Gene Review:
GRK5 - G protein-coupled receptor kinase 5
Homo sapiens
Synonyms:
G protein-coupled receptor kinase GRK5, GPRK5
- Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family. Kunapuli, P., Benovic, J.L. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Differential functional expression of human myocardial G protein receptor kinases in left ventricular cardiac diseases. Dzimiri, N., Muiya, P., Andres, E., Al-Halees, Z. Eur. J. Pharmacol. (2004)
- Enhanced GRK5 expression in the hearts of cardiomyopathic hamsters, J2N-k. Takagi, C., Urasawa, K., Yoshida, I., Takagi, Y., Kaneta, S., Nakano, N., Onozuka, H., Kitabatake, A. Biochem. Biophys. Res. Commun. (1999)
- The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease. Arawaka, S., Wada, M., Goto, S., Karube, H., Sakamoto, M., Ren, C.H., Koyama, S., Nagasawa, H., Kimura, H., Kawanami, T., Kurita, K., Tajima, K., Daimon, M., Baba, M., Kido, T., Saino, S., Goto, K., Asao, H., Kitanaka, C., Takashita, E., Hongo, S., Nakamura, T., Kayama, T., Suzuki, Y., Kobayashi, K., Katagiri, T., Kurokawa, K., Kurimura, M., Toyoshima, I., Niizato, K., Tsuchiya, K., Iwatsubo, T., Muramatsu, M., Matsumine, H., Kato, T. J. Neurosci. (2006)
- Inhibition of constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor by protein kinases in mammalian cells in culture. Geras-Raaka, E., Arvanitakis, L., Bais, C., Cesarman, E., Mesri, E.A., Gershengorn, M.C. J. Exp. Med. (1998)
- Susceptibility genes for age-related maculopathy on chromosome 10q26. Jakobsdottir, J., Conley, Y.P., Weeks, D.E., Mah, T.S., Ferrell, R.E., Gorin, M.B. Am. J. Hum. Genet. (2005)
- G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells. Tiruppathi, C., Yan, W., Sandoval, R., Naqvi, T., Pronin, A.N., Benovic, J.L., Malik, A.B. Proc. Natl. Acad. Sci. U.S.A. (2000)
- G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence. Johnson, L.R., Scott, M.G., Pitcher, J.A. Mol. Cell. Biol. (2004)
- Regulation of G-protein-coupled receptor kinase subtypes by calcium sensor proteins. Iacovelli, L., Sallese, M., Mariggiò, S., de Blasi, A. FASEB J. (1999)
- Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation. Pronin, A.N., Carman, C.V., Benovic, J.L. J. Biol. Chem. (1998)
- Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5. Kunapuli, P., Onorato, J.J., Hosey, M.M., Benovic, J.L. J. Biol. Chem. (1994)
- Involvement of G protein-coupled receptor kinase 5 in homologous desensitization of the thyrotropin receptor. Nagayama, Y., Tanaka, K., Hara, T., Namba, H., Yamashita, S., Taniyama, K., Niwa, M. J. Biol. Chem. (1996)
- G protein-coupled receptor kinase specificity for phosphorylation and desensitization of alpha2-adrenergic receptor subtypes. Jewell-Motz, E.A., Liggett, S.B. J. Biol. Chem. (1996)
- Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation. Arraes, S.M., Freitas, M.S., da Silva, S.V., de Paula Neto, H.A., Alves-Filho, J.C., Martins, M.A., Basile-Filho, A., Tavares-Murta, B.M., Barja-Fidalgo, C., Cunha, F.Q. Blood (2006)
- Regulation of G protein-coupled receptor kinases by calmodulin and localization of the calmodulin binding domain. Pronin, A.N., Satpaev, D.K., Slepak, V.Z., Benovic, J.L. J. Biol. Chem. (1997)
- Arrestin-2 and G Protein-coupled Receptor Kinase 5 Interact with NF{kappa}B1 p105 and Negatively Regulate Lipopolysaccharide-stimulated ERK1/2 Activation in Macrophages. Parameswaran, N., Pao, C.S., Leonhard, K.S., Kang, D.S., Kratz, M., Ley, S.C., Benovic, J.L. J. Biol. Chem. (2006)
- Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro. Warabi, K., Richardson, M.D., Barry, W.T., Yamaguchi, K., Roush, E.D., Nishimura, K., Kwatra, M.M. FEBS Lett. (2002)
- Desensitization of beta2-adrenergic receptors with mutations of the proposed G protein-coupled receptor kinase phosphorylation sites. Seibold, A., January, B.G., Friedman, J., Hipkin, R.W., Clark, R.B. J. Biol. Chem. (1998)
- A predicted amphipathic helix mediates plasma membrane localization of GRK5. Thiyagarajan, M.M., Stracquatanio, R.P., Pronin, A.N., Evanko, D.S., Benovic, J.L., Wedegaertner, P.B. J. Biol. Chem. (2004)
- G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95. Hu, L.A., Chen, W., Premont, R.T., Cong, M., Lefkowitz, R.J. J. Biol. Chem. (2002)
- Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6. Loudon, R.P., Benovic, J.L. J. Biol. Chem. (1994)
- Molecular pharmacology and modeling of vasopressin receptors. Thibonnier, M., Coles, P., Thibonnier, A., Shoham, M. Prog. Brain Res. (2002)
- Development of a yeast bioassay to characterize G protein-coupled receptor kinases. Identification of an NH2-terminal region essential for receptor phosphorylation. Noble, B., Kallal, L.A., Pausch, M.H., Benovic, J.L. J. Biol. Chem. (2003)
- Endosome sorting of beta 2-adrenoceptors is GRK5 independent. Millman, E.E., Rosenfeld, J.L., Vaughan, D.J., Nguyen, J., Dai, W., Alpizar-Foster, E., Clark, R.B., Knoll, B.J., Moore, R.H. Br. J. Pharmacol. (2004)
- Lymphocyte levels of GRK2 (betaARK1) mirror changes in the LVAD-supported failing human heart: lower GRK2 associated with improved beta-adrenergic signaling after mechanical unloading. Hata, J.A., Williams, M.L., Schroder, J.N., Lima, B., Keys, J.R., Blaxall, B.C., Petrofski, J.A., Jakoi, A., Milano, C.A., Koch, W.J. J. Card. Fail. (2006)