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Gene Review

Fgfr1  -  Fibroblast growth factor receptor 1

Rattus norvegicus

Synonyms: Basic fibroblast growth factor receptor 1, FGFR-1, Flg, MFR, Proto-oncogene c-Fgr, ...
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Disease relevance of Fgfr1

  • This study unequivocally demonstrates coordinate up-regulation and trafficking of FGF-2 and full-length FGFR1 to the nucleus of reactive astrocytes in an in vivo model of brain injury, thereby implicating a role in nuclear activity for these molecules [1].
  • A recombinant adenovirus encoding a truncated murine FGFR-1 lacking the kinase domain (DN-FGFR) efficiently expressed the transgene in cultured rat aortic smooth muscle cells [2].
  • Within hours after experimental retinal detachment or focal injury, there is a twofold increase in FGFR1 immunoreactivity in the outer nuclear layer that persists for at least 7 days; a similar increase in bFGF immunoreactivity in the interphotoreceptor matrix is also apparent [3].
  • These data demonstrate a time course for astrocyte expression of FGFR that precedes and parallels the time course for astrocyte hypertrophy [4].
  • Gene expressions of bFGF and FGFR1 were detected in the ganglion cell and inner nuclear layers of the normal adult rat retina [5].

Psychiatry related information on Fgfr1

  • Here, we show that intracerebroventricular administration of the FG loop (FGL), a synthetic 15 amino acid peptide corresponding to the binding site of NCAM for the fibroblast growth factor receptor 1 (FGFR1), immediately after training rats in fear conditioning or water maze learning, induced a long-lasting improvement of memory [6].
  • Rats subjected to eight cycles of food deprivation and refeeding (MFR group) showed significantly decreased circulating leptin levels when compared with control rats (nearly 50% decrease in leptin levels, P < 0.01) [7].

High impact information on Fgfr1


Chemical compound and disease context of Fgfr1


Biological context of Fgfr1


Anatomical context of Fgfr1


Associations of Fgfr1 with chemical compounds


Physical interactions of Fgfr1


Enzymatic interactions of Fgfr1

  • This 79-kDa FGF receptor was not tyrosine-phosphorylated in response to FGF-1 stimulation, while the 128-kDa FGF receptor was recognized by anti-phosphotyrosine antibody under the same conditions [29].

Co-localisations of Fgfr1


Regulatory relationships of Fgfr1


Other interactions of Fgfr1

  • TGF-beta 1 elevated protein and mRNA level of FGF receptor (FGFR) in palatal fibroblasts [23].
  • Unlike FGF-2, the distribution of FGFR1 mRNA correlates well with the presence of the immunoreactive receptor [34].
  • The findings show that chronic alcohol ingestion exerts detrimental effect on the signaling events initiated by bFGF-receptor activation and propagated by Cdk2 that propels the cell cycle progression essential for rapid mucosal repair [35].
  • Gene expression of FGFR-1 was developmentally regulated; expression was higher in prepubertal testes and decreased with sexual maturity [36].
  • Immunoreactivity for receptors (R) for IGF-1 and FGF-2 (IGF-1R, FGFR1, and FGFR3) was most pronounced in chondroblasts and hypertrophic chondrocytes, while FGFR2 immunoreactivity was strongest in the articular and prechondroblastic zones [37].

Analytical, diagnostic and therapeutic context of Fgfr1

  • Western blot analyses indicated that elastase treatment did not release significant amounts of fibroblast growth factor receptor protein [17].
  • Intraperitoneal injection of soluble truncated FGF-R1 at the onset of the recovery phase arrested compensatory lung DNA synthesis and secondary septation seen in control animals after 3 days of recovery, confirming a role for FGF-R1 in this model of compensatory neonatal lung growth [21].
  • Although no definitive evidence for the presence of FGFR-1 in normal LHRH neurons could be obtained by either double immunohistochemistry or double in situ hybridization procedures, fetal LHRH neurons in primary culture responded to bFGF with neurite outgrowth [38].
  • Real time quantitative RT-PCR was used to measure changes in FGFR1 mRNA levels in the retina in response to injury or detachment [3].
  • RESULTS: Confocal immunofluorescence observations showed that FGFR1 immunoreactivity in the rat retina is concentrated primarily in the perinuclear cytoplasm of photoreceptor cell bodies [3].


  1. Coordination of fibroblast growth factor receptor 1 (FGFR1) and fibroblast growth factor-2 (FGF-2) trafficking to nuclei of reactive astrocytes around cerebral lesions in adult rats. Clarke, W.E., Berry, M., Smith, C., Kent, A., Logan, A. Mol. Cell. Neurosci. (2001) [Pubmed]
  2. Autocrine FGF signaling is required for vascular smooth muscle cell survival in vitro. Miyamoto, T., Leconte, I., Swain, J.L., Fox, J.C. J. Cell. Physiol. (1998) [Pubmed]
  3. Rapid upregulation of fibroblast growth factor receptor 1 (flg) by rat photoreceptor cells after injury. Ozaki, S., Radeke, M.J., Anderson, D.H. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  4. Alterations in fibroblast growth factor receptor expression following brain injury. Reilly, J.F., Kumari, V.G. Exp. Neurol. (1996) [Pubmed]
  5. Gene expressions of basic fibroblast growth factor and its receptor in healing of rat retina after laser photocoagulation. Yamamoto, C., Ogata, N., Matsushima, M., Takahashi, K., Miyashiro, M., Yamada, H., Maeda, H., Uyama, M., Matsuzaki, K. Jpn. J. Ophthalmol. (1996) [Pubmed]
  6. A synthetic neural cell adhesion molecule mimetic peptide promotes synaptogenesis, enhances presynaptic function, and facilitates memory consolidation. Cambon, K., Hansen, S.M., Venero, C., Herrero, A.I., Skibo, G., Berezin, V., Bock, E., Sandi, C. J. Neurosci. (2004) [Pubmed]
  7. The effects of weight cycling on serum leptin levels and lipogenic enzyme activities in adipose tissue. Kochan, Z., Karbowska, J., Swierczynski, J. J. Physiol. Pharmacol. (2006) [Pubmed]
  8. Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs. Saffell, J.L., Williams, E.J., Mason, I.J., Walsh, F.S., Doherty, P. Neuron (1997) [Pubmed]
  9. Basic fibroblast growth factor augments podocyte injury and induces glomerulosclerosis in rats with experimental membranous nephropathy. Floege, J., Kriz, W., Schulze, M., Susani, M., Kerjaschki, D., Mooney, A., Couser, W.G., Koch, K.M. J. Clin. Invest. (1995) [Pubmed]
  10. Effects of modulation of basic fibroblast growth factor on tumor growth in vivo. Gross, J.L., Herblin, W.F., Dusak, B.A., Czerniak, P., Diamond, M.D., Sun, T., Eidsvoog, K., Dexter, D.L., Yayon, A. J. Natl. Cancer Inst. (1993) [Pubmed]
  11. Localization of FGF receptor mRNA in the adult rat central nervous system by in situ hybridization. Wanaka, A., Johnson, E.M., Milbrandt, J. Neuron (1990) [Pubmed]
  12. Regulation of basic fibroblast growth factor mRNA expression in rat C6 glioma cells. Powell, P.P., Klagsbrun, M. Exp. Cell Res. (1993) [Pubmed]
  13. Effects of estrogen on cell growth and fibroblast growth factor receptor induction in MtT/Se cells. Takahashi, H., Nakagawa, S. Endocr. Res. (1997) [Pubmed]
  14. In vitro effects of a recombinant toxin targeted to the fibroblast growth factor receptor on rat vascular smooth muscle and endothelial cells. Biro, S., Siegall, C.B., Fu, Y.M., Speir, E., Pastan, I., Epstein, S.E. Circ. Res. (1992) [Pubmed]
  15. Targeting of suicide gene delivery in pancreatic cancer cells via FGF receptors. Kleeff, J., Fukahi, K., Lopez, M.E., Friess, H., Büchler, M.W., Sosnowski, B.A., Korc, M. Cancer Gene Ther. (2002) [Pubmed]
  16. Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine. Corso, T.D., Torres, G., Goulah, C., Roy, I., Gambino, A.S., Nayda, J., Buckley, T., Stachowiak, E.K., Bergey, E.J., Pudavar, H., Dutta, P., Bloom, D.C., Bowers, W.J., Stachowiak, M.K. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  17. Elastase-mediated release of heparan sulfate proteoglycans from pulmonary fibroblast cultures. A mechanism for basic fibroblast growth factor (bFGF) release and attenuation of bfgf binding following elastase-induced injury. Buczek-Thomas, J.A., Nugent, M.A. J. Biol. Chem. (1999) [Pubmed]
  18. Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP. Kiselyov, V.V., Skladchikova, G., Hinsby, A.M., Jensen, P.H., Kulahin, N., Soroka, V., Pedersen, N., Tsetlin, V., Poulsen, F.M., Berezin, V., Bock, E. Structure (Camb.) (2003) [Pubmed]
  19. An NCAM-derived FGF-receptor agonist, the FGL-peptide, induces neurite outgrowth and neuronal survival in primary rat neurons. Neiiendam, J.L., Køhler, L.B., Christensen, C., Li, S., Pedersen, M.V., Ditlevsen, D.K., Kornum, M.K., Kiselyov, V.V., Berezin, V., Bock, E. J. Neurochem. (2004) [Pubmed]
  20. Intracellular trafficking in neurones and glia of fibroblast growth factor-2, fibroblast growth factor receptor 1 and heparan sulphate proteoglycans in the injured adult rat cerebral cortex. Leadbeater, W.E., Gonzalez, A.M., Logaras, N., Berry, M., Turnbull, J.E., Logan, A. J. Neurochem. (2006) [Pubmed]
  21. Fibroblast growth factor receptor-1 and neonatal compensatory lung growth after exposure to 95% oxygen. Jankov, R.P., Luo, X., Campbell, A., Belcastro, R., Cabacungan, J., Johnstone, L., Frndova, H., Lye, S.J., Tanswell, A.K. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  22. Neurite outgrowth induced by a synthetic peptide ligand of neural cell adhesion molecule requires fibroblast growth factor receptor activation. Rønn, L.C., Doherty, P., Holm, A., Berezin, V., Bock, E. J. Neurochem. (2000) [Pubmed]
  23. Basic fibroblast growth factor induces apoptosis in myofibroblastic cells isolated from rat palatal mucosa. Funato, N., Moriyama, K., Shimokawa, H., Kuroda, T. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  24. Increased expression and nuclear accumulation of basic fibroblast growth factor in primary cultured astrocytes following ischemic-like insults. Liu, X., Zhu, X.Z. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  25. Expression of basic fibroblast growth factor and its receptor by smooth muscle cells and endothelium in injured rat arteries. An en face study. Lindner, V., Reidy, M.A. Circ. Res. (1993) [Pubmed]
  26. A synthetic NCAM-derived peptide, FGL, protects hippocampal neurons from ischemic insult both in vitro and in vivo. Skibo, G.G., Lushnikova, I.V., Voronin, K.Y., Dmitrieva, O., Novikova, T., Klementiev, B., Vaudano, E., Berezin, V.A., Bock, E. Eur. J. Neurosci. (2005) [Pubmed]
  27. Basic fibroblast growth factor induces proliferation of a rat pancreatic cancer cell line. Inhibition by somatostatin. Bensaïd, M., Tahiri-Jouti, N., Cambillau, C., Viguerie, N., Colas, B., Vidal, C., Tauber, J.P., Estève, J.P., Susini, C., Vaysse, N. Int. J. Cancer (1992) [Pubmed]
  28. Protein tyrosine kinase activity is required for oxidant-induced extracellular signal-regulated protein kinase activation and c-fos and c-jun expression. Rao, G.N. Cell. Signal. (1997) [Pubmed]
  29. Identification of a 79-kDa heparin-binding fibroblast growth factor (FGF) receptor in rat hepatocytes and its correlation with the different growth responses to FGF-1 between hepatocyte subpopulations. Tanahashi, T., Suzuki, M., Imamura, T., Mitsui, Y. J. Biol. Chem. (1996) [Pubmed]
  30. Expression of the fibroblast growth factor receptor genes in fracture repair. Rundle, C.H., Miyakoshi, N., Ramirez, E., Wergedal, J.E., Lau, K.H., Baylink, D.J. Clin. Orthop. Relat. Res. (2002) [Pubmed]
  31. Permeability of injured blood brain barrier for exogenous bFGF and protection mechanism of bFGF in rat brain ischemia. Liu, Y., Lu, J.B., Ye, Z.R. Neuropathology : official journal of the Japanese Society of Neuropathology. (2006) [Pubmed]
  32. A peptide from the first fibronectin domain of NCAM acts as an inverse agonist and stimulates FGF receptor activation, neurite outgrowth and survival. Anderson, A.A., Kendal, C.E., Garcia-Maya, M., Kenny, A.V., Morris-Triggs, S.A., Wu, T., Reynolds, R., Hohenester, E., Saffell, J.L. J. Neurochem. (2005) [Pubmed]
  33. Lipid metabolism in fibroblast growth factor-stimulated L6 myoblasts: a receptor mutation (Y766F) abrogates phospholipase D and diacylglycerol kinase activities. van Dijk, M.C., van Blitterswijk, W.J. Biochim. Biophys. Acta (1998) [Pubmed]
  34. Fibroblast growth factor in the hypothalamic-pituitary axis: differential expression of fibroblast growth factor-2 and a high affinity receptor. Gonzalez, A.M., Logan, A., Ying, W., Lappi, D.A., Berry, M., Baird, A. Endocrinology (1994) [Pubmed]
  35. Effect of chronic alcohol ingestion on buccal mucosal expression of bFGF and Cdk2 during ulcer healing. Slomiany, B.L., Piotrowski, J., Slomiany, A. Biochem. Mol. Biol. Int. (1998) [Pubmed]
  36. Fibroblast growth factor receptor type 1 expression during rat testicular development and its regulation in cultured Sertoli cells. Le Magueresse-Battistoni, B., Wolff, J., Morera, A.M., Benahmed, M. Endocrinology (1994) [Pubmed]
  37. Regulation of cell proliferation in rat mandibular condylar cartilage in explant culture by insulin-like growth factor-1 and fibroblast growth factor-2. Fuentes, M.A., Opperman, L.A., Bellinger, L.L., Carlson, D.S., Hinton, R.J. Arch. Oral Biol. (2002) [Pubmed]
  38. Neural and glial-mediated effects of growth factors acting via tyrosine kinase receptors on luteinizing hormone-releasing hormone neurons. Voigt, P., Ma, Y.J., Gonzalez, D., Fahrenbach, W.H., Wetsel, W.C., Berg-von der Emde, K., Hill, D.F., Taylor, K.G., Costa, M.E., Seidah, N.G., Ojeda, S.R. Endocrinology (1996) [Pubmed]
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