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Gene Review

Mapk12  -  mitogen-activated protein kinase 12

Rattus norvegicus

Synonyms: ERK-6, Extracellular signal-regulated kinase 6, MAP kinase 12, MAP kinase p38 gamma, MAPK 12, ...
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High impact information on Mapk12


Biological context of Mapk12

  • This is a new mechanism for the regulation of SAPK3 and suggests that its intracellular activity should not be solely assessed by its phosphorylation status [4].
  • Rat ERK6, also known as SAPK3 and p38gamma, exhibits a distinct pattern of expression during muscle development in vitro and in vivo [5].
  • With the exception of p38gamma/ERK6, the concentration of each signal transduction protein was uniformly higher in one muscle than in the other in all four animals [6].

Anatomical context of Mapk12

  • This latter protein is localised together with SAPK3 at the mitochondria but it is not a SAPK3 substrate [4].
  • ERK6 is expressed in a developmentally regulated manner in rodent skeletal muscle [5].
  • Similar results are observed in vivo where ERK6 mRNA levels increase with post-natal development in rat hindlimb mixed muscle samples [5].
  • Levels of mRNA transcript and protein abundance for ERK6 are increased during the differentiation of 2 rodent myoblast cell lines in culture [5].
  • Immunolocalization in cultured cardiac myocytes followed by confocal microscopy showed punctate, non-nuclear SAPK3 staining [2].

Analytical, diagnostic and therapeutic context of Mapk12

  • We have generated monoclonal antibodies with specificity for SAPK3 demonstrated by immunoblot analysis, immunofluorescence studies, and cloning of SAPK3 from a rat heart cDNA expression library [2].


  1. Microarray analysis of gene expression in the rat vestibular nucleus complex following unilateral vestibular deafferentation. Horii, A., Masumura, C., Smith, P.F., Darlington, C.L., Kitahara, T., Uno, A., Mitani, K., Kubo, T. J. Neurochem. (2004) [Pubmed]
  2. Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3). Court, N.W., dos Remedios, C.G., Cordell, J., Bogoyevitch, M.A. J. Mol. Cell. Cardiol. (2002) [Pubmed]
  3. Dehydroepiandrosterone antagonizes the neurotoxic effects of corticosterone and translocation of stress-activated protein kinase 3 in hippocampal primary cultures. Kimonides, V.G., Spillantini, M.G., Sofroniew, M.V., Fawcett, J.W., Herbert, J. Neuroscience (1999) [Pubmed]
  4. Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3. Court, N.W., Ingley, E., Klinken, S.P., Bogoyevitch, M.A. Biochim. Biophys. Acta (2005) [Pubmed]
  5. ERK6 is expressed in a developmentally regulated manner in rodent skeletal muscle. Tortorella, L.L., Lin, C.B., Pilch, P.F. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  6. Concentrations of signal transduction proteins exercise and insulin responses in rat extensor digitorum longus and soleus muscles. Atherton, P.J., Higginson, J.M., Singh, J., Wackerhage, H. Mol. Cell. Biochem. (2004) [Pubmed]
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