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Gene Review

SLC7A4  -  solute carrier family 7, member 4

Homo sapiens

Synonyms: CAT-4, CAT4, Cationic amino acid transporter 4, HCAT3, Solute carrier family 7 member 4, ...
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Disease relevance of SLC7A4


High impact information on SLC7A4

  • In 4 CLL cases with unmutated VH genes, a common minimal 3.5-Mb gain of 2p16 spanning the REL and BCL11A oncogenes was identified, implicating these genes in the pathogenesis of CLL [3].
  • We expressed SLC7A4 in Xenopus laevis oocytes, but could not detect any transport activity for cationic, neutral or anionic amino acids or for the polyamine putrescine [1].
  • Expression of solute carrier 7A4 (SLC7A4) in the plasma membrane is not sufficient to mediate amino acid transport activity [1].
  • However, also for this endogenously expressed SLC7A4, we could not detect any transport activity for l-arginine [1].
  • Member 4 of human solute carrier family 7 (SLC7A4) exhibits significant sequence homology with the SLC7 subfamily of human cationic amino acid transporters (hCATs) [Sperandeo, Borsani, Incerti, Zollo, Rossi, Zuffardi, Castaldo, Taglialatela, Andria and Sebastio (1998) Genomics 49, 230-236] [1].

Biological context of SLC7A4

  • The hCAT-2 gene structure is closely related to the structure of hCAT-1, suggesting that they belong to a common gene family. hCAT-4 consists of only 4 translated exons and 3 short introns [4].
  • By screening an expressed sequence tag database, we identified a novel human gene, SLC7A4, encoding a solute carrier family 7 [cationic amino acid (CAA) CAT-4 transporter, y+ system] member 4 [5].
  • Cationic amino acid transporter (CAT) 1, CAT 4, and 4F2hc were detected using RT-PCR in placentas throughout gestation. rBAT was not detected in term placentas [6].
  • The VH mutational status correlated with high-risk cytogenetic aberrations while no such relation could be demonstrated for specific VH gene usage (V3-21 and V1-69) [2].
  • Mean numbers in Ringers's solution were 90,000 at a hyperpolarizing holding potential VH = -40 mV, 50,000 at the resting potential (VH = 0 mV) and 30,000 at a depolarizing holding potential VH = 30 mV [7].

Anatomical context of SLC7A4

  • Microinjection of SLC7A4 mRNA into Xenopus laevis oocytes demonstrates a significant stimulation of CAA transport [5].
  • Taken together, 62 of 63 cells analyzed harbored somatically mutated VH region genes, indicating that the vast majority of both IgA- and IgM-secreting intestinal plasma cells derive from germinal center B cells [8].
  • Human IgA- and IgM-secreting intestinal plasma cells carry heavily mutated VH region genes [8].
  • Single IgA- or IgM-secreting plasma cells were isolated from histological sections of human jejunum and terminal ileum, and Ig heavy chain variable (VH) region genes were amplified and sequenced [8].
  • The positioning of procaine among the components of human erythrocyte membranes was investigated by electron paramagnetic resonance (EPR) using several spin labelled molecules: fatty acids 5-, 12- and 16-doxyl-stearic acids (5DSA, 12DSA, 16DSA), procaine (SLP) and a quaternary ammonium salt (CAT4) [9].

Enzymatic interactions of SLC7A4


Other interactions of SLC7A4

  • By chromosomal in situ hybridization and YAC identification, SLC7A4 was mapped to 22q11.2, the commonly deleted region of the velocardiofacial syndrome (VCFS, Shprintzen syndrome) [5].
  • Stimulus sets consisted of 92 pictures, divided in four emotional categories that ranged from neutral scenes of domestic objects (CAT1) to extremely negative scenes of mutilation or accidents (CAT4) [10].

Analytical, diagnostic and therapeutic context of SLC7A4


  1. Expression of solute carrier 7A4 (SLC7A4) in the plasma membrane is not sufficient to mediate amino acid transport activity. Wolf, S., Janzen, A., Vékony, N., Martiné, U., Strand, D., Closs, E.I. Biochem. J. (2002) [Pubmed]
  2. Karyotype complexity and VH gene status in B-cell chronic lymphocytic leukemia. M??hes, G., Kov??cs, G., Kajt??r, B., Lacza, A., V??rnai, A., Losonczy, H., Pajor, L. Haematologica (2006) [Pubmed]
  3. Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays. Pfeifer, D., Pantic, M., Skatulla, I., Rawluk, J., Kreutz, C., Martens, U.M., Fisch, P., Timmer, J., Veelken, H. Blood (2007) [Pubmed]
  4. Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4. Hammermann, R., Brunn, G., Racké, K. Amino Acids (2001) [Pubmed]
  5. The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome. Sperandeo, M.P., Borsani, G., Incerti, B., Zollo, M., Rossi, E., Zuffardi, O., Castaldo, P., Taglialatela, M., Andria, G., Sebastio, G. Genomics (1998) [Pubmed]
  6. Development and polarization of cationic amino acid transporters and regulators in the human placenta. Ayuk, P.T., Sibley, C.P., Donnai, P., D'Souza, S., Glazier, J.D. Am. J. Physiol., Cell Physiol. (2000) [Pubmed]
  7. Binding of tetrodotoxin and saxitoxin to Na+ channels at different holding potentials: fluctuation measurements in frog myelinated nerve. Lönnendonker, U. Biochim. Biophys. Acta (1989) [Pubmed]
  8. Human IgA- and IgM-secreting intestinal plasma cells carry heavily mutated VH region genes. Fischer, M., Küppers, R. Eur. J. Immunol. (1998) [Pubmed]
  9. Procaine incorporation into human erythrocyte membrane--a spin label study. Mihailescu, D., Constantinescu, A., Dragutan, I., Cuculescu, M., Frangopol, P.T. Archives internationales de physiologie, de biochimie et de biophysique. (1993) [Pubmed]
  10. Endogenous cortisol level interacts with noradrenergic activation in the human amygdala. van Stegeren, A.H., Wolf, O.T., Everaerd, W., Scheltens, P., Barkhof, F., Rombouts, S.A. Neurobiology of learning and memory (2007) [Pubmed]
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