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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Densitometry


Psychiatry related information on Densitometry


High impact information on Densitometry

  • Technetium bone scans and bone densitometry determinations proved insensitive for detection of skeletal changes [8].
  • Thyroid functions in patients receiving long-term levothyroxine treatment should be closely monitored and bone densitometry should be performed in patients at risk for osteoporosis [9].
  • When a novel inhibitor of the glycoprotein IIb/IIIa receptor (SDZ GPI 562) was administered immediately before MCA occlusion, platelet accumulation was reduced 48%, and fibrin accumulation was reduced by 47% by immunoblot densitometry [10].
  • Immunoblotting and densitometry revealed a decrease in AQP2 levels to 27+/-3.4% of control levels (n=11, P<0.001) in inner medulla, and 34+/-15% of controls (n=5, P<0.05) in cortex [11].
  • Using a 1.3-kb rat cardiac DHP receptor probe, and Northern analysis quantified by laser densitometry, we found that norepinephrine exposure produced a 2.2-fold increase in DHP receptor mRNA levels at 2 h followed by a decline to 50% of control at 4-48 h (P < 0.02) [12].

Chemical compound and disease context of Densitometry

  • Her evaluation revealed central diabetes insipidus, hypothalamic amenorrhea, an elevated free calcium on multiple occasions with an elevated 1,25 dihydroxyvitamin D level, and osteoporosis by densitometry [13].
  • METHODS: Whole body bone densitometry, estradiol (E2) levels, and biochemical bone markers (calcium, phosphorus, total alkaline phosphatase, tartrate-resistant acid phosphatase, and total proteins) were determined in 28 patients with endometriosis and compared with findings in 33 controls [14].
  • The amount of vasogenic edema produced was assessed by quantitation of the extravasation of Evans blue dye into the area of maximum blood-brain barrier breakdown by means of optical densitometry following formamide extraction [15].
  • The hybridized Dig-labeled probes are detected with an anti-Dig antibody conjugated to detector molecules for luminometry (aequorin) or optical densitometry (peroxidase), yielding results that are quantifiable over the range of 100-10,000 copies of HIV gag [16].
  • The efficiency of PPU was calculated from the increased leucine oxidation observed during feeding, and the apparent protein requirement was defined as metabolic demand/PPU and calculated in relation to both body weight (BW) and fat-free mass (FFM) determined by densitometry or bioimpedance [17].

Biological context of Densitometry


Anatomical context of Densitometry

  • The relative amounts of actin, tubulin, and neurofilament polypeptides in the operated ventral roots were measured by quantitative densitometry of stained two-dimensional electrophoretic gels [23].
  • Five of the six patients had NF1 gene deletions on the basis of quantitative densitometry, locus hemizygosity, and analysis of somatic cell hybrid lines [24].
  • Quantitation of the immunoreactive bands by video densitometry indicated that normal human neutrophils contain 1.5 +/- 0.8 ng DBP/10(6) cells (n = 9) [25].
  • Using quantitative densitometry of cDNA-hybridized RNA blots from cells isolated from crypts, villus middle (mid), or villus tip (tip), we found a 2- to 3-fold increase in villin, calmodulin and tropomyosin steady-state mRNA levels; an increase parallel to morphological brush border development [26].
  • Cooperative effects in the interaction between melittin and phosphatidylcholine model membranes. Studies by temperature scanning densitometry [27].

Associations of Densitometry with chemical compounds


Gene context of Densitometry

  • Using both densitometry and real-time quantitative polymerase chain reaction, we found that relative WT:MU IKBKAP RNA levels were highest in cultured patient lymphoblasts and lowest in postmortem central and peripheral nervous tissues [33].
  • In conclusion, PTH exerts an anabolic action at the tissue and cellular levels in intact mice and the magnitude and temporal pattern of this anabolic action, as assessed by densitometry and histomorphometry, are skeletal site specific [34].
  • These structural and functional changes were associated with significant decreases in renal nuclear SREBP-1 (5.2 in 24 m AL versus 3.3 densitometry units in 24 m CR; P < 0.01) and SREBP-2 (7.1 in 24 m AL versus 4.1 densitometry units in 24 m CR; P < 0.01) protein abundance and renal triglyceride and cholesterol contents [35].
  • Latent MMP-1, -2, -3, and -9 were detected by zymography and quantitated by densitometry, and production of all enzymes was increased on withdrawal of P [36].
  • Then, hybridization with 32P-labeled pE7 (a cDNA of EGFR), autoradiography, and densitometry were performed [37].

Analytical, diagnostic and therapeutic context of Densitometry


  1. Detection of Coxsackie-B-virus-specific RNA sequences in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy. Bowles, N.E., Richardson, P.J., Olsen, E.G., Archard, L.C. Lancet (1986) [Pubmed]
  2. Deletion of alpha-, beta-, and omega-interferon genes in malignant cells from children with acute lymphocytic leukemia. Einhorn, S., Grandér, D., Björk, O., Bröndum-Nielsen, K., Söderhäll, S. Cancer Res. (1990) [Pubmed]
  3. Bone loss in adults receiving alternate day glucocorticoid therapy. A comparison with daily therapy. Gluck, O.S., Murphy, W.A., Hahn, T.J., Hahn, B. Arthritis Rheum. (1981) [Pubmed]
  4. Cingulin, a specific protein component of tight junctions, is expressed in normal and neoplastic human epithelial tissues. Citi, S., Amorosi, A., Franconi, F., Giotti, A., Zampi, G. Am. J. Pathol. (1991) [Pubmed]
  5. Conjugated bile acids in serum and secretions in response to cholecystokinin/secretin stimulation in children with cystic fibrosis. Robb, T.A., Davidson, G.P., Kirubakaran, C. Gut (1985) [Pubmed]
  6. Allelic D variants of transferrin in evaluation of alcohol abuse: differential diagnosis by isoelectric focusing-immunoblotting-laser densitometry. Bean, P., Peter, J.B. Clin. Chem. (1994) [Pubmed]
  7. Decreased trkA gene expression within basal forebrain neurons in Alzheimer's disease. Mufson, E.J., Li, J.M., Sobreviela, T., Kordower, J.H. Neuroreport (1996) [Pubmed]
  8. Multiple-myeloma bone disease. The comparative effect of sodium fluoride and calcium carbonate or placebo. Kyle, R.A., Jowsey, J., Kelly, P.J., Taves, D.R. N. Engl. J. Med. (1975) [Pubmed]
  9. Bone mineral density in premenopausal women receiving long-term physiological doses of levothyroxine. Kung, A.W., Pun, K.K. JAMA (1991) [Pubmed]
  10. Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation. Choudhri, T.F., Hoh, B.L., Zerwes, H.G., Prestigiacomo, C.J., Kim, S.C., Connolly, E.S., Kottirsch, G., Pinsky, D.J. J. Clin. Invest. (1998) [Pubmed]
  11. Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex. Marples, D., Frøkiaer, J., Dørup, J., Knepper, M.A., Nielsen, S. J. Clin. Invest. (1996) [Pubmed]
  12. Regulation of calcium channel expression in neonatal myocytes by catecholamines. Maki, T., Gruver, E.J., Davidoff, A.J., Izzo, N., Toupin, D., Colucci, W., Marks, A.R., Marsh, J.D. J. Clin. Invest. (1996) [Pubmed]
  13. Hypercalcemia in Langerhans' cell granulomatosis with elevated 1,25 dihydroxyvitamin D (calcitriol) level. Al-Ali, H., Yabis, A.A., Issa, E., Salem, Z., Tawil, A., Khoury, N., Fuleihan, G.e.l.-.H. Bone (2002) [Pubmed]
  14. Total and regional bone mass values and biochemical markers of bone remodeling in endometriosis. Rico, H., Revilla, M., Arnanz, F., Villa, L.F., Perera, S., Arribas, I. Obstetrics and gynecology. (1993) [Pubmed]
  15. The influence of systemic arterial pressure and intracranial pressure on the development of cerebral vasogenic edema. Durward, Q.J., Del Maestro, R.F., Amacher, A.L., Farrar, J.K. J. Neurosurg. (1983) [Pubmed]
  16. Quantitative, competitive PCR assay for HIV-1 using a microplate-based detection system. Guenthner, P.C., Hart, C.E. BioTechniques (1998) [Pubmed]
  17. Protein requirements and ageing: metabolic demand and efficiency of utilization. Fereday, A., Gibson, N.R., Cox, M., Pacy, P.J., Millward, D.J. Br. J. Nutr. (1997) [Pubmed]
  18. Determination of the subunit composition of haptoglobin 2-1 polymers using quantitative densitometry of polyacrylamide gels. Hooper, D.C., Peacock, A.C. J. Biol. Chem. (1976) [Pubmed]
  19. Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome. Gwee, K.A., Collins, S.M., Read, N.W., Rajnakova, A., Deng, Y., Graham, J.C., McKendrick, M.W., Moochhala, S.M. Gut (2003) [Pubmed]
  20. Receptors of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in fetal and adult human kidney: localization and [125I]VEGF binding sites. Simon, M., Röckl, W., Hornig, C., Gröne, E.F., Theis, H., Weich, H.A., Fuchs, E., Yayon, A., Gröne, H.J. J. Am. Soc. Nephrol. (1998) [Pubmed]
  21. Kinetic aspects of synchrony in suspension cultures of Acer pseudoplatanus L. Gould, A.R., Street, H.E. J. Cell. Sci. (1975) [Pubmed]
  22. Six-month daily administration of parathyroid hormone and parathyroid hormone-related protein peptides to adult ovariectomized rats markedly enhances bone mass and biomechanical properties: a comparison of human parathyroid hormone 1-34, parathyroid hormone-related protein 1-36, and SDZ-parathyroid hormone 893. Stewart, A.F., Cain, R.L., Burr, D.B., Jacob, D., Turner, C.H., Hock, J.M. J. Bone Miner. Res. (2000) [Pubmed]
  23. Changes in the amounts of cytoskeletal proteins within the perikarya and axons of regenerating frog motoneurons. Sinicropi, D.V., McIlwain, D.L. J. Cell Biol. (1983) [Pubmed]
  24. Deletions spanning the neurofibromatosis 1 gene: identification and phenotype of five patients. Kayes, L.M., Burke, W., Riccardi, V.M., Bennett, R., Ehrlich, P., Rubenstein, A., Stephens, K. Am. J. Hum. Genet. (1994) [Pubmed]
  25. Localization and quantitation of the vitamin D binding protein (Gc-globulin) in human neutrophils. Kew, R.R., Sibug, M.A., Liuzzo, J.P., Webster, R.O. Blood (1993) [Pubmed]
  26. Cytoskeletal protein and mRNA accumulation during brush border formation in adult chicken enterocytes. Fath, K.R., Obenauf, S.D., Burgess, D.R. Development (1990) [Pubmed]
  27. Cooperative effects in the interaction between melittin and phosphatidylcholine model membranes. Studies by temperature scanning densitometry. Posch, M., Rakusch, U., Mollay, C., Laggner, P. J. Biol. Chem. (1983) [Pubmed]
  28. Regulation of glucose transporter-specific mRNA levels in rat adipose cells with fasting and refeeding. Implications for in vivo control of glucose transporter number. Kahn, B.B., Cushman, S.W., Flier, J.S. J. Clin. Invest. (1989) [Pubmed]
  29. Developmental regulation of transforming growth factor beta-mediated collagen synthesis in human intestinal muscle cells. Perr, H., Oh, P., Johnson, D. Gastroenterology (1996) [Pubmed]
  30. Structural and functional reconstitution of inner dynein arms in Chlamydomonas flagellar axonemes. Smith, E.F., Sale, W.S. J. Cell Biol. (1992) [Pubmed]
  31. Results of bone densitometry affect women's decisions about taking measures to prevent fractures. Rubin, S.M., Cummings, S.R. Ann. Intern. Med. (1992) [Pubmed]
  32. Cellular thin filament protein contents and force generation in porcine arteries and veins. Cohen, D.M., Murphy, R.A. Circ. Res. (1979) [Pubmed]
  33. Tissue-specific reduction in splicing efficiency of IKBKAP due to the major mutation associated with familial dysautonomia. Cuajungco, M.P., Leyne, M., Mull, J., Gill, S.P., Lu, W., Zagzag, D., Axelrod, F.B., Maayan, C., Gusella, J.F., Slaugenhaupt, S.A. Am. J. Hum. Genet. (2003) [Pubmed]
  34. Anabolic action of parathyroid hormone is skeletal site specific at the tissue and cellular levels in mice. Iida-Klein, A., Zhou, H., Lu, S.S., Levine, L.R., Ducayen-Knowles, M., Dempster, D.W., Nieves, J., Lindsay, R. J. Bone Miner. Res. (2002) [Pubmed]
  35. Calorie restriction modulates renal expression of sterol regulatory element binding proteins, lipid accumulation, and age-related renal disease. Jiang, T., Liebman, S.E., Lucia, M.S., Phillips, C.L., Levi, M. J. Am. Soc. Nephrol. (2005) [Pubmed]
  36. Production of endometrial matrix metalloproteinases, but not their tissue inhibitors, is modulated by progesterone withdrawal in an in vitro model for menstruation. Salamonsen, L.A., Butt, A.R., Hammond, F.R., Garcia, S., Zhang, J. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  37. Decrease in epidermal growth factor receptor and its messenger ribonucleic acid levels in intrauterine growth-retarded and diabetes mellitus-complicated pregnancies. Fujita, Y., Kurachi, H., Morishige, K., Amemiya, K., Terakawa, N., Miyake, A., Tanizawa, O. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  38. Apolipoprotein C-III(Lys58----Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia. von Eckardstein, A., Holz, H., Sandkamp, M., Weng, W., Funke, H., Assmann, G. J. Clin. Invest. (1991) [Pubmed]
  39. Steady-state levels of uroporphyrinogen decarboxylase mRNA in lymphoblastoid cell lines from patients with familial porphyria cutanea tarda and their relatives. Hansen, J.L., Pryor, M.A., Kennedy, J.B., Kushner, J.P. Am. J. Hum. Genet. (1988) [Pubmed]
  40. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Johnston, P.G., Lenz, H.J., Leichman, C.G., Danenberg, K.D., Allegra, C.J., Danenberg, P.V., Leichman, L. Cancer Res. (1995) [Pubmed]
  41. Distribution of N-nitrosomethylbenzylamine evaluated by whole-body radioautography and densitometry. Kraft, P.L., Tannenbaum, S.R. Cancer Res. (1980) [Pubmed]
  42. Endotoxin-stimulated monocytes release multiple forms of IL-1 beta, including a proIL-1 beta form whose detection is affected by export. Wewers, M.D., Winnard, A.V., Dare, H.A. J. Immunol. (1999) [Pubmed]
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