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Gene Review:

SEC14L1 - SEC14-like 1 (S. cerevisiae)

Homo sapiens

Synonyms: PRELID4A, SEC14-like protein 1, SEC14L

Kalikin, L.M. et al., Ribeiro, F.M. et al., Welti, S. et al., Neuzil, J. et al., Chinen, K. et al., et al.

Neuzil, Dong, Wang, Zingg,

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Disease relevance of SEC14L1

As retinoids have been shown to inhibit the growth of breast cancer cells, loss of the proposed SEC14L1 retinal-binding function may contribute to breast tumorigenesis [1].
We studied the role of the ubiquitous tocopherol-associated protein-1 (TAP1 or sec14-like 2) in apoptosis induction by alpha-TOS in malignant mesothelioma (MM) cells [2].

High impact information on SEC14L1

Using lipid exchange assays along with mass spectrometry we show here that the Sec14-like portion binds to 1-(3-sn-phosphatidyl)-sn-glycerol (PtdGro), (3-sn-phosphatidyl)-ethanolamine (PtdEtn) and -choline (PtdCho) and to a minor extent to (3-sn-phosphatidyl)-l-serine (PtdSer) and 1-(3-sn-phosphatidyl)-d-myo-inositol (PtdIns) [3].
In contrast, overexpression of VAChT or CHT1 with SEC14L1 recruited the latter to large intracellular organelles similar to vesicles or vesicle aggregates [4].
In cultured cells SEC14L1 was predominantly found in the cytosol with little or no localization in defined organelles [4].
Finally, we find that overexpression of SEC14L1 modestly decreases high affinity choline transport activity [4].
In addition, we have characterised and localised a putative pseudogene of the SEC14-like 1 gene [5].

Biological context of SEC14L1

We more precisely mapped SEC14L1 within a discrete region of 17q25 that likely harbors at least one putative breast and ovarian tumor suppressor gene [1].
Human SEC14L1 shows partial sequence homology to the budding yeast SEC14 protein and the Japanese flying squid retinal-binding protein and was previously generally localized to 17q25 [1].
SEC14L, which was expressed in all human tissues examined, was localized to chromosome bands 17q25.1 --> q25.2 by fluorescence in situ hybridization [6].

Anatomical context of SEC14L1

EST H49244 spanned exon 11 of SEC14L1 and was specifically expressed in human peripheral blood leukocytes [1].

Other interactions of SEC14L1

Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP [7].

References

Genomic characterization of human SEC14L1 splice variants within a 17q25 candidate tumor suppressor gene region and identification of an unrelated embedded expressed sequence tag. Kalikin, L.M., Bugeaud, E.M., Palmbos, P.L., Lyons, R.H., Petty, E.M. Mamm. Genome (2001) [Pubmed]
Tocopherol-associated protein-1 accelerates apoptosis induced by alpha-tocopheryl succinate in mesothelioma cells. Neuzil, J., Dong, L.F., Wang, X.F., Zingg, J.M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
The sec14 homology module of neurofibromin binds cellular glycerophospholipids: mass spectrometry and structure of a lipid complex. Welti, S., Fraterman, S., D'Angelo, I., Wilm, M., Scheffzek, K. J. Mol. Biol. (2007) [Pubmed]
SEC14-like protein 1 interacts with cholinergic transporters. Ribeiro, F.M., Ferreira, L.T., Marion, S., Fontes, S., Gomez, M., Ferguson, S.S., Prado, M.A., Prado, V.F. Neurochem. Int. (2007) [Pubmed]
Mutation analysis of 4 candidate genes for hereditary neuralgic amyotrophy (HNA). Meuleman, J., Kuhlenbäumer, G., Audenaert, D., Hünermund, G., Hor, H., Young, P., Stögbauer, F., Ringelstein, E.B., Van Broeckhoven, C., De Jonghe, P., Timmerman, V. Hum. Genet. (2001) [Pubmed]
Isolation and mapping of a human gene (SEC14L), partially homologous to yeast SEC14, that contains a variable number of tandem repeats (VNTR) site in its 3' untranslated region. Chinen, K., Takahashi, E., Nakamura, Y. Cytogenet. Cell Genet. (1996) [Pubmed]
Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP. Ye, X., Ji, C., Yin, G., Tang, R., Zeng, L., Gu, S., Ying, K., Xie, Y., Zhao, R.C., Mao, Y. Mol. Biol. Rep. (2004) [Pubmed]

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