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Gene Review

ZMAT3  -  zinc finger, matrin-type 3

Homo sapiens

Synonyms: FLJ12296, MGC10613, PAG608, WIG-1, WIG1, ...
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Disease relevance of ZMAT3

  • 3. Investigation of squamous cell carcinomas of the lung by Southern blot and semiquantitative RT-PCR analysis showed amplification in combination with increased expression of WIG-1 in 1/7 tumors and increased expression in a further two cases [1].
  • The human 8 and 6 kb WIG-1 transcripts are both upregulated following ionizing irradiation of the human colon cancer cell lines HCT116 and LoVo which have wild type TP53 but not in DLD1 cells that lack wild type TP53 [1].
  • In the cortex and hippocampal CA1-3 areas, where DNA damage appeared more slowly, pag608 and caspase-3 mRNAs were induced starting 24h after ischemia, and remained elevated even after two to four days [2].

High impact information on ZMAT3


Biological context of ZMAT3

  • However, the mechanisms by which PAG608 is involved in the apoptosis of neuronal cells are still obscure [4].
  • The WIG-1 protein contains three zinc finger motifs and a putative nuclear localization signal [5].

Anatomical context of ZMAT3


Associations of ZMAT3 with chemical compounds

  • Subsequently, pag608 and caspase-3 mRNA levels increased, closely in parallel with the appearance of DNA fragmented cells, but slightly prior to the deterioration of adenosine 5'-triphosphate state [2].

Other interactions of ZMAT3

  • The levels of pag608 and caspase-3 mRNAs were similar at rostral and caudal levels of the cortex, as well as in the hippocampal CA1 and CA3 area, although the degree of injury differed considerably between these structures [2].


  1. Cloning and chromosomal localization of human WIG-1/PAG608 and demonstration of amplification with increased expression in primary squamous cell carcinoma of the lung. Varmeh-Ziaie, S., Ichimura, K., Yang, F., Rabbits, P., Collins, V.P. Cancer Lett. (2001) [Pubmed]
  2. Expression of redox factor-1, p53-activated gene 608 and caspase-3 messenger RNAs following repeated unilateral common carotid artery occlusion in gerbils--relationship to delayed cell injury and secondary failure of energy state. Hermann, D.M., Kuroiwa, T., Hata, R., Gillardon, F., Ito, U., Mies, G. Neuroscience (2001) [Pubmed]
  3. A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis. Israeli, D., Tessler, E., Haupt, Y., Elkeles, A., Wilder, S., Amson, R., Telerman, A., Oren, M. EMBO J. (1997) [Pubmed]
  4. The p53-activated gene, PAG608, requires a zinc finger domain for nuclear localization and oxidative stress-induced apoptosis. Higashi, Y., Asanuma, M., Miyazaki, I., Haque, M.E., Fujita, N., Tanaka, K., Ogawa, N. J. Biol. Chem. (2002) [Pubmed]
  5. Wig-1, a new p53-induced gene encoding a zinc finger protein. Varmeh-Ziaie, S., Okan, I., Wang, Y., Magnusson, K.P., Warthoe, P., Strauss, M., Wiman, K.G. Oncogene (1997) [Pubmed]
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