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Gene Review

Slc1a1  -  solute carrier family 1...

Mus musculus

Synonyms: D130048G10Rik, EAAC1, EAAC2, EAAT3, Eaac1, ...
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Disease relevance of Slc1a1


High impact information on Slc1a1


Biological context of Slc1a1


Anatomical context of Slc1a1

  • MEAAC1 mRNA was expressed in brain, lung, kidney and skeletal muscle, whereas expression of MGLT1 was restricted to brain [5].
  • A comparison of responses recorded from wild-type and transporter knock-out mice revealed that the astroglial glutamate transporters GLT-1 and GLAST, but not the neuronal transporter EAAC1, restrict activation of mGluRs in O-LM interneurons [9].
  • To investigate the specific physiological and pathophysiological role of the neuronal EAAC-1, which is also expressed in kidney and small intestine, we have generated two independent mouse lines lacking EAAC-1. eaac-1(-/-) mice develop dicarboxylic aminoaciduria [10].
  • Lack of glutamate transporter EAAC1 in the epididymis of infertile c-ros receptor tyrosine-kinase deficient mice [6].
  • Immunohistochemical staining for EAAC1 confirmed regional mRNA expression and demonstrated an adluminal location on stereocilia/microvilli of principal cells [6].

Associations of Slc1a1 with chemical compounds

  • Our evidence suggests that addicsin mRNA is chiefly expressed in the excitatory and inhibitory neurons, and that addicsin may participate in the functional expression of the somatic sensory system by modulation of EAAC1-mediated glutamate transport [11].
  • The non-selective EAAT inhibitor threo-beta-hydroxyaspartate had a significantly greater maximal inhibitory effect than did the EAAT2-selective inhibitor, dihydrokainate, indicating uptake by both EAAT2 and EAAT3 [12].
  • Structure activity studies on a series of beta-substituted aspartate analogues identify L-beta-benzyl-aspartate (L-beta-BA) as among the first blockers that potently and preferentially inhibits the neuronal EAAT3 subtype [13].
  • The increase in luminal fluid pH in the KO mice could also be contributed to by other epithelial regulating factors including the Na(+)-dependent glutamate transporter EAAC1 formerly reported to be down regulated in the KO [14].
  • Administration of dihydrotestosterone (DHT) to the castrates maintained the proximal and distal caput epithelia and induced a proximal epithelium, which resembled the initial segment in its prominent staining for Golgi, EAAC1 and beta-Gal activity, although it was short and exhibited no MEP17 expression [15].

Other interactions of Slc1a1

  • Immunohistochemical analysis demonstrated a region-specific modification of neuronal glutamate transporter, EAAT3 trafficking in the GFAP null phenotype [16].
  • The glutamate transporters EAAC1 (EAAT3) and EAAT5 were downregulated and upregulated, respectively [17].
  • Electron-microscopically, EAAC1 immunoreactivity was predominantly localized in the striated border of enterocytes [18].
  • Evidence that Akt mediates platelet-derived growth factor-dependent increases in activity and surface expression of the neuronal glutamate transporter, EAAC1 [3].
  • Functional significance of N- and C-terminus of the amino acid transporters EAAC1 and ASCT1: characterization of chimeric transporters [19].

Analytical, diagnostic and therapeutic context of Slc1a1


  1. Glutamate transporters in the spinal cord of the wobbler mouse. Bigini, P., Bastone, A., Mennini, T. Neuroreport (2001) [Pubmed]
  2. The glutamate and neutral amino acid transporter family: physiological and pharmacological implications. Kanai, Y., Hediger, M.A. Eur. J. Pharmacol. (2003) [Pubmed]
  3. Evidence that Akt mediates platelet-derived growth factor-dependent increases in activity and surface expression of the neuronal glutamate transporter, EAAC1. Krizman-Genda, E., González, M.I., Zelenaia, O., Robinson, M.B. Neuropharmacology (2005) [Pubmed]
  4. Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Aoyama, K., Suh, S.W., Hamby, A.M., Liu, J., Chan, W.Y., Chen, Y., Swanson, R.A. Nat. Neurosci. (2006) [Pubmed]
  5. Molecular cloning of two glutamate transporter subtypes from mouse brain. Mukainaka, Y., Tanaka, K., Hagiwara, T., Wada, K. Biochim. Biophys. Acta (1995) [Pubmed]
  6. Lack of glutamate transporter EAAC1 in the epididymis of infertile c-ros receptor tyrosine-kinase deficient mice. Wagenfeld, A., Yeung, C.H., Lehnert, W., Nieschlag, E., Cooper, T.G. J. Androl. (2002) [Pubmed]
  7. A mRNA molecule encoding truncated excitatory amino acid carrier 1 (EAAC1) protein (EAAC2) is transcribed from an independent promoter but not an alternative splicing event. Jin, X.P., Peng, J.B., Huang, F., Zhu, Y.N., Fei, J., Guo, L.H. Cell Res. (2002) [Pubmed]
  8. Functional analysis of glutamate transporters in excitatory synaptic transmission of GLAST1 and GLAST1/EAAC1 deficient mice. Stoffel, W., Körner, R., Wachtmann, D., Keller, B.U. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  9. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. Huang, Y.H., Sinha, S.R., Tanaka, K., Rothstein, J.D., Bergles, D.E. J. Neurosci. (2004) [Pubmed]
  10. Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration. Peghini, P., Janzen, J., Stoffel, W. EMBO J. (1997) [Pubmed]
  11. Expression profile of addicsin/GTRAP3-18 mRNA in mouse brain. Inoue, K., Akiduki, S., Ikemoto, M.J. Neurosci. Lett. (2005) [Pubmed]
  12. The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures. Chen, Y., Swanson, R.A. J. Neurochem. (2003) [Pubmed]
  13. The substituted aspartate analogue L-beta-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3. Esslinger, C.S., Agarwal, S., Gerdes, J., Wilson, P.A., Davis, E.S., Awes, A.N., O'Brien, E., Mavencamp, T., Koch, H.P., Poulsen, D.J., Rhoderick, J.F., Chamberlin, A.R., Kavanaugh, M.P., Bridges, R.J. Neuropharmacology (2005) [Pubmed]
  14. Increased luminal pH in the epididymis of infertile c-ros knockout mice and the expression of sodium-hydrogen exchangers and vacuolar proton pump H+-ATPase. Yeung, C.H., Breton, S., Setiawan, I., Xu, Y., Lang, F., Cooper, T.G. Mol. Reprod. Dev. (2004) [Pubmed]
  15. Regulation of the initial segment of the murine epididymis by dihydrotestosterone and testicular exocrine secretions studied by expression of specific proteins and gene expression. Avram, C., Yeung, C.H., Nieschlag, E., Cooper, T.G. Cell Tissue Res. (2004) [Pubmed]
  16. Loss of glial fibrillary acidic protein results in decreased glutamate transport and inhibition of PKA-induced EAAT2 cell surface trafficking. Hughes, E.G., Maguire, J.L., McMinn, M.T., Scholz, R.E., Sutherland, M.L. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  17. Gene and protein expression in the epididymis of infertile c-ros receptor tyrosine kinase-deficient mice. Cooper, T.G., Wagenfeld, A., Cornwall, G.A., Hsia, N., Chu, S.T., Orgebin-Crist, M.C., Drevet, J., Vernet, P., Avram, C., Nieschlag, E., Yeung, C.H. Biol. Reprod. (2003) [Pubmed]
  18. Cellular distribution of glutamate transporters in the gastrointestinal tract of mice: an immunohistochemical and in situ hybridization approach. Iwanaga, T., Goto, M., Watanabe, M. Biomed. Res. (2005) [Pubmed]
  19. Functional significance of N- and C-terminus of the amino acid transporters EAAC1 and ASCT1: characterization of chimeric transporters. Li, J., Fei, J., Huang, F., Guo, L.H., Schwarz, W. Biochim. Biophys. Acta (2000) [Pubmed]
  20. The 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings. Suchak, S.K., Baloyianni, N.V., Perkinton, M.S., Williams, R.J., Meldrum, B.S., Rattray, M. J. Neurochem. (2003) [Pubmed]
  21. Synaptic nests lack glutamate transporters in the cochlear nucleus of the mouse. Josephson, E.M., Morest, D.K. Synapse (2003) [Pubmed]
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