The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

LOC654342  -  lymphocyte-specific protein 1 pseudogene

Homo sapiens

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LOC654342

  • This study examines LSP1-deficient (Lsp1(-/-)) mice for the development of myeloid and lymphocytic cell populations and their response to the development of peritonitis induced by thioglycollate (TG) and to a T-dependent antigen [1].

High impact information on LOC654342


Biological context of LOC654342

  • Errors in the repair of both general and lymphocyte-specific DSBs can lead to oncogenic chromosomal translocations . Here, we review recent advances in understanding factors and protein complexes involved in the response to DNA DSBs with a focus on the B lymphocyte specific process of CSR [3].
  • On injection of TG, the Lsp1(-/-) mice exhibit an accelerated kinetics of changes in peritoneal macrophage and neutrophil numbers as compared to wt including increased influx of these cells [1].
  • In this study, we have analyzed gammadelta thymocyte subsets with respect to behavior during cultivation, cell cycle status, and lymphocyte-specific transcripts [4].
  • Inhibition of HDAC activity during reprogramming selectively blocks the silencing of lymphocyte-specific genes but does not prevent the establishment of muscle-specific gene expression [5].

Anatomical context of LOC654342


Associations of LOC654342 with chemical compounds

  • Development of N-4,6-pyrimidine-N-alkyl-N'-phenyl ureas as orally active inhibitors of lymphocyte specific tyrosine kinase [7].

Analytical, diagnostic and therapeutic context of LOC654342


  1. LSP1 modulates leukocyte populations in resting and inflamed peritoneum. Jongstra-Bilen, J., Misener, V.L., Wang, C., Ginzberg, H., Auerbach, A., Joyner, A.L., Downey, G.P., Jongstra, J. Blood (2000) [Pubmed]
  2. Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. Espert, L., Denizot, M., Grimaldi, M., Robert-Hebmann, V., Gay, B., Varbanov, M., Codogno, P., Biard-Piechaczyk, M. J. Clin. Invest. (2006) [Pubmed]
  3. Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations. Franco, S., Alt, F.W., Manis, J.P. DNA Repair (Amst.) (2006) [Pubmed]
  4. Two Groups of Porcine TCR{gamma}{delta}+ Thymocytes Behave and Diverge Differently. Sinkora, M., Sinkorov??, J., Cimburek, Z., Holtmeier, W. J. Immunol. (2007) [Pubmed]
  5. Acquisition and extinction of gene expression programs are separable events in heterokaryon reprogramming. Terranova, R., Pereira, C.F., Du Roure, C., Merkenschlager, M., Fisher, A.G. J. Cell. Sci. (2006) [Pubmed]
  6. Leukocyte-Specific Protein 1 (LSP1): A Regulator of Leukocyte Emigration in Inflammation. Jongstra-Bilen, J., Jongstra, J. Immunol. Res. (2006) [Pubmed]
  7. Development of N-4,6-pyrimidine-N-alkyl-N'-phenyl ureas as orally active inhibitors of lymphocyte specific tyrosine kinase. Maier, J.A., Brugel, T.A., Sabat, M., Golebiowski, A., Laufersweiler, M.J., VanRens, J.C., Hopkins, C.R., De, B., Hsieh, L.C., Brown, K.K., Easwaran, V., Janusz, M.J. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
  8. Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen. Kadiyala, R.K., McIntyre, B.W., Krensky, A.M. Eur. J. Immunol. (1990) [Pubmed]
WikiGenes - Universities