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Gene Review

TSLP  -  thymic stromal lymphopoietin

Homo sapiens

Synonyms: Thymic stromal lymphopoietin
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Disease relevance of TSLP


High impact information on TSLP


Biological context of TSLP


Anatomical context of TSLP


Associations of TSLP with chemical compounds

  • In addition, TSLP shares many biological properties with the related cytokine IL-7 [9].
  • The combination of TNF-alpha and IL-4 produced detectable levels of TSLP protein (40 +/- 13 pg/ml) [13].

Physical interactions of TSLP

  • Human TSLP is proposed to signal through a heterodimeric receptor complex that consists of a new member of the hemopoietin family termed human TSLP receptor and the IL-7R alpha-chain [10].

Enzymatic interactions of TSLP

  • Because Stat5 phosphorylation following cytokine stimulation is generally mediated by Jaks, the lack of Jak activation after TSLP treatment suggested the possibility that tyrosine-phosphorylated Stat5 may be nonfunctional [9].

Regulatory relationships of TSLP


Other interactions of TSLP

  • Moreover, TSLP-mediated signaling is inhibited by suppressor of cytokine signaling (SOCS)-1 and a kinase-deficient version of Tec but not by kinase-deficient forms of Jak1 and Jak2 [9].
  • Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells [11].
  • Here, we show that TSLP-activated CD11c+ DCs potently activate and expand naive CD8+ T cells, and induce their differentiation into interleukin (IL)-5 and IL-13-producing effectors exhibiting poor cytolytic activity [11].
  • Epithelial human TSLP activates DC, which allow them to prime naive T cells for the production of pro-inflammatory cytokines, while down-regulating IFN-gamma and IL-10 [17].
  • Gene expression profiles screened a variety of molecules that are triggered by TSLP with or without CD40 ligation [18].

Analytical, diagnostic and therapeutic context of TSLP


  1. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Soumelis, V., Reche, P.A., Kanzler, H., Yuan, W., Edward, G., Homey, B., Gilliet, M., Ho, S., Antonenko, S., Lauerma, A., Smith, K., Gorman, D., Zurawski, S., Abrams, J., Menon, S., McClanahan, T., de Waal-Malefyt Rd, R., Bazan, F., Kastelein, R.A., Liu, Y.J. Nat. Immunol. (2002) [Pubmed]
  2. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. Ying, S., O'Connor, B., Ratoff, J., Meng, Q., Mallett, K., Cousins, D., Robinson, D., Zhang, G., Zhao, J., Lee, T.H., Corrigan, C. J. Immunol. (2005) [Pubmed]
  3. Growth factor expression in a murine model of cryoglobulinemia. Taneda, S., Hudkins, K.L., Cui, Y., Farr, A.G., Alpers, C.E., Segerer, S. Kidney Int. (2003) [Pubmed]
  4. Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation. Liu, Y.J. J. Allergy Clin. Immunol. (2007) [Pubmed]
  5. Tweaking of memory T helper 2 cells by TSLP. Kapsenberg, M. Immunity (2006) [Pubmed]
  6. Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells. Wang, Y.H., Ito, T., Wang, Y.H., Homey, B., Watanabe, N., Martin, R., Barnes, C.J., McIntyre, B.W., Gilliet, M., Kumar, R., Yao, Z., Liu, Y.J. Immunity (2006) [Pubmed]
  7. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Zhou, B., Comeau, M.R., De Smedt, T., Liggitt, H.D., Dahl, M.E., Lewis, D.B., Gyarmati, D., Aye, T., Campbell, D.J., Ziegler, S.F. Nat. Immunol. (2005) [Pubmed]
  8. Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion. Watanabe, N., Hanabuchi, S., Soumelis, V., Yuan, W., Ho, S., de Waal Malefyt, R., Liu, Y.J. Nat. Immunol. (2004) [Pubmed]
  9. Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction. Isaksen, D.E., Baumann, H., Trobridge, P.A., Farr, A.G., Levin, S.D., Ziegler, S.F. J. Immunol. (1999) [Pubmed]
  10. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. Reche, P.A., Soumelis, V., Gorman, D.M., Clifford, T., Liu Mr, n.u.l.l., Travis, M., Zurawski, S.M., Johnston, J., Liu, Y.J., Spits, H., de Waal Malefyt, R., Kastelein, R.A., Bazan, J.F. J. Immunol. (2001) [Pubmed]
  11. Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells. Gilliet, M., Soumelis, V., Watanabe, N., Hanabuchi, S., Antonenko, S., de Waal-Malefyt, R., Liu, Y.J. J. Exp. Med. (2003) [Pubmed]
  12. Uncoupling of proliferation and Stat5 activation in thymic stromal lymphopoietin-mediated signal transduction. Isaksen, D.E., Baumann, H., Zhou, B., Nivollet, S., Farr, A.G., Levin, S.D., Ziegler, S.F. J. Immunol. (2002) [Pubmed]
  13. TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. Kato, A., Favoreto, S., Avila, P.C., Schleimer, R.P. J. Immunol. (2007) [Pubmed]
  14. Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin. Pandey, A., Ozaki, K., Baumann, H., Levin, S.D., Puel, A., Farr, A.G., Ziegler, S.F., Leonard, W.J., Lodish, H.F. Nat. Immunol. (2000) [Pubmed]
  15. Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential. Watanabe, N., Hanabuchi, S., Marloie-Provost, M.A., Antonenko, S., Liu, Y.J., Soumelis, V. Blood (2005) [Pubmed]
  16. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. Ito, T., Wang, Y.H., Duramad, O., Hori, T., Delespesse, G.J., Watanabe, N., Qin, F.X., Yao, Z., Cao, W., Liu, Y.J. J. Exp. Med. (2005) [Pubmed]
  17. Interactions between dendritic cells and epithelial cells in allergic disease. Roggen, E.L., Lindstedt, M., Borrebaeck, C., Verheyen, G.R. Toxicol. Lett. (2006) [Pubmed]
  18. Gene expression profiles of peripheral and cord blood mononuclear cells altered by thymic stromal lymphopoietin. Urashima, M., Sakuma, M., Teramoto, S., Fuyama, Y., Eto, Y., Kondo, K., Tanaka, T. Pediatr. Res. (2005) [Pubmed]
  19. Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin. Yoo, J., Omori, M., Gyarmati, D., Zhou, B., Aye, T., Brewer, A., Comeau, M.R., Campbell, D.J., Ziegler, S.F. J. Exp. Med. (2005) [Pubmed]
  20. Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Watanabe, N., Wang, Y.H., Lee, H.K., Ito, T., Wang, Y.H., Cao, W., Liu, Y.J. Nature (2005) [Pubmed]
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