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Gene Review

Slc7a2  -  solute carrier family 7 (cationic amino...

Mus musculus

Synonyms: 20.5, AI158848, Atrc2, CAT-2, CAT2, ...
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Disease relevance of Slc7a2

  • CAT-2 expression was observed in hepatocytes in vitro and in vivo, consistent with reports of infection of regenerating and cultured hepatocytes by amphotropic retroviruses [1].
  • Marked eosinophilia, associated with up-regulation of eotaxin-1, was present in the bronchoalveolar lavage fluid of 3-week-old CAT2-deficient mice [2].
  • The prevention of lung cancer induced by a tobacco-specific carcinogen in rodents by green and black Tea [3].
  • Oxcarbazepine (OCBZ, Trileptal) and its main human monohydroxy metabolite (MHD) protected mice and rats against generalized tonic-clonic seizures induced by electroshock with ED50 values between 13.5 and 20.5 mg/kg p.o. No tolerance toward this anticonvulsant effect was observed when rats were treated with OCBZ or MHD daily for 4 weeks [4].
  • Similarly, the Ca(2+)-regulated K(+) channel blockers, BaCl(2) and quinidine, decreased the K(+) current by 20.5 +/- 1.0% and 36.6 +/- 1.2%, respectively, and slowed migration of B-16 melanoma cells by 37.1 +/- 8.6% and 42.7 +/- 8.8%, respectively [5].

Psychiatry related information on Slc7a2


High impact information on Slc7a2

  • Thus, our data suggest that CAT2 regulates anti-inflammatory processes in the lungs via regulation of dendritic cell activation and subsequent T cell responses [2].
  • Despite the presence of activated alveolar macrophages in CAT2-deficient mice, NO production was compromised in these cells [2].
  • The Tea gene is distinct from, but bears extensive amino acid and DNA sequence similarity with, the murine ecotropic retroviral receptor which is encoded by the Rec-1 gene [8].
  • The gene was expressed on concanavalin A-activated T lymphocytes and was designated Tea (T-cell early activation gene) [8].
  • The Tea gene mapped to chromosome 8 and appeared to be conserved among mammalian and avian species [8].

Chemical compound and disease context of Slc7a2


Biological context of Slc7a2

  • Although the amino acid sequences of the isoforms differ in only 21 of 43 residues with the majority of substitutions being conservative, the apparent affinity of CAT2 beta for arginine uptake was 70-fold higher than the CAT2 alpha isoform (Km 38 microM versus 2.7 mM) [10].
  • No change in promoter usage was apparent under any stress conditions tested nor was alternate splicing of the CAT2 transcript dictated by promoter usage [6].
  • IL-10 also attenuated the LPS-induced upregulation of CAT-2 mRNA [11].
  • In contrast, mRNA for the cationic amino acid transporter, CAT2, was induced by plasmid DNA alone, and priming with IFN-gamma had no effect on this response [12].
  • After subtraction of the zero-time values, the initial rates of influx for VM-26 (extracellular concentration, 20.5 microM) and the apparent equilibrium constants for the flux of drug across the cell membrane correlated inversely with the logarithm of the IC50 values [13].

Anatomical context of Slc7a2

  • The expression of CAT2/2a transcripts was tested in skeletal muscle and macrophages following specific stresses or activators [6].
  • In macrophages, liver and skeletal muscle, the most distal CAT2 promoter was predominant [6].
  • Here we report that iNOS activity is impaired by 84% in activated Cat2-deficient astrocytes [14].
  • We report an extended and corrected Tea cDNA sequence and show that the mammalian Tea and ERR encoding genes are differentially expressed in tissues and cell lines [15].
  • When the dorsal skins of 8.5-, 20.5-, and 60.5-day-old mice were wounded, the increase in the melanocyte and melanoblast-melanocyte populations was much smaller than the newborn mice [16].

Associations of Slc7a2 with chemical compounds

  • The effects of lidocaine on CAT-2 and GTPCH are unknown [17].
  • Chimeric mice with TNF-deficient leukocytes but intact intrinsic renal cell-derived TNF (crescents, 20.5 +/- 2.0% of glomeruli; serum creatinine, 21.6 +/- 1.4 micromol/L) developed similar crescentic GN to WT mice (crescents, 22.3 +/- 1.4% of glomeruli; serum creatinine, 24.8 +/- 1.9 micromol/L) [18].
  • An increase in malondialdehyde content (nmol microg of protein(-1)), especially at high CdCl(2) concentrations (control = 7.3 +/- 0.5; CdCl(2): 7.5 microM = 11.2 +/- 3.1, 10 microM = 14.6 +/- 3.8, and 12.5 microM = 20.5 +/- 6.5) indicated that there was enhanced lipid peroxidation [19].
  • In these neuronal hybrids, we have found that bradykinin induces sequential elevation in the concentrations of several second messengers involved in neuronal activation, including inositol trisphosphate (6.5-fold), intracellular calcium (2.7-fold), and cyclic GMP (20.5-fold) [20].
  • Isop significantly increased androgen production by 20.5-day rat and 17.5-day mouse fetuses after a time lag of 30 and 180 min, respectively [21].

Other interactions of Slc7a2

  • The increase in arginine transport during activation, but not proliferation, was mediated by the SLC7A2/Cat2 gene [22].
  • Our results support the idea that manipulation of CAT2 transporter function might be useful for the therapeutic modulation of iNOS activity [14].
  • These results suggest that NO is produced in the mouse lung in response to F. kyushuense exposure and that the NO production is regulated by CAT2, the citrulline-NO cycle, and arginase isoforms [23].
  • Recently, it has been suggested that CAT-2 may be a receptor for amphotropic murine leukemia virus [1].

Analytical, diagnostic and therapeutic context of Slc7a2

  • In situ hybridization on brain sections revealed that CAT3 transcripts were localized predominantly along the midbrain-thalamus-hypothalamus axis, whereas neither CAT1 nor CAT2 transcripts demonstrated a similar localization [24].
  • In addition, mRNA encoding the cationic amino acid transporter-2 (CAT-2) was strongly induced shortly after treatment [25].
  • Immunoprecipitation and SDS-PAGE analysis identified 20.5- and 18-kDa proteins with mAb H1-229 or H2-439, respectively, in cellular extracts of 125I-surface labeled NS-1 transfected with the corresponding genes [26].
  • Western blot analysis, using an anti-rodent bFGF antibody, shows multiple molecular weights of 18, 20.5, and 22 kDa of bFGF protein isolated from the adult retina [27].
  • Analysis of these conjugates by high performance liquid chromatography revealed a major peak eluting at 20.5 min [28].


  1. Retroviral infection and expression of cationic amino acid transporters in rodent hepatocytes. Closs, E.I., Borel Rinkes, I.H., Bader, A., Yarmush, M.L., Cunningham, J.M. J. Virol. (1993) [Pubmed]
  2. Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung. Rothenberg, M.E., Doepker, M.P., Lewkowich, I.P., Chiaramonte, M.G., Stringer, K.F., Finkelman, F.D., Macleod, C.L., Ellies, L.G., Zimmermann, N. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. The prevention of lung cancer induced by a tobacco-specific carcinogen in rodents by green and black Tea. Chung, F.L. Proc. Soc. Exp. Biol. Med. (1999) [Pubmed]
  4. Oxcarbazepine: preclinical anticonvulsant profile and putative mechanisms of action. Schmutz, M., Brugger, F., Gentsch, C., McLean, M.J., Olpe, H.R. Epilepsia (1994) [Pubmed]
  5. ET-1 inhibits B-16 murine melanoma cell migration by decreasing K(+) currents. Liu, L.Y., Hu, C.L., Ma, L.J., Zhang, Z.H., Mei, Y.A. Cell Motil. Cytoskeleton (2004) [Pubmed]
  6. Stress differentially induces cationic amino acid transporter gene expression. Kakuda, D.K., Finley, K.D., Maruyama, M., MacLeod, C.L. Biochim. Biophys. Acta (1998) [Pubmed]
  7. Sleep-time variation for ethanol and the hypnotic drugs tribromoethanol, urethane, pentobarbital, and propofol within outbred ICR mice. Koizumi, T., Maeda, H., Hioki, K. Exp. Anim. (2002) [Pubmed]
  8. Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor. MacLeod, C.L., Finley, K., Kakuda, D., Kozak, C.A., Wilkinson, M.F. Mol. Cell. Biol. (1990) [Pubmed]
  9. Effect of Ascorbic Acid, Lysine, Proline, and Green Tea Extract on Human Osteosarcoma Cell Line MNNG-HOS Xenografts in Nude Mice: Evaluation of Tumor Growth and Immunohistochemistry. Roomi, M.W., Ivanov, V., Kalinovsky, T., Niedzwiecki, A., Rath, M. Med. Oncol. (2006) [Pubmed]
  10. Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family. Kavanaugh, M.P., Wang, H., Zhang, Z., Zhang, W., Wu, Y.N., Dechant, E., North, R.A., Kabat, D. J. Biol. Chem. (1994) [Pubmed]
  11. Interleukin-10 inhibition of nitric oxide biosynthesis involves suppression of CAT-2 transcription. Huang, C.J., Stevens, B.R., Nielsen, R.B., Slovin, P.N., Fang, X., Nelson, D.R., Skimming, J.W. Nitric Oxide (2002) [Pubmed]
  12. IFN-gamma primes macrophage responses to bacterial DNA. Sweet, M.J., Stacey, K.J., Kakuda, D.K., Markovich, D., Hume, D.A. J. Interferon Cytokine Res. (1998) [Pubmed]
  13. Flux of teniposide (VM-26) across the plasma membrane of teniposide-resistant sublines of L1210 cells. Lee, T., Roberts, D. Cancer Res. (1984) [Pubmed]
  14. CAT2 arginine transporter deficiency significantly reduces iNOS-mediated NO production in astrocytes. Manner, C.K., Nicholson, B., MacLeod, C.L. J. Neurochem. (2003) [Pubmed]
  15. Mammalian integral membrane receptors are homologous to facilitators and antiporters of yeast, fungi, and eubacteria. Reizer, J., Finley, K., Kakuda, D., MacLeod, C.L., Reizer, A., Saier, M.H. Protein Sci. (1993) [Pubmed]
  16. Developmental changes of the proliferative response of mouse epidermal melanocytes to skin wounding. Hirobe, T. Development (1988) [Pubmed]
  17. Lidocaine inhibition of inducible nitric oxide synthase and cationic amino acid transporter-2 transcription in activated murine macrophages may involve voltage-sensitive Na+ channel. Huang, Y.H., Tsai, P.S., Kai, Y.F., Yang, C.H., Huang, C.J. Anesth. Analg. (2006) [Pubmed]
  18. Intrinsic renal cells are the major source of tumor necrosis factor contributing to renal injury in murine crescentic glomerulonephritis. Timoshanko, J.R., Sedgwick, J.D., Holdsworth, S.R., Tipping, P.G. J. Am. Soc. Nephrol. (2003) [Pubmed]
  19. Cadmium chloride-induced oxidative stress in skeletal muscle cells in vitro. Yano, C.L., Marcondes, M.C. Free Radic. Biol. Med. (2005) [Pubmed]
  20. Bradykinin analogs antagonize bradykinin-induced second messenger production in a sensory neuron cell line. Francel, P.C., Keefer, J.F., Dawson, G. Mol. Pharmacol. (1989) [Pubmed]
  21. Ontogeny of rodent testicular androgen production in response to isoproterenol and luteinizing hormone in vitro. Anakwe, O.O., Moger, W.H. Biol. Reprod. (1984) [Pubmed]
  22. Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation. Yeramian, A., Martin, L., Arpa, L., Bertran, J., Soler, C., McLeod, C., Modolell, M., Palacín, M., Lloberas, J., Celada, A. Eur. J. Immunol. (2006) [Pubmed]
  23. Expression of inducible nitric oxide synthase and enzymes of arginine metabolism in Fusarium kyushuense-exposed mouse lung. Mahmoud, Y.A., Harada, K., Nagasaki, A., Gotoh, T., Takeya, M., Salimuddin, n.u.l.l., Ueda, A., Mori, M. Nitric Oxide (1999) [Pubmed]
  24. A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain. Ito, K., Groudine, M. J. Biol. Chem. (1997) [Pubmed]
  25. Co-induction of argininosuccinate synthetase, cationic amino acid transporter-2, and nitric oxide synthase in activated murine microglial cells. Kawahara, K., Gotoh, T., Oyadomari, S., Kajizono, M., Kuniyasu, A., Ohsawa, K., Imai, Y., Kohsaka, S., Nakayama, H., Mori, M. Brain Res. Mol. Brain Res. (2001) [Pubmed]
  26. Expression of nm23/NDP kinase proteins on the cell surface. Urano, T., Furukawa, K., Shiku, H. Oncogene (1993) [Pubmed]
  27. Basic fibroblast growth factor in retinal development: differential levels of bFGF expression and content in normal and retinal degeneration (rd) mutant mice. Gao, H., Hollyfield, J.G. Dev. Biol. (1995) [Pubmed]
  28. Epoxide formation from diallyl sulfone is associated with CYP2E1 inactivation in murine and human lungs. Forkert, P.G., Premdas, P.D., Bowers, R.J. Am. J. Respir. Cell Mol. Biol. (2000) [Pubmed]
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