Disease relevance of RPL23

• Ribosomal proteins (RP) S13 and RPL23 were previously identified as two upregulated genes in a multidrug-resistant gastric cancer cell line SGC7901/VCR compared to its parental cell SGC7901 by differential display PCR [1].
• RESULTS: Two immunodominant proteins of Yersinia enterocolitica were found, one being the urease beta-subunit and the other the 50 S ribosomal protein L23 [2].
• The evolutionarily conserved ribosomal protein L23 and the cationic urease beta-subunit of Yersinia enterocolitica O:3 belong to the immunodominant antigens in Yersinia-triggered reactive arthritis: implications for autoimmunity [2].

High impact information on RPL23

• Using an immunoaffinity method, we purified an MDM2-associated protein complex that contains the ribosomal protein L23 [3].
• A conserved motif is prerequisite for the interaction of NAC with ribosomal protein L23 and nascent chains [4].
• cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17 [5].
• The rpl23 gene identified in tobacco and Marchantia, is split into two overlapping reading frames in spinach [6].
• RPS13 and RPL23 were genetically overexpressed in SGC7901 cells, respectively [1].

Biological context of RPL23

• However, either RPS13 or RPL23 could protect SGC7901 cells from undergoing vincristine-induced apoptosis [1].
• Phylogenetic analysis of the deduced amino acid sequences demonstrated that each of the T. ruralis proteins is most similar to ribosomal proteins from higher plants even though RPS14 and RPL23 show high divergence from their other plant counterparts [7].
• This intergenic spacer contains a pseudogene for rpl23 as well as two noncoding segments with different A+T contents [8].

Associations of RPL23 with chemical compounds

• Either RPS13 or RPL23 enhanced resistance of SGC7901 cells to vincristine, adriamycin, and 5-fludrouracil [1].
• RPL23 also enhanced resistance of SGC7901 cells to cisplatin [1].
• In addition, overexpression of RPL23 enhanced glutathione S-transferase (GST) activity and intracellular glutathione content in SGC7901 cells [1].

Physical interactions of RPL23

• Here we show that the ribosomal protein L23 interacts with HDM2 [9].

Other interactions of RPL23

• The translational apparatus of Tortula ruralis: polysomal retention of transcripts encoding the ribosomal proteins RPS14, RPS16 and RPL23 in desiccated and rehydrated gametophytes [7].
• The clone contains the genes for ribosomal protein S4, RNA polymerase subunit alpha and ribosomal protein L17 in this order [10].
• Northern analysis revealed increases in the levels of clpP, rpl2, rpl23, rps15 and rpoB mRNAs in total RNA from albino leaves relative to those in green leaves [11].

Analytical, diagnostic and therapeutic context of RPL23

• Western blot analysis revealed that both RPS13 and RPL23 significantly increased the expression level of Bcl-2 and Bcl-2/Bax ratio in SGC7901 cells [1].

References