Gene Review:
MAPK12 - mitogen-activated protein kinase 12
Homo sapiens
Synonyms:
ERK-6, ERK3, ERK6, Extracellular signal-regulated kinase 6, MAP kinase 12, ...
- Global gene expression analysis of ERK5 and ERK1/2 signaling reveals a role for HIF-1 in ERK5-mediated responses. Schweppe, R.E., Cheung, T.H., Ahn, N.G. J. Biol. Chem. (2006)
- Essential role of p38gamma in K-Ras transformation independent of phosphorylation. Tang, J., Qi, X., Mercola, D., Han, J., Chen, G. J. Biol. Chem. (2005)
- Intensity-dependent activation of extracellular signal-regulated protein kinase 5 in sensory neurons contributes to pain hypersensitivity. Mizushima, T., Obata, K., Katsura, H., Sakurai, J., Kobayashi, K., Yamanaka, H., Dai, Y., Fukuoka, T., Mashimo, T., Noguchi, K. J. Pharmacol. Exp. Ther. (2007)
- Cisplatin and UV radiation induce activation of the stress-activated protein kinase p38gamma in human melanoma cells. Pillaire, M.J., Nebreda, A.R., Darbon, J.M. Biochem. Biophys. Res. Commun. (2000)
- Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. Kato, Y., Tapping, R.I., Huang, S., Watson, M.H., Ulevitch, R.J., Lee, J.D. Nature (1998)
- Spatiotemporal Regulation of c-Fos by ERK5 and the E3 Ubiquitin Ligase UBR1, and Its Biological Role. Sasaki, T., Kojima, H., Kishimoto, R., Ikeda, A., Kunimoto, H., Nakajima, K. Mol. Cell (2006)
- Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). Cuenda, A., Cohen, P., Buée-Scherrer, V., Goedert, M. EMBO J. (1997)
- Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. Wang, X., McGowan, C.H., Zhao, M., He, L., Downey, J.S., Fearns, C., Wang, Y., Huang, S., Han, J. Mol. Cell. Biol. (2000)
- The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway. Tosti, E., Waldbaum, L., Warshaw, G., Gross, E.A., Ruggieri, R. J. Biol. Chem. (2004)
- Induction of apoptosis in renal cell carcinoma by reactive oxygen species: involvement of extracellular signal-regulated kinase 1/2, p38delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor. Ambrose, M., Ryan, A., O'Sullivan, G.C., Dunne, C., Barry, O.P. Mol. Pharmacol. (2006)
- Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases. Goedert, M., Hasegawa, M., Jakes, R., Lawler, S., Cuenda, A., Cohen, P. FEBS Lett. (1997)
- ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. Lechner, C., Zahalka, M.A., Giot, J.F., Møller, N.P., Ullrich, A. Proc. Natl. Acad. Sci. U.S.A. (1996)
- p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle. Ho, R.C., Alcazar, O., Fujii, N., Hirshman, M.F., Goodyear, L.J. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004)
- Structure of GSK3beta reveals a primed phosphorylation mechanism. ter Haar, E., Coll, J.T., Austen, D.A., Hsiao, H.M., Swenson, L., Jain, J. Nat. Struct. Biol. (2001)
- Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. Hasegawa, M., Cuenda, A., Spillantini, M.G., Thomas, G.M., Buée-Scherrer, V., Cohen, P., Goedert, M. J. Biol. Chem. (1999)
- Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength. Alonso, G., Ambrosino, C., Jones, M., Nebreda, A.R. J. Biol. Chem. (2000)
- Contributions of the mitogen-activated protein (MAP) kinase backbone and phosphorylation loop to MEK specificity. Robinson, M.J., Cheng, M., Khokhlatchev, A., Ebert, D., Ahn, N., Guan, K.L., Stein, B., Goldsmith, E., Cobb, M.H. J. Biol. Chem. (1996)
- p38gamma mitogen-activated protein kinase integrates signaling crosstalk between Ras and estrogen receptor to increase breast cancer invasion. Qi, X., Tang, J., Loesch, M., Pohl, N., Alkan, S., Chen, G. Cancer Res. (2006)
- Inhibition of TRAIL-induced apoptosis by IL-8 is mediated by the p38-MAPK pathway in OVCAR3 cells. Abdollahi, T., Robertson, N.M., Abdollahi, A., Litwack, G. Apoptosis (2005)
- MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway. Chao, T.H., Hayashi, M., Tapping, R.I., Kato, Y., Lee, J.D. J. Biol. Chem. (1999)
- Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization. Goedert, M., Hasegawa, J., Craxton, M., Leversha, M.A., Clegg, S. Genomics (1997)
- Phosphorylation of cytosolic phospholipase A2 in platelets is mediated by multiple stress-activated protein kinase pathways. Börsch-Haubold, A.G., Ghomashchi, F., Pasquet, S., Goedert, M., Cohen, P., Gelb, M.H., Watson, S.P. Eur. J. Biochem. (1999)
- Preconditioning-induced activation of ERK5 is dependent on moderate Ca(2+) influx via NMDA receptors and contributes to ischemic tolerance in the hippocampal CA1 region of rats. Wang, R.M., Yang, F., Zhang, Y.X. Life Sci. (2006)