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Gene Review

UCP1  -  uncoupling protein 1 (mitochondrial,...

Macaca mulatta

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Disease relevance of UCP1


High impact information on UCP1

  • With the discovery of L-755,507, a potent and selective partial agonist for both human and rhesus beta3 receptors, we now demonstrate that acute exposure of rhesus monkeys to a beta3 agonist elicits lipolysis and metabolic rate elevation, and that chronic exposure increases uncoupling protein 1 expression in rhesus brown adipose tissue [1].
  • Recent studies have shown that a mitochondrial uncoupling protein (UCP2), which uncouples mitochondrial oxidation from phosphorylation, is expressed in the rodent brain by neurons that are known to regulate autonomic, metabolic, and endocrine processes [2].
  • In rats fed diets low in protein, there appears to be a dissociation between the concentration of uncoupling protein and the number of nucleotide binding sites as given by the [3H]GDP binding assay [3].
  • Rhesus monkey BAT mitochondria (BATM) possess an uncoupling protein that is characteristic of BAT as evidenced by the binding of [3H]GDP, the inhibition by GDP of the high Cl- permeability or rapid alpha-glycerol-3-phosphate oxidation [4].

Analytical, diagnostic and therapeutic context of UCP1


  1. A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys. Fisher, M.H., Amend, A.M., Bach, T.J., Barker, J.M., Brady, E.J., Candelore, M.R., Carroll, D., Cascieri, M.A., Chiu, S.H., Deng, L., Forrest, M.J., Hegarty-Friscino, B., Guan, X.M., Hom, G.J., Hutchins, J.E., Kelly, L.J., Mathvink, R.J., Metzger, J.M., Miller, R.R., Ok, H.O., Parmee, E.R., Saperstein, R., Strader, C.D., Stearns, R.A., MacIntyre, D.E. J. Clin. Invest. (1998) [Pubmed]
  2. Mitochondrial uncoupling protein 2 (UCP2) in the nonhuman primate brain and pituitary. Diano, S., Urbanski, H.F., Horvath, B., Bechmann, I., Kagiya, A., Nemeth, G., Naftolin, F., Warden, C.H., Horvath, T.L. Endocrinology (2000) [Pubmed]
  3. Immunochemical detection and quantitation of brown adipose tissue uncoupling protein. Henningfield, M.F., Swick, R.W. Biochem. Cell Biol. (1987) [Pubmed]
  4. Brown adipose tissue from fetal rhesus monkey (Macaca mulatta): morphological and biochemical aspects. Strieleman, P.J., Gribskov, C.L., Kemnitz, J.W., Schalinske, K.L., Claude, P., Parada, I., Shrago, E., Swick, R.W. Comp. Biochem. Physiol., B (1985) [Pubmed]
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