High impact information on Arl6ip5

• Previous studies suggest that retinoic acid (RA) decreases Na+-dependent glutamate uptake and increases GTRAP3-18 protein expression [1].
• Intracerebroventricular administration of MebetaCD to the mouse brain resulted in a significant increase in GTRAP3-18 immunoreactivity in the hippocampus and cerebral cortex [1].
• Mouse and human GTRAP3-18 genes contain three exons separated by two introns [2].
• The GTRAP3-18 gene is found on mouse chromosome 6D3 and on human chromosome 3p14, a susceptibility locus for cancer and epilepsy [2].
• GTRAP3-18 protein and RNA were found both in neuronal rich regions of the brain and in non-neuronal tissues such as the kidney, heart and skeletal muscle [2].

Biological context of Arl6ip5

• Northern blot analysis revealed that addicsin mRNA levels increased with maturation, reaching their maximum level at postnatal day 5 (P5), then significantly declined by about 50% until P14, suggesting that addicsin may contribute to embryogenesis and synaptogenesis in the developing brain [3].
• Up-regulation of addicsin expression by morphine may affect glutamate uptake in the amygdala, causing mice to develop morphine tolerance and dependence [4].

Anatomical context of Arl6ip5

• In the hippocampus, addicsin mRNA was expressed in the neuron-like cells of the CA1-CA3 pyramidal cell layer and the interneuron-like cells of the stratum oriens, stratum radiatum and stratum lacunosum-moleculare [3].
• In the mature brain, we found addicsin mRNA to be ubiquitously expressed in neuron-like cells, but not glial cells, in various brain regions including the olfactory bulbs, hippocampus and cerebral cortex [3].
• Addicsin transcripts were also extremely abundant in trigeminal neurons such as the principal trigeminal nucleus, mesencephalic trigeminal nucleus and motor trigeminal nucleus [3].

Associations of Arl6ip5 with chemical compounds

• Our evidence suggests that addicsin mRNA is chiefly expressed in the excitatory and inhibitory neurons, and that addicsin may participate in the functional expression of the somatic sensory system by modulation of EAAC1-mediated glutamate transport [3].

Analytical, diagnostic and therapeutic context of Arl6ip5

• We analyzed here the regional and cellular distribution of addicsin transcript in the mature brain using in situ hybridization analysis, and examined the sequential addicsin mRNA expression levels in the developing brain using Northern blot analysis [3].

References