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Gene Review

Csf2ra  -  colony stimulating factor 2 receptor,...

Mus musculus

Synonyms: CD116, Csfgmra, GM-CSF-R-alpha, GM-CSF-Ra, GM-CSFR, ...
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Disease relevance of Csf2ra


High impact information on Csf2ra

  • Our data indicate that activation of the GM-CSF receptor induces differentiation of stem cells by an instructive mechanism that can be blocked by the activated IL-3 receptor [5].
  • Chimaeric IL-2 receptor beta and gamma chains constructed with the heterodimeric extracellular regions of the granulocyte-macrophage colony stimulating factor receptor (GM-CSFR) also provided the IL-2R signal [6].
  • Engagement of IL3-R and GM-CSF-R in these cells leads to increased and prolonged PI3'K-dependent PI(3,4,5)P3 accumulation and PKB activation [7].
  • However, mice in which the genes encoding GM-CSF (Gmcsf) or the beta common subunit of the GM-CSF receptor (betac) are inactivated display normal steady-state hematopoiesis [8].
  • GM-CSF receptor immunoreactivity was found on neurons within the paraventricular and arcuate nuclei of the hypothalamus [9].

Chemical compound and disease context of Csf2ra

  • Analysis of various mutants of the cytoplasmic region of GM-CSFR indicated that both the conserved membrane proximal region and tyrosine residues located in the distal part of the beta subunit were required for HIV-1 LTR activation [10].

Biological context of Csf2ra


Anatomical context of Csf2ra


Associations of Csf2ra with chemical compounds


Physical interactions of Csf2ra


Regulatory relationships of Csf2ra


Other interactions of Csf2ra

  • These results indicate that the beta subunit of the GM-CSF receptor is required for generation of growth signals and that AIC2B is likely the beta subunit of the mouse GM-CSF receptor [23].
  • This technology has been applied to the study of interactions between human granulocyte-macrophage colony-stimulating factor (GM-CSF) and its receptor (GM-CSFR) [24].
  • Regulation of IL-5R alpha, IL-3R alpha and GM-CSFR alpha expression in the developmental stage appears to be important for understanding the unique function of these cytokines on a particular cell type [25].
  • Developmental expression of Magmas in murine tissues and its co-expression with the GM-CSF receptor [26].
  • A maximum reduction in GM-CSF receptor numbers of 65% to 77% was observed by 96-hour incubation with TGF-beta [27].

Analytical, diagnostic and therapeutic context of Csf2ra


  1. Defective expression of granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 receptor common beta chain in children with acute myeloid leukemia associated with respiratory failure. Dirksen, U., Hattenhorst, U., Schneider, P., Schroten, H., Göbel, U., Böcking, A., Müller, K.M., Murray, R., Burdach, S. Blood (1998) [Pubmed]
  2. Characterization of the cell surface receptor for human granulocyte/macrophage colony-stimulating factor. Park, L.S., Friend, D., Gillis, S., Urdal, D.L. J. Exp. Med. (1986) [Pubmed]
  3. In vivo targeting of leukemic cells using diphtheria toxin fused to murine GM-CSF. Rozemuller, H., Rombouts, E.J., Touw, I.P., FitzGerald, D.J., Kreitman, R.J., Hagenbeek, A., Martens, A.C. Leukemia (1998) [Pubmed]
  4. Growth stimulation of non-small cell lung cancer xenografts by granulocyte-macrophage colony-stimulating factor (GM-CSF). Oshika, Y., Nakamura, M., Abe, Y., Fukuchi, Y., Yoshimura, M., Itoh, M., Ohnishi, Y., Tokunaga, T., Fukushima, Y., Hatanaka, H., Kijima, H., Yamazaki, H., Tamaoki, N., Ueyama, Y. Eur. J. Cancer (1998) [Pubmed]
  5. Expression of the GM-CSF gene after retroviral transfer in hematopoietic stem cell lines induces synchronous granulocyte-macrophage differentiation. Just, U., Stocking, C., Spooncer, E., Dexter, T.M., Ostertag, W. Cell (1991) [Pubmed]
  6. Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation. Nelson, B.H., Lord, J.D., Greenberg, P.D. Nature (1994) [Pubmed]
  7. SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Liu, Q., Sasaki, T., Kozieradzki, I., Wakeham, A., Itie, A., Dumont, D.J., Penninger, J.M. Genes Dev. (1999) [Pubmed]
  8. Granulocyte/macrophage colony-stimulating factor and accessory cells modulate radioprotection by purified hematopoietic cells. Katsumoto, T.R., Duda, J., Kim, A., Wardak, Z., Dranoff, G., Clapp, D.W., Shannon, K. J. Exp. Med. (2005) [Pubmed]
  9. GM-CSF action in the CNS decreases food intake and body weight. Reed, J.A., Clegg, D.J., Smith, K.B., Tolod-Richer, E.G., Matter, E.K., Picard, L.S., Seeley, R.J. J. Clin. Invest. (2005) [Pubmed]
  10. Human GM-CSF induces HIV-1 LTR by multiple signalling pathways. Watanabe, S., Murakami, T., Nakamura, T., Morimoto, C., Arai, K. Biochimie (2002) [Pubmed]
  11. A human GM-CSF receptor expressed in transgenic mice stimulates proliferation and differentiation of hemopoietic progenitors to all lineages in response to human GM-CSF. Nishijima, I., Nakahata, T., Hirabayashi, Y., Inoue, T., Kurata, H., Miyajima, A., Hayashi, N., Iwakura, Y., Arai, K., Yokota, T. Mol. Biol. Cell (1995) [Pubmed]
  12. Differential regulation of early response genes and cell proliferation through the human granulocyte macrophage colony-stimulating factor receptor: selective activation of the c-fos promoter by genistein. Watanabe, S., Muto, A., Yokota, T., Miyajima, A., Arai, K. Mol. Biol. Cell (1993) [Pubmed]
  13. Effect of granulocyte-macrophage colony-stimulating factor deficiency on ovarian follicular cell function. Gilchrist, R.B., Rowe, D.B., Ritter, L.J., Robertson, S.A., Norman, R.J., Armstrong, D.T. J. Reprod. Fertil. (2000) [Pubmed]
  14. Zidovudine (AZT) treatment suppresses granulocyte-monocyte colony stimulating factor receptor type alpha (GM-CSFR alpha) gene expression in murine bone marrow cells. Chitnis, S., Mondal, D., Agrawal, K.C. Life Sci. (2002) [Pubmed]
  15. Autosomal telomere exchange results in the rapid amplification and dispersion of Csf2ra genes in wild-derived mice. Brannan, C.I., Disteche, C.M., Park, L.S., Copeland, N.G., Jenkins, N.A. Mamm. Genome (2001) [Pubmed]
  16. Cytoplasmic domains of the leukemia inhibitory factor receptor required for STAT3 activation, differentiation, and growth arrest of myeloid leukemic cells. Tomida, M., Heike, T., Yokota, T. Blood (1999) [Pubmed]
  17. Functional cross-talk between cytokine receptors revealed by activating mutations in the extracellular domain of the beta-subunit of the GM-CSF receptor. Blake, T.J., Jenkins, B.J., D'Andrea, R.J., Gonda, T.J. J. Leukoc. Biol. (2002) [Pubmed]
  18. Granulocyte-macrophage colony-stimulating factor (GM-CSF) targets myeloid leukocytes in the uterus during the post-mating inflammatory response in mice. Robertson, S.A., O'Connell, A.C., Hudson, S.N., Seamark, R.F. J. Reprod. Immunol. (2000) [Pubmed]
  19. Granulocyte-macrophage colony-stimulating factor promotes glucose transport and blastomere viability in murine preimplantation embryos. Robertson, S.A., Sjöblom, C., Jasper, M.J., Norman, R.J., Seamark, R.F. Biol. Reprod. (2001) [Pubmed]
  20. Purified murine granulocyte/macrophage progenitor cells express a high-affinity receptor for recombinant murine granulocyte/macrophage colony-stimulating factor. Williams, D.E., Bicknell, D.C., Park, L.S., Straneva, J.E., Cooper, S., Broxmeyer, H.E. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  21. Cytoplasmic domains of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor beta chain (hbetac) responsible for human GM-CSF-induced myeloid cell differentiation. Matsuguchi, T., Lilly, M.B., Kraft, A.S. J. Biol. Chem. (1998) [Pubmed]
  22. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and inflammatory stimuli up-regulate secretion of the soluble GM-CSF receptor in human monocytes: evidence for ectodomain shedding of the cell surface GM-CSF receptor alpha subunit. Prevost, J.M., Pelley, J.L., Zhu, W., D'Egidio, G.E., Beaudry, P.P., Pihl, C., Neely, G.G., Claret, E., Wijdenes, J., Brown, C.B. J. Immunol. (2002) [Pubmed]
  23. Reconstitution of functional receptors for human granulocyte/macrophage colony-stimulating factor (GM-CSF): evidence that the protein encoded by the AIC2B cDNA is a subunit of the murine GM-CSF receptor. Kitamura, T., Hayashida, K., Sakamaki, K., Yokota, T., Arai, K., Miyajima, A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  24. Granulocyte-macrophage colony-stimulating factor mimicry and receptor interactions. Von Feldt, J.M., Monfardini, C., Kieber-Emmons, T., Voet, D., Weiner, D.B., Williams, W.V. Immunol. Res. (1994) [Pubmed]
  25. Interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) can induce differentiation of chronic B cell leukemia expressing the alpha subunit of IL-3 and GM-CSF receptor. Shiiba, M., Takaki, S., Takatsu, K. Int. Arch. Allergy Immunol. (1996) [Pubmed]
  26. Developmental expression of Magmas in murine tissues and its co-expression with the GM-CSF receptor. Jubinsky, P.T., Short, M.K., Mutema, G., Witte, D.P. J. Histochem. Cytochem. (2003) [Pubmed]
  27. Transforming growth factor-beta trans-modulates the expression of colony stimulating factor receptors on murine hematopoietic progenitor cell lines. Jacobsen, S.E., Ruscetti, F.W., Dubois, C.M., Lee, J., Boone, T.C., Keller, J.R. Blood (1991) [Pubmed]
  28. Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750. Inhorn, R.C., Carlesso, N., Durstin, M., Frank, D.A., Griffin, J.D. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  29. Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. Hayashida, K., Kitamura, T., Gorman, D.M., Arai, K., Yokota, T., Miyajima, A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
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