High impact information on RPS13

• RPS13 and RPL23 were genetically overexpressed in SGC7901 cells, respectively [1].
• Either RPS13 or RPL23 enhanced resistance of SGC7901 cells to vincristine, adriamycin, and 5-fludrouracil [1].
• However, either RPS13 or RPL23 could protect SGC7901 cells from undergoing vincristine-induced apoptosis [1].
• The complete amino acid sequence of a cytoplasmic ribosomal protein S13 of maize was deduced from the cDNA isolated from a maize cDNA library [2].
• cDNA nucleotide sequence and expression of a maize cytoplasmic ribosomal protein S13 gene [2].

Biological context of RPS13

• U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene [3].
• The predicted protein encoded by this gene is identical to the human ribosomal protein S13, except for one amino acid substitution at residue 29, which is an alanine in the hamster protein and a threonine in that of humans [4].
• No RNA editing of rps13 mRNAs is required in Amaryllidaceae, because all respective genomic sequences resemble the edited version of the mRNAs of other analysed land plants [5].
• Both editing pattern and efficiency of RNA editing differ in the reverse transcription (RT)-PCR-derived cDNA populations from the rps13 locus from the analyzed plant species with only the Magnolia rps13 being fully edited [6].
• To obtain information on ribosomal protein gene content and RNA editing in plant mitochondria, we investigated the conservation of the gene for ribosomal protein S13 (rps13) in the mitochondrial genomes of Magnolia spp. and Helianthus annuus [6].

Anatomical context of RPS13

• We have cloned and sequenced the ribosomal protein S13 gene from the Chinese hamster fibroblast HA-1 cells [4].
• RNA editing of the ribosomal protein S13 transcripts in magnolia and sunflower mitochondria [6].

Associations of RPS13 with chemical compounds

• Transcripts from the rps13 locus, which encodes ribosomal protein S13, in Oenothera and Daucus mitochondria are edited by several cytidine to uridine transitions in both plants [7].

Other interactions of RPS13

• PROSITE analysis of the ribosomal protein S18 in eukaryote revealed homology with prokaryotic ribosomal protein S13 signature, which is known to be involved in the initiation of translation [8].

Analytical, diagnostic and therapeutic context of RPS13

• Western blot analysis revealed that both RPS13 and RPL23 significantly increased the expression level of Bcl-2 and Bcl-2/Bax ratio in SGC7901 cells [1].

References