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Gene Review

P2ry4  -  pyrimidinergic receptor P2Y, G-protein...

Rattus norvegicus

Synonyms: P2Y purinoceptor 4, P2Y4, P2y4
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High impact information on P2ry4

  • Immunohistochemical staining was used to detect the corresponding P2Y proteins (P2Y1, P2Y2, and P2Y4) and their cellular localization [1].
  • Exogenously added NGF then augmented hypoglycemic neuronal death by about 60%, increasing the percentage of Höechst-positive nuclei (from approximately 62 to 95%), reducing lactate dehydrogenase (LDH) release (from about 50 to 14%) and significantly overstimulating the hypoglycemia-induced expression of P2X7 and P2Y4 [2].
  • The triphosphate was more potent than UTP in inducing a dilatory P2Y4 response (pEC(50) = 6.1 +/- 0.2), while the diphosphate was inactive as either an agonist or antagonist in a P2Y6 receptor-mediated contractile response [3].
  • CONCLUSIONS: Stimulation of glomerular mesangial cells via P2Y2 and/or P2Y4 and via P2X7 receptors can induce proliferation and apoptotic cell death, respectively [4].
  • A full-length sequence obtained for one novel clone (R5) contained an intronless open reading frame that encoded a polypeptide of 361 amino acids, sharing 84% sequence identity with the human P2Y4 receptor [5].

Biological context of P2ry4


Anatomical context of P2ry4


Associations of P2ry4 with chemical compounds

  • 2-Methylthio-ATP (0.1-10 microM), an agonist that can act at P2Y1 receptors, did not contract arteries or veins, whereas UTP, an agonist at rat P2Y2/P2Y4 receptors, contracted veins (EC(50) = 15 microM) and arteries (EC(50) = 24 microM) [12].
  • It occurs when uridine 5'-triphosphate is bath applied at low micromolar concentrations and is prevented by Reactive Blue 2, suggesting that it is mediated by P2Y4 receptors [13].
  • Application of alpha,beta-methylene ATP (alphabeta-meATP) and UTP, putative P2X and P2Y2 or P2Y4 purinoceptor agonists, induced transient and oscillatory inward currents, respectively [14].
  • Furthermore, the pharmacological profile of the native UTP/UDP receptor differs from that of the known P2Y2, P2Y4 and P2Y6 recombinant receptors for pyrimidine nucleotides [15].

Other interactions of P2ry4

  • The wide distribution of the uridine nucleotide-activated P2Y2, P2Y4 and P2Y6 receptors suggests a role for UTP as an important extracellular signalling molecule [16].

Analytical, diagnostic and therapeutic context of P2ry4


  1. Expression of P2Y1, P2Y2, P2Y4, and P2Y6 receptor subtypes in the rat retina. Fries, J.E., Wheeler-Schilling, T.H., Guenther, E., Kohler, K. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  2. Extracellular ATP and nerve growth factor intensify hypoglycemia-induced cell death in primary neurons: role of P2 and NGFRp75 receptors. Cavaliere, F., Sancesario, G., Bernardi, G., Volonté, C. J. Neurochem. (2002) [Pubmed]
  3. Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors. Kim, H.S., Ravi, R.G., Marquez, V.E., Maddileti, S., Wihlborg, A.K., Erlinge, D., Malmsjö, M., Boyer, J.L., Harden, T.K., Jacobson, K.A. J. Med. Chem. (2002) [Pubmed]
  4. Induction of proliferation and apoptotic cell death via P2Y and P2X receptors, respectively, in rat glomerular mesangial cells. Harada, H., Chan, C.M., Loesch, A., Unwin, R., Burnstock, G. Kidney Int. (2000) [Pubmed]
  5. Molecular cloning and characterization of the rat P2Y4 receptor. Webb, T.E., Henderson, D.J., Roberts, J.A., Barnard, E.A. J. Neurochem. (1998) [Pubmed]
  6. Molecular cloning and characterization of the mouse P2Y4 nucleotide receptor. Suarez-Huerta, N., Pouillon, V., Boeynaems, J., Robaye, B. Eur. J. Pharmacol. (2001) [Pubmed]
  7. P2X and P2Y purinoceptor expression in pancreas from streptozotocin-diabetic rats. Coutinho-Silva, R., Parsons, M., Robson, T., Lincoln, J., Burnstock, G. Mol. Cell. Endocrinol. (2003) [Pubmed]
  8. Purinergic signalling to rat ovarian smooth muscle: changes in P2X receptor expression during pregnancy. Katugampola, H., Burnstock, G. Cells Tissues Organs (Print) (2004) [Pubmed]
  9. The pattern of distribution of selected ATP-sensitive P2 receptor subtypes in normal rat kidney: an immunohistological study. Turner, C.M., Vonend, O., Chan, C., Burnstock, G., Unwin, R.J. Cells Tissues Organs (Print) (2003) [Pubmed]
  10. Localisation of P2Y1 and P2Y4 receptors in dorsal root, nodose and trigeminal ganglia of the rat. Ruan, H.Z., Burnstock, G. Histochem. Cell Biol. (2003) [Pubmed]
  11. P2Y2 and P2Y4 receptors regulate pancreatic Ca(2+)-activated K+ channels differently. Hede, S.E., Amstrup, J., Klaerke, D.A., Novak, I. Pflugers Arch. (2005) [Pubmed]
  12. Differential localization of P2 receptor subtypes in mesenteric arteries and veins of normotensive and hypertensive rats. Galligan, J.J., Hess, M.C., Miller, S.B., Fink, G.D. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  13. Long-term potentiation of glutamatergic synaptic transmission induced by activation of presynaptic P2Y receptors in the rat medial habenula nucleus. Price, G.D., Robertson, S.J., Edwards, F.A. Eur. J. Neurosci. (2003) [Pubmed]
  14. Effects of UTP on membrane current and potential in rat aortic myocytes. Muraki, K., Imaizumi, Y., Watanabe, M. Eur. J. Pharmacol. (1998) [Pubmed]
  15. Regulation of vascular tone by UTP and UDP in isolated rat intrapulmonary arteries. Rubino, A., Ziabary, L., Burnstock, G. Eur. J. Pharmacol. (1999) [Pubmed]
  16. Quantitation of extracellular UTP using a sensitive enzymatic assay. Lazarowski, E.R., Harden, T.K. Br. J. Pharmacol. (1999) [Pubmed]
  17. P2Y purinoceptor activation mobilizes intracellular Ca2+ and induces a membrane current in rat intracardiac neurones. Liu, D.M., Katnik, C., Stafford, M., Adams, D.J. J. Physiol. (Lond.) (2000) [Pubmed]
  18. ATP and UTP at low concentrations strongly inhibit bone formation by osteoblasts: a novel role for the P2Y2 receptor in bone remodeling. Hoebertz, A., Mahendran, S., Burnstock, G., Arnett, T.R. J. Cell. Biochem. (2002) [Pubmed]
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