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Gene Review

RPL23  -  ribosomal protein L23

Homo sapiens

Synonyms: 60S ribosomal protein L17, 60S ribosomal protein L23, L23, rpL17
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Disease relevance of RPL23


High impact information on RPL23


Biological context of RPL23

  • However, either RPS13 or RPL23 could protect SGC7901 cells from undergoing vincristine-induced apoptosis [1].
  • Phylogenetic analysis of the deduced amino acid sequences demonstrated that each of the T. ruralis proteins is most similar to ribosomal proteins from higher plants even though RPS14 and RPL23 show high divergence from their other plant counterparts [7].
  • This intergenic spacer contains a pseudogene for rpl23 as well as two noncoding segments with different A+T contents [8].

Associations of RPL23 with chemical compounds

  • Either RPS13 or RPL23 enhanced resistance of SGC7901 cells to vincristine, adriamycin, and 5-fludrouracil [1].
  • RPL23 also enhanced resistance of SGC7901 cells to cisplatin [1].
  • In addition, overexpression of RPL23 enhanced glutathione S-transferase (GST) activity and intracellular glutathione content in SGC7901 cells [1].

Physical interactions of RPL23


Other interactions of RPL23

  • The translational apparatus of Tortula ruralis: polysomal retention of transcripts encoding the ribosomal proteins RPS14, RPS16 and RPL23 in desiccated and rehydrated gametophytes [7].
  • The clone contains the genes for ribosomal protein S4, RNA polymerase subunit alpha and ribosomal protein L17 in this order [10].
  • Northern analysis revealed increases in the levels of clpP, rpl2, rpl23, rps15 and rpoB mRNAs in total RNA from albino leaves relative to those in green leaves [11].

Analytical, diagnostic and therapeutic context of RPL23

  • Western blot analysis revealed that both RPS13 and RPL23 significantly increased the expression level of Bcl-2 and Bcl-2/Bax ratio in SGC7901 cells [1].


  1. Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis. Shi, Y., Zhai, H., Wang, X., Han, Z., Liu, C., Lan, M., Du, J., Guo, C., Zhang, Y., Wu, K., Fan, D. Exp. Cell Res. (2004) [Pubmed]
  2. The evolutionarily conserved ribosomal protein L23 and the cationic urease beta-subunit of Yersinia enterocolitica O:3 belong to the immunodominant antigens in Yersinia-triggered reactive arthritis: implications for autoimmunity. Mertz, A.K., Daser, A., Skurnik, M., Wiesmüller, K.H., Braun, J., Appel, H., Batsford, S., Wu, P., Distler, A., Sieper, J. Mol. Med. (1994) [Pubmed]
  3. Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Dai, M.S., Zeng, S.X., Jin, Y., Sun, X.X., David, L., Lu, H. Mol. Cell. Biol. (2004) [Pubmed]
  4. A conserved motif is prerequisite for the interaction of NAC with ribosomal protein L23 and nascent chains. Wegrzyn, R.D., Hofmann, D., Merz, F., Nikolay, R., Rauch, T., Graf, C., Deuerling, E. J. Biol. Chem. (2006) [Pubmed]
  5. cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17. Hérault, Y., Michel, D., Chatelain, G., Brun, G. Nucleic Acids Res. (1991) [Pubmed]
  6. Expression of the rpl23, rpl2 and rps19 genes in spinach chloroplasts. Thomas, F., Massenet, O., Dorne, A.M., Briat, J.F., Mache, R. Nucleic Acids Res. (1988) [Pubmed]
  7. The translational apparatus of Tortula ruralis: polysomal retention of transcripts encoding the ribosomal proteins RPS14, RPS16 and RPL23 in desiccated and rehydrated gametophytes. Wood, A.J., Joel Duff, R., Oliver, M.J. J. Exp. Bot. (2000) [Pubmed]
  8. Neighboring base composition is strongly correlated with base substitution bias in a region of the chloroplast genome. Morton, B.R., Clegg, M.T. J. Mol. Evol. (1995) [Pubmed]
  9. Inhibition of HDM2 and activation of p53 by ribosomal protein L23. Jin, A., Itahana, K., O'Keefe, K., Zhang, Y. Mol. Cell. Biol. (2004) [Pubmed]
  10. Molecular cloning of the gene encoding RNA polymerase alpha subunit from deep-sea barophilic bacterium. Nakasone, K., Kato, C., Horikoshi, K. Biochim. Biophys. Acta (1996) [Pubmed]
  11. Differential regulation of genes transcribed by nucleus-encoded plastid RNA polymerase, and DNA amplification, within ribosome-deficient plastids in stable phenocopies of cereal albino mutants. Zubko, M.K., Day, A. Mol. Genet. Genomics (2002) [Pubmed]
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