Disease relevance of IKZF4

• In addition, we have shown that MC and EOS interactions can also take part in modulating fibrosis [1].

High impact information on IKZF4

• To determine if degranulated eosinophils are suitable targets for immunolocalization, we performed in vivo distribution and imaging studies in mice, using EOS (a murine monoclonal antibody directed to human eosinophil peroxidase) labeled with indium-111 [2].
• The possible participation of the endogenous opioid system (EOS) in the negative feedback of the hypothalamic-pituitary-adrenal axis (HPA-a) activated by low doses (1 mg) of dexamethasone (Dex) was investigated [3].
• It is, for example, important to define the MC and EOS mediators involved in the modulation of fibroblast properties, and their pattern of influence, keeping in mind the ultimate goal of defining new therapeutic targets for the treatment of fibrotic diseases [1].
• Synthesis of [(18)F]celecoxib was achieved using [(18)F]TBAF in DMSO at 135 degrees C in 10+/-2% yield (EOS) with >99% chemical and radiochemical purities [4].
• Extracellularly loaded NK2935-related responses (EOS) increased in absorbance around 640nm wavelengths and were like action potential in waveform but were slightly preceded by action potential [5].

Anatomical context of IKZF4

• Adult mice were injected intravenously with radiolabeled EOS antibody or with similarly radiolabeled normal mouse IgG before receiving an intramuscular injection into the right thigh of homogenized human eosinophils adsorbed to latex microspheres [2].
• Model analysis showed that EOS consisted of two components, namely 39% non-delay component reflected with sarcolemma action potential and 61% first-order delay component reflected with transverse tubule (T) action potential (delay-constant tau 1 = 0.48 ms) [5].
• The dose of corticosteroids was adjusted according to the standard strategy or the percentage of sputum eosinophils (EOS strategy) [6].
• The white blood cell (WBC) differential plots of all malaria positive samples showed abnormal depolarization events in the NEU-EOS and EOS I plots [7].

Associations of IKZF4 with chemical compounds

• The omega-esterified ceramide classes Cer [EOS], Cer [EOP] and Cer [EOH] contained mostly species with fatty acids >C30 [8].
• The EOS inlays required considerable trimming even when a 15 degrees occlusal divergence of the cavity walls was used [9].
• Method B, using K18F/Kryptofix 222 in acetonitrile provided 5 in multimillicure amounts (30-40% isolated radiochemical yield) with a specific activity of 2-10/mumol (EOS) in less than 60 min [10].

Analytical, diagnostic and therapeutic context of IKZF4

• There was striking localization in the right thigh of the radiolabeled EOS antibody detectable by gamma imaging techniques as soon as 24 hr after injection [2].
• Inlays made by the EOS system required considerable modification of the fitting surface in order for them to fit [9].
• Results showed the EOS system to have the largest marginal gaps before cementation (P < 0.001) [9].
• Twenty obturations were evaluated for each of the following techniques: Group 1, WLC without vibration using the EndoTwinn; Group 2, WLC with heat and vibration using the EndoTwinn; Group 3, WVC using the Elements Obturation System (EOS); Group 4, Injectable GP using the EOS; and Group 5, WVC using the EndoTwinn [11].

References