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Gene Review

CRLF2  -  cytokine receptor-like factor 2

Homo sapiens

Synonyms: CRL2, CRLF2Y, Cytokine receptor-like 2, Cytokine receptor-like factor 2, IL-XR, ...
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High impact information on CRLF2


Biological context of CRLF2

  • Our data demonstrate that TSLP-mediated Stat5 activation is insufficient for cell proliferation and identifies residues within the TSLP receptor complex required to mediate these downstream events [4].

Anatomical context of CRLF2


Other interactions of CRLF2


Analytical, diagnostic and therapeutic context of CRLF2


  1. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Zhou, B., Comeau, M.R., De Smedt, T., Liggitt, H.D., Dahl, M.E., Lewis, D.B., Gyarmati, D., Aye, T., Campbell, D.J., Ziegler, S.F. Nat. Immunol. (2005) [Pubmed]
  2. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. Reche, P.A., Soumelis, V., Gorman, D.M., Clifford, T., Liu Mr, n.u.l.l., Travis, M., Zurawski, S.M., Johnston, J., Liu, Y.J., Spits, H., de Waal Malefyt, R., Kastelein, R.A., Bazan, J.F. J. Immunol. (2001) [Pubmed]
  3. Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes. Zhang, W., Wang, J., Wang, Q., Chen, G., Zhang, J., Chen, T., Wan, T., Zhang, Y., Cao, X. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  4. Uncoupling of proliferation and Stat5 activation in thymic stromal lymphopoietin-mediated signal transduction. Isaksen, D.E., Baumann, H., Zhou, B., Nivollet, S., Farr, A.G., Levin, S.D., Ziegler, S.F. J. Immunol. (2002) [Pubmed]
  5. Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR. Tonozuka, Y., Fujio, K., Sugiyama, T., Nosaka, T., Hirai, M., Kitamura, T. Cytogenet. Cell Genet. (2001) [Pubmed]
  6. Thymic stromal lymphopoietin:a potential therapeutic target for allergy and asthma. Huston, D.P., Liu, Y.J. Current allergy and asthma reports. (2006) [Pubmed]
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