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Gene Review

SLC1A7  -  solute carrier family 1 (glutamate...

Homo sapiens

Synonyms: AAAT, EAAT5, Excitatory amino acid transporter 5, Retinal glutamate transporter, Solute carrier family 1 member 7
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High impact information on SLC1A7


Biological context of SLC1A7

  • New alleles at the AAAT-repeat were found in one NF1 family and in three CEPH families giving a mutation rate for this AAAT-repeat of 0.36% per allele, which is one of the highest detected for a microsatellite locus [2].
  • Base sequence specific binding of DST was also found for the 1:1 complex formation at the 4-base-paired sites, with AAAA, TTTT, ATTT, and AAAT sequences exhibiting the highest binding affinities [3].
  • MPE-Fe(EDTA) footprinting of a novel monocationic bis-furan lexitropsin 6 on a HindIII/EcoRI restriction fragment of pBR322 DNA revealed a series of four-base binding sites (all 5'----3') of (primary) TGTA, TGAA, AAAT, ACAA, TTAT, and (secondary) CTAA, TCGT, TGTA, GTCA, and GGTT [4].

Anatomical context of SLC1A7


  1. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Arriza, J.L., Eliasof, S., Kavanaugh, M.P., Amara, S.G. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Novel alleles, hemizygosity and deletions at an Alu-repeat within the neurofibromatosis type 1 (NF1) gene. Lázaro, C., Gaona, A., Ravella, A., Volpini, V., Casals, T., Fuentes, J.J., Estivill, X. Hum. Mol. Genet. (1993) [Pubmed]
  3. Circular dichroic and kinetic differentiation of DNA binding modes of distamycin. Chen, F.M., Sha, F. Biochemistry (1998) [Pubmed]
  4. Molecular recognition between oligopeptides and nucleic acids. Specificity of binding of a monocationic bis-furan lexitropsin to DNA deduced from footprinting and 1H NMR studies. Lee, M., Krowicki, K., Shea, R.G., Lown, J.W., Pon, R.T. J. Mol. Recognit. (1989) [Pubmed]
  5. A new GLT1 splice variant: cloning and immunolocalization of GLT1c in the mammalian retina and brain. Rauen, T., Wiessner, M., Sullivan, R., Lee, A., Pow, D.V. Neurochem. Int. (2004) [Pubmed]
  6. Are neuronal transporters relevant in retinal glutamate homeostasis? Pow, D.V., Barnett, N.L., Penfold, P. Neurochem. Int. (2000) [Pubmed]
  7. Excitatory amino acid transporters: keeping up with glutamate. Amara, S.G., Fontana, A.C. Neurochem. Int. (2002) [Pubmed]
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