Disease relevance of Liliaceae

• Mannose-specific plant lectins from the Amaryllidaceae family qualify as efficient microbicides for prevention of human immunodeficiency virus infection [1].

High impact information on Liliaceae

• The plant lectins from Hippeastrum hybrid (HHA) and Galanthus nivalis (GNA) are 50,000-D tetramers showing specificity for alpha-(1,3) and/or alpha-(1,6)-mannose oligomers [2].
• Muscarine, imidazole, oxazole, thiazole, Amaryllidaceae and Sceletium alkaloids [3].
• Amaryllidaceae, sceletium, imidazole, oxazole, thiazole, peptide and miscellaneous alkaloids [4].
• A review with 136 references covers the literature from July 2000 to June 2001 on the isolation, bioactivities, and synthetic highlights of complex natural products including muscarine, imidazole, oxazole, thiazole, Amaryllidaceae and Sceletium alkaloids [3].
• The mannose-specific plant lectins from Galanthus, Hippeastrum, Narcissus, Epipac tis helleborine, and Listera ovata, and the N-acetylgl ucosamine-specific lectin from Urtica dioica would primarily be targeted at the virus-cell fusion process [5].

Chemical compound and disease context of Liliaceae

• BACKGROUND: Galanthus nivalis agglutinin (GNA), a mannose-specific lectin from snowdrop bulbs, is a tetrameric member of the family of Amaryllidaceae lectins that exhibit antiviral activity towards HIV [6].

Biological context of Liliaceae

• DNA sequences of the rbcL gene were analyzed for 8 species from Trilliaceae sensu lato (Trillium kamtschaticum, T. sessile, Daiswa polyphylla, Kinugasa japonica, Paris tetraphylla, Scoliopus bigelovii, S. hallii, and Medeola virginiana) and 10 other species from Liliaceae sensu lato [7].
• Three mannose-specific lectins exhibiting considerable similarities in NH2-terminal amino acid sequence were isolated from leaves of the Chinese daffodil Narcissus tazetta (Family Amaryllidaceae) [8].

Associations of Liliaceae with chemical compounds

• Galanthus nivalis agglutinin (GNA, a 50 kDa tetramer) is a mannose-specific lectin of the Amaryllidaceae family of bulb lectins [9].
• Genetic analysis of male reproductive contributions in Chamaelirium luteum (L.) gray (Liliaceae) [10].
• The phenanthridine alkaloid lycobetaine is a minor constituent of Amaryllidaceae [11].
• Total synthesis of Amaryllidaceae alkaloids utilizing sequential intramolecular heterocyclic azadiene Diels-Alder reactions of an unsymmetrical 1,2,4,5-tetrazine [12].
• Inhibition of [3H]citalopram binding to the rat brain serotonin transporter by Amaryllidaceae alkaloids [13].

Gene context of Liliaceae

• Primary transcripts of ndhD of Liliaceae and Aloaceae require editing of the start and 20th codons [14].
• Rhizomes of five identified plants of the Paris species, Liliaceae, and Rhizoma Paridis which are sold as a crude drug named "Zao Xiu," "Qiyeyizhihua" or other names in nine different markets in China were tested for their effects on cultured cardiomyocytes [15].
• Twenty of 23 primer pairs were also functional in three monocot species of the Liliaceae [onion (Allium cepa L.) and garlic (Allium sativum L.)], and the Poaceae [oat (Avena sativa L.)] [16].
• Phytochemical investigation of Hippeastrum vittatum growing in Egypt. Part II. Isolation and identification of new alkaloids [17].
• Antiplasmodial and antioxidant isofuranonaphthoquinones from the roots of Bulbine capitata [18].

Analytical, diagnostic and therapeutic context of Liliaceae

• Molecular cloning of mannose-binding lectins from Clivia miniata [19].
• (Liliaceae, "Hon-Gyoujya Nin-Niku" in Japanese) was successively extracted with hexane, acetone, methanol and 70% methanol and the extracts were further separated into a total of twenty-five fractions by silica gel and ODS column chromatographies [20].
• N-terminal sequence analysis revealed its remarkable homology to Allium cepa lectin and similarity to a lesser extent to lectins from members of the Amaryllidaceae, Orchidaceae, and Liliaceae [21].

References