cytotoxic T-cell clones specific for cells infected with the protozoan parasite Theileria parva: parasite strain specificity and class I major histocompatibility complex restriction. Goddeeris, B.M., Morrison, W.I., Teale, A.J., Bensaid, A., Baldwin, C.L. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  24. Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. Zhang, Y., Chen, K., Tu, Y., Velyvis, A., Yang, Y., Qin, J., Wu, C. J. Cell. Sci. (2002) [Pubmed]
  25. Jun NH2-terminal kinase is constitutively activated in T cells transformed by the intracellular parasite Theileria parva. Galley, Y., Hagens, G., Glaser, I., Davis, W., Eichhorn, M., Dobbelaere, D. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  26. IL-2 can enhance the cyclosporin A-mediated inhibition of Theileria parva-infected T cell proliferation. Eichhorn, M., Magnuson, N.S., Reeves, R., Williams, R.O., Dobbelaere, D.A. J. Immunol. (1990) [Pubmed]
  27. Group I introns within the nuclear-encoded small-subunit rRNA gene of three green algae. Wilcox, L.W., Lewis, L.A., Fuerst, P.A., Floyd, G.L. Mol. Biol. Evol. (1992) [Pubmed]
  28. Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew. Darmani, N.A., McClanahan, B.A., Trinh, C., Petrosino, S., Valenti, M., Di Marzo, V. Neuropharmacology (2005) [Pubmed]
  29. Characterisation of bovine transferrin receptor on normal activated and Theileria parva-transformed lymphocytes by a new monoclonal antibody. Naessens, J., Grab, D.J., Fritsch, G. Vet. Immunol. Immunopathol. (1996) [Pubmed]
  30. PINCH-1 is an obligate partner of integrin-linked kinase (ILK) functioning in cell shape modulation, motility, and survival. Fukuda, T., Chen, K., Shi, X., Wu, C. J. Biol. Chem. (2003) [Pubmed]
  31. The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly. Wang, X., Fukuda, K., Byeon, I.J., Velyvis, A., Wu, C., Gronenborn, A., Qin, J. J. Biol. Chem. (2008) [Pubmed]
  32. Cortical organization in shrews: evidence from five species. Catania, K.C., Lyon, D.C., Mock, O.B., Kaas, J.H. J. Comp. Neurol. (1999) [Pubmed]
  33. Use of freeze-substitution and molecular distillation drying in the preparation of Dunaliella parva for ion localization studies by X-ray microanalysis. Hajibagheri, M.A., Flowers, T.J. Microsc. Res. Tech. (1993) [Pubmed]
  34. Low-dose oral administration of human interferon alpha can control the development of Theileria parva infection in cattle. Young, A.S., Maritim, A.C., Kariuki, D.P., Stagg, D.A., Wafula, J.M., Mutugi, J.J., Cummins, J.M., Richards, A.B., Burns, C. Parasitology (1990) [Pubmed]
  35. Infection of mammalian cells with Theileria species. Stagg, D.A., Young, A.S., Leitch, B.L., Grootenhuis, J.G., Dolan, T.T. Parasitology (1983) [Pubmed]
  36. Sectio parva for fetal preservation. Bruner, J.P., Wheeler, T.C., Bliton, M.J. Fetal. Diagn. Ther. (1999) [Pubmed]
WikiGenes - Universities