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RGS10  -  regulator of G-protein signaling 10

Homo sapiens

Synonyms: Regulator of G-protein signaling 10
 
 
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Disease relevance of RGS10

 

High impact information on RGS10

  • Co-immunoprecipitation studies demonstrate that RGS10 associates specifically with the activated forms of two related G-protein subunits, G alphai3, and G alphaz, but fails to interact with the structurally and functionally distinct G alphas subunit [2].
  • The extent of inhibition of Gz GAP, GAIP, RGS4, and RGS10 correlated roughly with their intrinsic GAP activities for the Galpha target used in the assay [3].
  • We also found weaker evidence supporting the possible involvement of the GRK5/RGS10 locus in ARM [4].
  • These studies also provided the first demonstration of posttranslational modification of 2 regulator of G protein signaling (RGS) proteins, RGS10 and 18 [5].
  • Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10) [6].
 

Biological context of RGS10

  • We observed maximum inhibition of GnRH-stimulated IP responses by RGS3 and by the conserved domain of RGS10 at both 48 and 72 h after transfection, indicating their involvement in G(q)alpha mediated signaling [7].
  • Sequence analysis revealed that the RGS10 gene encompasses six exons spanning more than 40 kb of genomic DNA [8].
 

Anatomical context of RGS10

 

Associations of RGS10 with chemical compounds

  • We have previously shown that melatonin and the cell permeable cGMP analog 8-bromo cGMP, which lead to protein kinase C (PKC) activation, enhanced cytoplasmic distribution of RGS10 and RGS2 in prostate carcinoma PC3-AR cells [9].
  • Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10 [10].
  • Palmitic acid incorporation into RGS3 was dependent on agonist occupancy of GnRHR, whereas palmitoylation of RGS10 was constitutive [7].
 

Other interactions of RGS10

  • Significantly diminished cAMP production was observed at all times when cells overexpressed the conserved domain of RGS10; no effect was observed with RGS3 on G(s)alpha-mediated signaling [7].
 

Analytical, diagnostic and therapeutic context of RGS10

References

  1. Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs. Chatterjee, T.K., Fisher, R.A. J. Biol. Chem. (2000) [Pubmed]
  2. RGS10 is a selective activator of G alpha i GTPase activity. Hunt, T.W., Fields, T.A., Casey, P.J., Peralta, E.G. Nature (1996) [Pubmed]
  3. Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits. Tu, Y., Wang, J., Ross, E.M. Science (1997) [Pubmed]
  4. Susceptibility genes for age-related maculopathy on chromosome 10q26. Jakobsdottir, J., Conley, Y.P., Weeks, D.E., Mah, T.S., Ferrell, R.E., Gorin, M.B. Am. J. Hum. Genet. (2005) [Pubmed]
  5. Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins. García, A., Prabhakar, S., Hughan, S., Anderson, T.W., Brock, C.J., Pearce, A.C., Dwek, R.A., Watson, S.P., Hebestreit, H.F., Zitzmann, N. Blood (2004) [Pubmed]
  6. Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). Burgon, P.G., Lee, W.L., Nixon, A.B., Peralta, E.G., Casey, P.J. J. Biol. Chem. (2001) [Pubmed]
  7. Regulation of RGS3 and RGS10 palmitoylation by GnRH. Castro-Fernández, C., Janovick, J.A., Brothers, S.P., Fisher, R.A., Ji, T.H., Conn, P.M. Endocrinology (2002) [Pubmed]
  8. Structure, chromosomal localization and expression of the mouse regulator of G-protein signaling10 gene (mRGS10). Haller, C., Fillatreau, S., Hoffmann, R., Agenès, F. Gene (2002) [Pubmed]
  9. Differential effects of melatonin and its downstream effector PKCalpha on subcellular localization of RGS proteins. Rimler, A., Jockers, R., Lupowitz, Z., Sampson, S.R., Zisapel, N. J. Pineal Res. (2006) [Pubmed]
  10. Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10. Tu, Y., Popov, S., Slaughter, C., Ross, E.M. J. Biol. Chem. (1999) [Pubmed]
  11. Crystallization and preliminary X-ray crystallographic analysis of human RGS10 complexed with Galphai3. Lee, H.K., Rhee, K.H., Kim, C.W., Hwang, K.Y., Kim, E.E. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2005) [Pubmed]
 
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