Disease relevance of SLC7A2

• Marked eosinophilia, associated with up-regulation of eotaxin-1, was present in the bronchoalveolar lavage fluid of 3-week-old CAT2-deficient mice [1].

High impact information on SLC7A2

• Thus, our data suggest that CAT2 regulates anti-inflammatory processes in the lungs via regulation of dendritic cell activation and subsequent T cell responses [1].
• Despite the presence of activated alveolar macrophages in CAT2-deficient mice, NO production was compromised in these cells [1].
• In contrast, Cat3 transcript accumulation was constant and about 10 times higher than that of Cat2 under DD or LL, while the expression of Cat3 exhibits a typical circadian rhythm under a 12h D/L photoperiod [2].
• System y+ plays a minor role in arginine uptake by monocytes and the expression of system y+-related genes, SLC7A1 and SLC7A2, is not changed by IFNgamma [3].
• Using the hCAT-2B cDNA, we assigned the hCAT-2 gene to chromosome 8p22 [4].

Biological context of SLC7A2

• The HCAT2 gene was assigned to human chromosome 8p21.3-p22 [5].
• Human cationic amino acid transporter 2 (HCAT2) was isolated from a human intestine cDNA library [5].
• Molecular cloning, tissue distribution, and chromosomal localization of human cationic amino acid transporter 2 (HCAT2) [5].

Other interactions of SLC7A2

• SLC7A4 displays high homology with SLC7A1 and SLC7A2, two previously known CAA transporters [6].

Analytical, diagnostic and therapeutic context of SLC7A2

• In Northern blot analysis, a single (9.0 kb) HCAT2 mRNA transcript was present in various human tissues [5].

References