Disease relevance of RPL13

• The absence of tumour-specific mutations in CMAR and BBC1 in this selected series of breast tumours implies that another gene at 16q24.3 must be the tumour-suppressor gene that is the target for LOH in breast cancer [1].
• Activation of the ribosomal protein L13 gene in human gastrointestinal cancer [2].

High impact information on RPL13

• In addition, reduced RNA expression of two other genes at 8E1 encoding COX4I1 and RPL13 could be explained by a decrease in chromosomal copy number on chromosome 8 [3].
• In the BBC1 gene, three different alterations were found, but only one resulted in an amino acid substitution [1].
• Expression levels were restored to normal particularly in four types of mRNAs, which were matched with sequences encoding eukaryotic translation initiation factor 4A1 (eIF4A1), ribosomal protein L13, mediator of RNA polymerase to transcription (MRT) and ribosomal phosphoprotein PO [4].
• In our earlier study, we showed that ribosomal protein L13 mRNA was up-regulated in response to DNA damage in hamster cells [2].
• We show that the D16S444E gene is localized on band 16q24.3 and is located between APRT and D16S44 [5].

Biological context of RPL13

• Mapping of the breast basic conserved gene (D16S444E) to human chromosome band 16q24.3 [5].
• The breast basic conserved gene (D16S444E) is a candidate tumor suppressor gene previously mapped to human chromosome 16 [5].
• We determined the map position of D16S444E more precisely using a somatic mouse x human hybrid panel and fluorescence in situ hybridization on metaphase spreads and interphase nuclei [5].
• The Schistosoma mansoni gene sequence encoding the breast basic conserved protein 1/ribosomal protein L13 has been isolated from an adult worm cDNA library using the Expressed Sequence Tag strategy [6].

References