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Chemical Compound Review

Thiouracil     2-sulfanylidene-1H-pyrimidin- 4-one

Synonyms: Deracil, Nobilen, Tiouracyl, Antagothyroid, Antagothyroil, ...
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Disease relevance of Thiouracil


Psychiatry related information on Thiouracil

  • Detection threshold for the taste of PROP (6-n-propyl thiouracil) in aqueous solution was determined in 173 French Caucasian women deprived of retronasal olfaction by blowing an air stream into the nostrils [6].
  • The thiouracil-treated rats displayed reduced fearfulness in lever-touching and lever-pressing tasks in operant conditioning chambers and in their initial adaptation to activity-wheel and maze apparatuses [7].

High impact information on Thiouracil

  • Feeding of the goitrogen, thiouracil, which stimulates secretion of thyroid-stimulating hormone, resulted in the appearance of some very narrow and some very wide, tight junctions or sometimes junctions with both wide and narrow regions within the same cell [8].
  • The addition of ET-1 and ET-2 at 1-50 nM concentrations caused human melanocytes to significantly stimulate DNA [( 3H]thymidine incorporation) and melanin synthesis (3H2O release and [14C] thiouracil incorporation) [9].
  • After goiter formation was induced by thiouracil and a low iodine diet, there was increased expression of the genes encoding ET-related proteins (ET-1, 3.2-fold; ETA, 2.9-fold; ETB, 3.5-fold) as well as two of the three NOS isoforms (NOS I, 2.7-fold; NOS III, 4.9-fold) [10].
  • Over a period of 8 weeks, ram lambs were made hypothyroid (serum T4 less than or equal to 3 ng/ml compared with controls congruent to 30 ng/ml) by daily oral administration of methyl thiouracil or hyperthyroid (serum T4 congruent to 135 ng/ml) by daily sc injection of T4 [11].
  • Capillary endothelial cell multiplication in adipose tissue pads on the thyroid during the feeding of thiouracil [12].

Chemical compound and disease context of Thiouracil


Biological context of Thiouracil


Anatomical context of Thiouracil


Associations of Thiouracil with other chemical compounds


Gene context of Thiouracil


Analytical, diagnostic and therapeutic context of Thiouracil


  1. Stimulation by thyroid-stimulating hormone and Grave's immunoglobulin G of vascular endothelial growth factor mRNA expression in human thyroid follicles in vitro and flt mRNA expression in the rat thyroid in vivo. Sato, K., Yamazaki, K., Shizume, K., Kanaji, Y., Obara, T., Ohsumi, K., Demura, H., Yamaguchi, S., Shibuya, M. J. Clin. Invest. (1995) [Pubmed]
  2. Interaction of tetraiodofluorescein with a modified form of aspartate transcarbamylase. Kantrowitz, E.R., Jacobsberg, L.B., Landfear, S.M., Lipscomb, W.N. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  3. Thiouracil distribution in mice carrying transplantable melanoma. Fairchild, R.G., Packer, S., Greenberg, D., Som, P., Brill, A.B., Fand, I., McNally, W.P. Cancer Res. (1982) [Pubmed]
  4. The epizootiology and pathogenesis of thyroid hyperplasia in coho salmon (Oncorhynchus kisutch) in Lake Ontario. Sonstegard, R., Leatherland, J.F. Cancer Res. (1976) [Pubmed]
  5. Microhemorrhage in the hyperplastic thyroid gland of the rat. Zeilgs, J.D., Wollman, S.H. Am. J. Pathol. (1976) [Pubmed]
  6. Influence of PROP-sensitivity on taste perceptions and hedonics in French women. A study performed without retronasal olfaction. Smagghe, K., Louis-Sylvestre, J. Appetite. (1998) [Pubmed]
  7. Perinatal hypothyroidism in rats: persistent motivational and metabolic effects. Davenport, J.W., Hennies, R.S. Developmental psychobiology. (1976) [Pubmed]
  8. Changes in tight junctions of thyroid epithelium with changes in thyroid activity. Tice, L.W., Wollman, S.H., Carter, R.C. J. Cell Biol. (1975) [Pubmed]
  9. Effects of endothelins on signal transduction and proliferation in human melanocytes. Yada, Y., Higuchi, K., Imokawa, G. J. Biol. Chem. (1991) [Pubmed]
  10. Expression of nitric oxide synthase isoforms in the thyroid gland: evidence for a role of nitric oxide in vascular control during goiter formation. Colin, I.M., Nava, E., Toussaint, D., Maiter, D.M., vanDenhove, M.F., Lüscher, T.F., Ketelslegers, J.M., Denef, J.F., Jameson, J.L. Endocrinology (1995) [Pubmed]
  11. Activity of the hypothalamo-pituitary axis and testicular development in prepubertal ram lambs with induced hypothyroidism or hyperthyroidism. Chandrasekhar, Y., D'Occhio, M.J., Holland, M.K., Setchell, B.P. Endocrinology (1985) [Pubmed]
  12. Capillary endothelial cell multiplication in adipose tissue pads on the thyroid during the feeding of thiouracil. Smeds, S., Wollman, S.H. Endocrinology (1983) [Pubmed]
  13. Hypersecretion of corticotrophin-releasing hormone and arginine vasopressin in hypothyroid male rats as estimated with push-pull perfusion. Tohei, A., Watanabe, G., Taya, K. J. Endocrinol. (1998) [Pubmed]
  14. Effects of ascorbic acid on plasma thyroxine concentrations and eggshell quality of Leghorn chickens treated with dietary thiouracil. Peebles, E.D., Miller, E.H., Brake, J.D., Schultz, C.D. Poult. Sci. (1992) [Pubmed]
  15. Positron emission tomography of experimental melanoma with. Mårs, U., Tolmachev, V., Sundin, A. Nucl. Med. Biol. (2000) [Pubmed]
  16. The effect of methionine, thiouracil, dienestrol diacetate and thyroprotein on the development and prevention of fatty liver in pullets. Roberson, R.H., Trujillo, T. Poult. Sci. (1975) [Pubmed]
  17. Melanin-affinic thioureas as selective melanoma seekers. Larsson, B.S. Melanoma Res. (1991) [Pubmed]
  18. Lipolysis and blood capillary enlargement in adipose tissue pads on thyroids of rats fed thiouracil. Wollman, S.H., Herveg, J.P., Smeds, S. Endocrinology (1982) [Pubmed]
  19. Thiouracil and antibody titers of chickens from lines divergently selected for antibody response to sheep erythrocytes. Martin, A., McNabb, F.M., Siegel, P.B. Dev. Comp. Immunol. (1988) [Pubmed]
  20. Stimulation by propylthiouracil of the hexose monophosphate shunt in human polymorphonuclear leucocytes during phagocytosis. Tsan, M.F., McIntyre, P.A. Br. J. Haematol. (1975) [Pubmed]
  21. Effects of hypothyroidism on vascular 125I-albumin permeation and blood flow in rats. Tilton, R.G., Pugliese, G., Chang, K., Speedy, A., Province, M.A., Kilo, C., Williamson, J.R. Metab. Clin. Exp. (1989) [Pubmed]
  22. The role of thyroid hormone in the development of the chick corneal endothelium and epithelium. Masterson, E., Edelhauser, H.F., Van Horn, D.L. Invest. Ophthalmol. Vis. Sci. (1977) [Pubmed]
  23. Effect of thiouracil upon canine arterial elastic tissue. Trillo, A. Atherosclerosis (1975) [Pubmed]
  24. Thiourea and cyanamide as inhibitors of thyroid peroxidase: the role of iodide. Davidson, B., Soodak, M., Strout, H.V., Neary, J.T., Nakamura, C., Maloof, F. Endocrinology (1979) [Pubmed]
  25. Stimulation of melanotic expression in a melanoma cell line by theophylline. Steinberg, M.L., Whittaker, J.R. J. Cell. Physiol. (1976) [Pubmed]
  26. Effects of dextrothyroxine on hyperlipidemia and experimental atherosclerosis in beagle dogs. Nandan, R., Fisher, J.D., Towery, E.P., Brown, D.R., Ganote, E., Jennings, R.B. Atherosclerosis (1975) [Pubmed]
  27. Experimental hyper-beta-lipoproteinemia and its amelioration by a novel hypolipidemic agent. Kobayakawa, T., Osuga, K., Yasuda, H. Atherosclerosis (1978) [Pubmed]
  28. Interaction of propylthiouracil and its precursors with horseradish peroxidase. Zaton, A., Ochoa de Aspuru, E. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  29. Sporadic non-toxic goitre: an investigation of the hypothalamic-pituitary-thyroid axis. Morgans, M.E., Thompson, B.D., Whitehouse, S.A. Clin. Endocrinol. (Oxf) (1978) [Pubmed]
  30. Relationship of polycystic ovary induction to prolactin secretion: prevention of cyst formation by bromocriptine in the rat. Copmann, T.L., Adams, W.C. Endocrinology (1981) [Pubmed]
  31. Hypothalamic CRF immunoreactivity in genetically hypothyroid (hyt/hyt) mice. Meserve, L.A. Proc. Soc. Exp. Biol. Med. (1987) [Pubmed]
  32. Different approaches for assaying melanosome transfer. Berens, W., Van Den Bossche, K., Yoon, T.J., Westbroek, W., Valencia, J.C., Out, C.J., Marie Naeyaert, J., Hearing, V.J., Lambert, J. Pigment Cell Res. (2005) [Pubmed]
  33. Effect of thiouracil in modifying folate function in severe vitamin B12 deficiency. Keating, J.N., Kusano, G., Stokstad, E.L. Arch. Biochem. Biophys. (1988) [Pubmed]
  34. Boron-containing thiouracil derivatives for neutron-capture therapy of melanoma. Tjarks, W., Gabel, D. J. Med. Chem. (1991) [Pubmed]
  35. Accumulation and localization of radiocalcium in the rat thyroid gland. Haeberli, A., Millar, F.K., Wollman, S.H. Endocrinology (1978) [Pubmed]
  36. Effect of hypothyroidism on methylmalonate excretion and hepatic vitamin B-12 levels in rats. Stokstad, E.L., Nair, C.P. J. Nutr. (1988) [Pubmed]
  37. Therapeutic effects of S-35-thiouracil in BALB/c mice carrying Harding-Passey melanoma. Fairchild, R.G., Coderre, J.A., Packer, S., Greenberg, D., Laster, B.H. Int. J. Radiat. Oncol. Biol. Phys. (1989) [Pubmed]
  38. Summary of observations on transplantable tumors of the rat thyroid gland. Wollman, S.H. Biochimie (1999) [Pubmed]
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