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Disease relevance of Liliaceae


High impact information on Liliaceae


Chemical compound and disease context of Liliaceae

  • BACKGROUND: Galanthus nivalis agglutinin (GNA), a mannose-specific lectin from snowdrop bulbs, is a tetrameric member of the family of Amaryllidaceae lectins that exhibit antiviral activity towards HIV [6].

Biological context of Liliaceae

  • DNA sequences of the rbcL gene were analyzed for 8 species from Trilliaceae sensu lato (Trillium kamtschaticum, T. sessile, Daiswa polyphylla, Kinugasa japonica, Paris tetraphylla, Scoliopus bigelovii, S. hallii, and Medeola virginiana) and 10 other species from Liliaceae sensu lato [7].
  • Three mannose-specific lectins exhibiting considerable similarities in NH2-terminal amino acid sequence were isolated from leaves of the Chinese daffodil Narcissus tazetta (Family Amaryllidaceae) [8].

Associations of Liliaceae with chemical compounds


Gene context of Liliaceae

  • Primary transcripts of ndhD of Liliaceae and Aloaceae require editing of the start and 20th codons [14].
  • Rhizomes of five identified plants of the Paris species, Liliaceae, and Rhizoma Paridis which are sold as a crude drug named "Zao Xiu," "Qiyeyizhihua" or other names in nine different markets in China were tested for their effects on cultured cardiomyocytes [15].
  • Twenty of 23 primer pairs were also functional in three monocot species of the Liliaceae [onion (Allium cepa L.) and garlic (Allium sativum L.)], and the Poaceae [oat (Avena sativa L.)] [16].
  • Phytochemical investigation of Hippeastrum vittatum growing in Egypt. Part II. Isolation and identification of new alkaloids [17].
  • Antiplasmodial and antioxidant isofuranonaphthoquinones from the roots of Bulbine capitata [18].

Analytical, diagnostic and therapeutic context of Liliaceae


  1. Mannose-specific plant lectins from the Amaryllidaceae family qualify as efficient microbicides for prevention of human immunodeficiency virus infection. Balzarini, J., Hatse, S., Vermeire, K., Princen, K., Aquaro, S., Perno, C.F., De Clercq, E., Egberink, H., Vanden Mooter, G., Peumans, W., Van Damme, E., Schols, D. Antimicrob. Agents Chemother. (2004) [Pubmed]
  2. Marked depletion of glycosylation sites in HIV-1 gp120 under selection pressure by the mannose-specific plant lectins of Hippeastrum hybrid and Galanthus nivalis. Balzarini, J., Van Laethem, K., Hatse, S., Froeyen, M., Van Damme, E., Bolmstedt, A., Peumans, W., De Clercq, E., Schols, D. Mol. Pharmacol. (2005) [Pubmed]
  3. Muscarine, imidazole, oxazole, thiazole, Amaryllidaceae and Sceletium alkaloids. Jin, Z., Li, Z., Huang, R. Natural product reports. (2002) [Pubmed]
  4. Amaryllidaceae, sceletium, imidazole, oxazole, thiazole, peptide and miscellaneous alkaloids. Lewis, J.R. Natural product reports. (2002) [Pubmed]
  5. Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection. De Clercq, E. Medicinal research reviews. (2000) [Pubmed]
  6. The 2.0 A structure of a cross-linked complex between snowdrop lectin and a branched mannopentaose: evidence for two unique binding modes. Wright, C.S., Hester, G. Structure (1996) [Pubmed]
  7. Molecular systematics of the Trilliaceae sensu lato as inferred from rbcL sequence data. Kato, H., Terauchi, R., Utech, F.H., Kawano, S. Mol. Phylogenet. Evol. (1995) [Pubmed]
  8. Mannose-specific isolectins with different hemagglutinating potencies isolated from Chinese daffodil (Narcissus tazetta var. chinensis) leaves. Ooi, L.S., Ng, T.B., Sun, S.S., Ooi, V.E. J. Protein Chem. (2000) [Pubmed]
  9. The mannose-specific bulb lectin from Galanthus nivalis (snowdrop) binds mono- and dimannosides at distinct sites. Structure analysis of refined complexes at 2.3 A and 3.0 A resolution. Hester, G., Wright, C.S. J. Mol. Biol. (1996) [Pubmed]
  10. Genetic analysis of male reproductive contributions in Chamaelirium luteum (L.) gray (Liliaceae). Smouse, P.E., Meagher, T.R. Genetics (1994) [Pubmed]
  11. Lycobetaine acts as a selective topoisomerase II beta poison and inhibits the growth of human tumour cells. Barthelmes, H.U., Niederberger, E., Roth, T., Schulte, K., Tang, W.C., Boege, F., Fiebig, H.H., Eisenbrand, G., Marko, D. Br. J. Cancer (2001) [Pubmed]
  12. Total synthesis of Amaryllidaceae alkaloids utilizing sequential intramolecular heterocyclic azadiene Diels-Alder reactions of an unsymmetrical 1,2,4,5-tetrazine. Boger, D.L., Wolkenberg, S.E. J. Org. Chem. (2000) [Pubmed]
  13. Inhibition of [3H]citalopram binding to the rat brain serotonin transporter by Amaryllidaceae alkaloids. Elgorashi, E.E., Stafford, G.I., Jäger, A.K., van Staden, J. Planta Med. (2006) [Pubmed]
  14. Primary transcripts of ndhD of Liliaceae and Aloaceae require editing of the start and 20th codons. López-Serrano, M., Del Campo, E.M., Sabater, B., Martín, M. J. Exp. Bot. (2001) [Pubmed]
  15. Chronotropic effect of the methanolic extracts of the plants of the Paris species and steroidal glycosides isolated from P. vietnamensis on spontaneous beating of myocardial cells. Nambu, T., Huang, X., Shu, Y., Huang, S., Hattori, M., Kakiuchi, N., Wang, Q., Xu, G.J. Planta Med. (1989) [Pubmed]
  16. The development and evaluation of consensus chloroplast primer pairs that possess highly variable sequence regions in a diverse array of plant taxa. Chung, S.M., Staub, J.E. Theor. Appl. Genet. (2003) [Pubmed]
  17. Phytochemical investigation of Hippeastrum vittatum growing in Egypt. Part II. Isolation and identification of new alkaloids. el Mohgazi, A.M., Ali, A.A., Mesbah, M.K. Planta Med. (1975) [Pubmed]
  18. Antiplasmodial and antioxidant isofuranonaphthoquinones from the roots of Bulbine capitata. Bezabih, M., Abegaz, B.M., Dufall, K., Croft, K., Skinner-Adams, T., Davis, T.M. Planta Med. (2001) [Pubmed]
  19. Molecular cloning of mannose-binding lectins from Clivia miniata. Van Damme, E.J., Smeets, K., Van Leuven, F., Peumans, W.J. Plant Mol. Biol. (1994) [Pubmed]
  20. Antioxidative activity of Allium victorialis L. extracts. Shirataki, Y., Motohashi, N., Tani, S., Sunaga, K., Sakagami, H., Satoh, K., Nakashima, H., Kanamoto, T., Wolfard, K., Molnar, J. Anticancer Res. (2001) [Pubmed]
  21. A monomeric mannose-binding lectin from inner shoots of the edible chive (Allium tuberosum). Lam, Y.W., Ng, T.B. J. Protein Chem. (2001) [Pubmed]
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