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Gene Review

SLC1A1  -  solute carrier family 1...

Homo sapiens

Synonyms: DCBXA, EAAC1, EAAT3, Excitatory amino acid transporter 3, Excitatory amino-acid carrier 1, ...
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Disease relevance of SLC1A1


Psychiatry related information on SLC1A1


High impact information on SLC1A1


Chemical compound and disease context of SLC1A1


Biological context of SLC1A1


Anatomical context of SLC1A1


Associations of SLC1A1 with chemical compounds


Physical interactions of SLC1A1

  • Expression of a dominant-negative variant of SNAP-23 that lacks a domain required for SNARE complex assembly decreased the fraction of EAAC1 found on the cell surface and decreased total EAAC1 expression, while two control constructs had no effect [24].

Regulatory relationships of SLC1A1

  • Intracerebral administration of either anti-TNF-alpha antibody or of a TNFR1 antisense oligodeoxynucleotide also inhibited ischemic preconditioning-induced EAAT3 up-regulation [25].
  • Syntaxin 1A promotes the endocytic sorting of EAAC1 leading to inhibition of glutamate transport [26].

Other interactions of SLC1A1


Analytical, diagnostic and therapeutic context of SLC1A1


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  2. Assignment of the gene coding for the human high-affinity glutamate transporter EAAC1 to 9p24: potential role in dicarboxylic aminoaciduria and neurodegenerative disorders. Smith, C.P., Weremowicz, S., Kanai, Y., Stelzner, M., Morton, C.C., Hediger, M.A. Genomics (1994) [Pubmed]
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  4. Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins. Aronica, E., Gorter, J.A., Ijlst-Keizers, H., Rozemuller, A.J., Yankaya, B., Leenstra, S., Troost, D. Eur. J. Neurosci. (2003) [Pubmed]
  5. Rat C6 and human astrocytic tumor cells express a neuronal type of glutamate transporter. Palos, T.P., Ramachandran, B., Boado, R., Howard, B.D. Brain Res. Mol. Brain Res. (1996) [Pubmed]
  6. Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder. Veenstra-VanderWeele, J., Kim, S.J., Gonen, D., Hanna, G.L., Leventhal, B.L., Cook, E.H. Mol. Psychiatry (2001) [Pubmed]
  7. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Jackson, M., Song, W., Liu, M.Y., Jin, L., Dykes-Hoberg, M., Lin, C.I., Bowers, W.J., Federoff, H.J., Sternweis, P.C., Rothstein, J.D. Nature (2001) [Pubmed]
  8. Flux coupling in a neuronal glutamate transporter. Zerangue, N., Kavanaugh, M.P. Nature (1996) [Pubmed]
  9. Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder. Arnold, P.D., Sicard, T., Burroughs, E., Richter, M.A., Kennedy, J.L. Arch. Gen. Psychiatry (2006) [Pubmed]
  10. Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder. Dickel, D.E., Veenstra-VanderWeele, J., Cox, N.J., Wu, X., Fischer, D.J., Van Etten-Lee, M., Himle, J.A., Leventhal, B.L., Cook, E.H., Hanna, G.L. Arch. Gen. Psychiatry (2006) [Pubmed]
  11. Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma. Davis, K.E., Straff, D.J., Weinstein, E.A., Bannerman, P.G., Correale, D.M., Rothstein, J.D., Robinson, M.B. J. Neurosci. (1998) [Pubmed]
  12. Chronological changes of N-methyl-D-aspartate receptors and excitatory amino acid carrier 1 immunoreactivities in CA1 area and subiculum after transient forebrain ischemia. Kang, T.C., Hwang, I.K., Park, S.K., An, S.J., Yoon, D.K., Moon, S.M., Lee, Y.B., Sohn, H.S., Cho, S.S., Won, M.H. J. Neurocytol. (2001) [Pubmed]
  13. Stereoselective Chemoenzymatic Synthesis of the Four Stereoisomers of l-2-(2-Carboxycyclobutyl)glycine and Pharmacological Characterization at Human Excitatory Amino Acid Transporter Subtypes 1, 2, and 3. Faure, S., Jensen, A.A., Maurat, V., Gu, X., Sagot, E., Aitken, D.J., Bolte, J., Gefflaut, T., Bunch, L. J. Med. Chem. (2006) [Pubmed]
  14. Increased expression of the neuronal glutamate transporter (EAAT3/EAAC1) in hippocampal and neocortical epilepsy. Crino, P.B., Jin, H., Shumate, M.D., Robinson, M.B., Coulter, D.A., Brooks-Kayal, A.R. Epilepsia (2002) [Pubmed]
  15. Distribution of glutamate transporters in the human placenta. Noorlander, C.W., de Graan, P.N., Nikkels, P.G., Schrama, L.H., Visser, G.H. Placenta (2004) [Pubmed]
  16. The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse? Nieoullon, A., Canolle, B., Masmejean, F., Guillet, B., Pisano, P., Lortet, S. J. Neurochem. (2006) [Pubmed]
  17. Distribution of glutamate transporter subtypes during human brain development. Bar-Peled, O., Ben-Hur, H., Biegon, A., Groner, Y., Dewhurst, S., Furuta, A., Rothstein, J.D. J. Neurochem. (1997) [Pubmed]
  18. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Rothstein, J.D., Van Kammen, M., Levey, A.I., Martin, L.J., Kuncl, R.W. Ann. Neurol. (1995) [Pubmed]
  19. Interaction of L-cysteine with a human excitatory amino acid transporter. Zerangue, N., Kavanaugh, M.P. J. Physiol. (Lond.) (1996) [Pubmed]
  20. Benzodiazepines differently modulate EAAT1/GLAST and EAAT2/GLT1 glutamate transporters expressed in CHO cells. Palmada, M., Kinne-Saffran, E., Centelles, J.J., Kinne, R.K. Neurochem. Int. (2002) [Pubmed]
  21. Gene expression profiling of human endometrial receptivity on days LH+2 versus LH+7 by microarray technology. Riesewijk, A., Martín, J., van Os, R., Horcajadas, J.A., Polman, J., Pellicer, A., Mosselman, S., Simón, C. Mol. Hum. Reprod. (2003) [Pubmed]
  22. Multiple Consequences of Mutating Two Conserved beta-Bridge Forming Residues in the Translocation Cycle of a Neuronal Glutamate Transporter. Rosental, N., Bendahan, A., Kanner, B.I. J. Biol. Chem. (2006) [Pubmed]
  23. Critical Role of Serine 465 in Isoflurane-induced Increase of Cell-surface Redistribution and Activity of Glutamate Transporter Type 3. Huang, Y., Feng, X., Sando, J.J., Zuo, Z. J. Biol. Chem. (2006) [Pubmed]
  24. A dominant-negative variant of SNAP-23 decreases the cell surface expression of the neuronal glutamate transporter EAAC1 by slowing constitutive delivery. Fournier, K.M., Robinson, M.B. Neurochem. Int. (2006) [Pubmed]
  25. TNFR1 mediates increased neuronal membrane EAAT3 expression after in vivo cerebral ischemic preconditioning. Pradillo, J.M., Hurtado, O., Romera, C., Cárdenas, A., Fernández-Tomé, P., Alonso-Escolano, D., Lorenzo, P., Moro, M.A., Lizasoain, I. Neuroscience (2006) [Pubmed]
  26. Syntaxin 1A promotes the endocytic sorting of EAAC1 leading to inhibition of glutamate transport. Yu, Y.X., Shen, L., Xia, P., Tang, Y.W., Bao, L., Pei, G. J. Cell. Sci. (2006) [Pubmed]
  27. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. Arriza, J.L., Fairman, W.A., Wadiche, J.I., Murdoch, G.H., Kavanaugh, M.P., Amara, S.G. J. Neurosci. (1994) [Pubmed]
  28. GABA and glutamate transporters are expressed in human platelets. Rainesalo, S., Keränen, T., Saransaari, P., Honkaniemi, J. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  29. Excitatory amino acid transporters: keeping up with glutamate. Amara, S.G., Fontana, A.C. Neurochem. Int. (2002) [Pubmed]
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  31. Brain glutamate transporter proteins form homomultimers. Haugeto, O., Ullensvang, K., Levy, L.M., Chaudhry, F.A., Honoré, T., Nielsen, M., Lehre, K.P., Danbolt, N.C. J. Biol. Chem. (1996) [Pubmed]
  32. Increased internalisation and degradation of GLT-1 glial glutamate transporter in a cell model for familial amyotrophic lateral sclerosis (ALS). Vanoni, C., Massari, S., Losa, M., Carrega, P., Perego, C., Conforti, L., Pietrini, G. J. Cell. Sci. (2004) [Pubmed]
  33. Glial glutamate transporter GLT-1 down-regulation precedes delayed neuronal death in gerbil hippocampus following transient global cerebral ischemia. Raghavendra Rao, V.L., Rao, A.M., Dogan, A., Bowen, K.K., Hatcher, J., Rothstein, J.D., Dempsey, R.J. Neurochem. Int. (2000) [Pubmed]
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