The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GAL3ST2  -  galactose-3-O-sulfotransferase 2

Homo sapiens

Synonyms: Beta-galactose-3-O-sulfotransferase 2, GAL3ST-2, GP3ST, Gal-beta-1, 3-GalNAc 3'-sulfotransferase 2, Gal3ST-2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of GAL3ST2


High impact information on GAL3ST2

  • Mg(2+), Mn(2+), and Ca(2+) stimulated the activities of Gal3ST-2, whereas only Mg(2+) augmented Gal3ST-3 activity [3].
  • Kinetics studies suggested that GP3ST is able to act on both type 1 (Gal beta 1-3GlcNAc-R) and type 2 (Gal beta 1-4GlcNAc-R) chains with a similar efficiency [4].
  • Therefore, the substrate specificity was different from that of GP3ST [5].
  • The amino acid sequence showed 33% identity with that of human CST and 38% with that of human GP3ST [5].
  • The 3'-sulfolacto-N-fucopentaose III (sulfo-3Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galbeta1-4Glc)-PA was then synthesized from lacto-N-neotetraose (Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc)-PA by GP3ST and FucT-III, -IV, -V, -VI, -VII, or -IX in a similar manner [6].

Biological context of GAL3ST2


Anatomical context of GAL3ST2


Associations of GAL3ST2 with chemical compounds

  • Moreover, Gal3ST-3 but not Gal3ST-2 can act on Galbeta1-->4(sulfo-->6)GlcNAc, indicating that disulfated sulfo-->3Galbeta1-->4(sulfo-->6) GlcNAc-->R may be formed by Gal3ST-3 in combination with GlcNAc 6-O-sulfotransferase [7].
  • Membrane-bound beta-Gal-3'-sulfotransferase (GP3ST) was expressed and used for in vitro sulfation of Tamm-Horsfall glycoprotein [8].
  • Further, the regioselective transfer of sulfate to an N-acetyllactosamine derivative could be realised with soluble chimeric GP3ST, also in combination with Lac transglycosylation by means of beta-galactosidase [8].


  1. Gal3ST-2 involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrins. Shi, B.Z., Hu, P., Geng, F., He, P.J., Wu, X.Z. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  2. Down-regulation of Gal 3-O-sulfotransferase-2 (Gal3ST-2) expression in human colonic non-mucinous adenocarcinoma. Seko, A., Nagata, K., Yonezawa, S., Yamashita, K. Jpn. J. Cancer Res. (2002) [Pubmed]
  3. Identification of physiologically relevant substrates for cloned Gal: 3-O-sulfotransferases (Gal3STs): distinct high affinity of Gal3ST-2 and LS180 sulfotransferase for the globo H backbone, Gal3ST-3 for N-glycan multiterminal Galbeta1, 4GlcNAcbeta units and 6-sulfoGalbeta1, 4GlcNAcbeta, and Gal3ST-4 for the mucin core-2 trisaccharide. Chandrasekaran, E.V., Lakhaman, S.S., Chawda, R., Piskorz, C.F., Neelamegham, S., Matta, K.L. J. Biol. Chem. (2004) [Pubmed]
  4. Molecular cloning and characterization of a human beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2 (Gal beta 1-3/1-4GlcNAc-R) oligosaccharides. Honke, K., Tsuda, M., Koyota, S., Wada, Y., Iida-Tanaka, N., Ishizuka, I., Nakayama, J., Taniguchi, N. J. Biol. Chem. (2001) [Pubmed]
  5. A novel human Gal-3-O-sulfotransferase: molecular cloning, characterization, and its implications in biosynthesis of (SO(4)-3)Galbeta1-4(Fucalpha1-3)GlcNAc. El-Fasakhany, F.M., Uchimura, K., Kannagi, R., Muramatsu, T. J. Biol. Chem. (2001) [Pubmed]
  6. A remodeling system of the 3'-sulfo-Lewis a and 3'-sulfo-Lewis x epitopes. Ikeda, N., Eguchi, H., Nishihara, S., Narimatsu, H., Kannagi, R., Irimura, T., Ohta, M., Matsuda, H., Taniguchi, N., Honke, K. J. Biol. Chem. (2001) [Pubmed]
  7. Molecular cloning and expression of a novel human beta-Gal-3-O-sulfotransferase that acts preferentially on N-acetyllactosamine in N- and O-glycans. Suzuki, A., Hiraoka, N., Suzuki, M., Angata, K., Misra, A.K., McAuliffe, J., Hindsgaul, O., Fukuda, M. J. Biol. Chem. (2001) [Pubmed]
  8. In vitro sulfation of N-acetyllactosaminide by soluble recombinant human beta-Gal-3'-sulfotransferase. Greimel, P., Jabs, S., Storch, S., Cherif, S., Honke, K., Braulke, T., Thiem, J. Carbohydr. Res. (2006) [Pubmed]
WikiGenes - Universities