Gene Review:
UCP1 - uncoupling protein 1 (mitochondrial,...
Homo sapiens
Synonyms:
Mitochondrial brown fat uncoupling protein 1, SLC25A7, Solute carrier family 25 member 7, Thermogenin, UCP, ...
- Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes. Dalgaard, L.T., Pedersen, O. Diabetologia (2001)
- Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes. Rudofsky, G., Schroedter, A., Schlotterer, A., Voron'ko, O.E., Schlimme, M., Tafel, J., Isermann, B.H., Humpert, P.M., Morcos, M., Bierhaus, A., Nawroth, P.P., Hamann, A. Diabetes Care (2006)
- Activating omega-6 polyunsaturated fatty acids and inhibitory purine nucleotides are high affinity ligands for novel mitochondrial uncoupling proteins UCP2 and UCP3. Zackova, M., Skobisová, E., Urbánková, E., Jezek, P. J. Biol. Chem. (2003)
- Studies of genetic variability of the uncoupling protein 1 gene in Caucasian subjects with juvenile-onset obesity. Urhammer, S.A., Fridberg, M., Sørensen, T.I., Echwald, S.M., Andersen, T., Tybjaerg-Hansen, A., Clausen, J.O., Pedersen, O. J. Clin. Endocrinol. Metab. (1997)
- Interactions between physical activity and variants of the genes encoding uncoupling proteins -2 and -3 in relation to body weight changes during a 10-y follow-up. Berentzen, T., Dalgaard, L.T., Petersen, L., Pedersen, O., Sørensen, T.I. International journal of obesity (2005) (2005)
- Effects of fasting and food restriction on brown adipose tissue composition in normal and dystrophic hamsters. Desautels, M., Dulos, R.A., Yuen, H.M. Can. J. Physiol. Pharmacol. (1986)
- Brown adipose tissue: function and physiological significance. Cannon, B., Nedergaard, J. Physiol. Rev. (2004)
- Cold-induced thermoregulation and biological aging. Florez-Duquet, M., McDonald, R.B. Physiol. Rev. (1998)
- Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Levi-Meyrueis, C., Bouillaud, F., Seldin, M.F., Surwit, R.S., Ricquier, D., Warden, C.H. Nat. Genet. (1997)
- Synergistic effect of polymorphisms of uncoupling protein 1 and beta3-adrenergic receptor genes on autonomic nervous system activity. Shihara, N., Yasuda, K., Moritani, T., Ue, H., Uno, M., Adachi, T., Nunoi, K., Seino, Y., Yamada, Y., Tsuda, K. Int. J. Obes. Relat. Metab. Disord. (2001)
- Decreased uncoupling protein expression and intramyocytic triglyceride depletion in formerly obese subjects. Mingrone, G., Rosa, G., Greco, A.V., Manco, M., Vega, N., Hesselink, M.K., Castagneto, M., Schrauwen, P., Vidal, H. Obes. Res. (2003)
- The effects of norephedrine and bethanechol on the human urethral closure pressure profile. Ek, A., Andersson, K.E., Ulmsten, U. Scandinavian journal of urology and nephrology. (1978)
- Recent developments in chest pain of undetermined origin. Achem, S.R., DeVault, K.R. Current gastroenterology reports. (2000)
- Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans. Millet, L., Vidal, H., Andreelli, F., Larrouy, D., Riou, J.P., Ricquier, D., Laville, M., Langin, D. J. Clin. Invest. (1997)
- The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Ricquier, D., Bouillaud, F. Biochem. J. (2000)
- Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. Boss, O., Samec, S., Paoloni-Giacobino, A., Rossier, C., Dulloo, A., Seydoux, J., Muzzin, P., Giacobino, J.P. FEBS Lett. (1997)
- Fatty acid interaction with mitochondrial uncoupling proteins. Jezek, P. J. Bioenerg. Biomembr. (1999)
- Uncoupling protein--a useful energy dissipator. Klingenberg, M. J. Bioenerg. Biomembr. (1999)
- A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. Echtay, K.S., Esteves, T.C., Pakay, J.L., Jekabsons, M.B., Lambert, A.J., Portero-Otín, M., Pamplona, R., Vidal-Puig, A.J., Wang, S., Roebuck, S.J., Brand, M.D. EMBO J. (2003)
- Human uncoupling proteins and obesity. Schrauwen, P., Walder, K., Ravussin, E. Obes. Res. (1999)
- Genomic organization and mutational analysis of the human UCP2 gene, a prime candidate gene for human obesity. Lentes, K.U., Tu, N., Chen, H., Winnikes, U., Reinert, I., Marmann, G., Pirke, K.M. J. Recept. Signal Transduct. Res. (1999)
- The role of uncoupling proteins in pathophysiological states. Argilés, J.M., Busquets, S., López-Soriano, F.J. Biochem. Biophys. Res. Commun. (2002)
- Tissue-specific activity of lipoprotein lipase in skeletal muscle regulates the expression of uncoupling protein 3 in transgenic mouse models. Kratky, D., Strauss, J.G., Zechner, R. Biochem. J. (2001)
- Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10. Jaburek, M., Garlid, K.D. J. Biol. Chem. (2003)
- Expression modification of uncoupling proteins and MnSOD in retinal endothelial cells and pericytes induced by high glucose: The role of reactive oxygen species in diabetic retinopathy. Cui, Y., Xu, X., Bi, H., Zhu, Q., Wu, J., Xia, X., Qiushi Ren, n.u.l.l., Ho, P.C. Exp. Eye Res. (2006)
- Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose. Mozo, J., Ferry, G., Studeny, A., Pecqueur, C., Rodriguez, M., Boutin, J.A., Bouillaud, F. Biochem. J. (2006)
- The significance and mechanism of mitochondrial proton conductance. Brand, M.D., Brindle, K.M., Buckingham, J.A., Harper, J.A., Rolfe, D.F., Stuart, J.A. Int. J. Obes. Relat. Metab. Disord. (1999)
- The biology of mitochondrial uncoupling proteins. Rousset, S., Alves-Guerra, M.C., Mozo, J., Miroux, B., Cassard-Doulcier, A.M., Bouillaud, F., Ricquier, D. Diabetes (2004)
- Control of beta 3-adrenergic receptor gene expression in brown adipocytes in culture. Klaus, S., Muzzin, P., Revelli, J.P., Cawthorne, M.A., Giacobino, J.P., Ricquier, D. Mol. Cell. Endocrinol. (1995)
- The mitochondrial uncoupling-protein homologues. Krauss, S., Zhang, C.Y., Lowell, B.B. Nat. Rev. Mol. Cell Biol. (2005)
- Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone). Echtay, K.S., Winkler, E., Frischmuth, K., Klingenberg, M. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Specific sequence of motifs of mitochondrial uncoupling proteins. Jezek, P., Urbánková, E. IUBMB Life (2000)
- Mitochondrial uncoupling as a target for drug development for the treatment of obesity. Harper, J.A., Dickinson, K., Brand, M.D. Obesity reviews : an official journal of the International Association for the Study of Obesity. (2001)
- Effects of growth hormone (GH) on mRNA levels of uncoupling proteins 1, 2, and 3 in brown and white adipose tissues and skeletal muscle in obese mice. Hioki, C., Yoshida, T., Kogure, A., Takakura, Y., Umekawa, T., Yoshioka, K., Shimatsu, A., Yoshikawa, T. Horm. Metab. Res. (2004)
- Mitochondrial proliferation, DNA depletion and adipocyte differentiation in subcutaneous adipose tissue of HIV-positive HAART recipients. Pace, C.S., Martin, A.M., Hammond, E.L., Mamotte, C.D., Nolan, D.A., Mallal, S.A. Antivir. Ther. (Lond.) (2003)
- Physiological effects of variants in human uncoupling proteins: UCP2 influences body-mass index. Schonfeld-Warden, N.A., Warden, C.H. Biochem. Soc. Trans. (2001)