High impact information on CRLF2

• We show here that TSLP expression was increased in the lungs of mice with antigen-induced asthma, whereas TSLP receptor-deficient mice had considerably attenuated disease [1].
• Human TSLPR and IL-7Ralpha are principally coexpressed on monocytes and dendritic cell populations and to a much lesser extent on various lymphoid cells [2].
• Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes [3].
• Northern blot analysis showed that CRL2 was restrictedly expressed by spleen and peripheral blood leukocytes, and abundantly expressed by HL-60 cells [3].
• From a human dendritic cell (DC) cDNA library, we identified a novel type I cytokine receptor, designated as cytokine receptor-like molecule 2 (CRL2) [3].

Biological context of CRLF2

• Our data demonstrate that TSLP-mediated Stat5 activation is insufficient for cell proliferation and identifies residues within the TSLP receptor complex required to mediate these downstream events [4].

Anatomical context of CRLF2

• Northern blot analysis revealed CRLF2 mRNA in liver, kidney, heart, and skeletal muscle [5].
• In humans, TSLP is produced predominantly by epithelial cells and activated mast cells, and stimulates myeloid dendritic cells (mDC), which uniquely express the heterodimeric TSLP receptor [6].

Other interactions of CRLF2

• The gene for CRLF2 was mapped to the pseudoautosomal region, Xp22.3 and Yp11.3 by FISH analysis, a region where genes encoding the IL-3 receptor alpha and the GM-CSF receptor alpha chains are also located [5].

Analytical, diagnostic and therapeutic context of CRLF2

• Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR [5].
• RT-PCR analysis demonstrated that CRL2 was preferentially expressed by DC and monocytes [3].

References