High impact information on 1700021K02Rik

• CaMKII Activation in the Entorhinal Cortex Disrupts Previously Encoded Spatial Memory [1].
• Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors [2].
• These data suggest that a normal three-dimensional organization of stromal cells is required for Spatial expression [3].
• In frozen thymus sections, subcapsular epithelial cells were stained with the anti-Spatial antiserum [3].
• Temporal and Spatial Disparity in cFOS Expression and Dopamine Phenotypic Differentiation in the Neonatal Mouse Olfactory Bulb [4].

Biological context of 1700021K02Rik

• In the testis, the Spatial gene is also expressed by round spermatids during spermatogenesis [5].
• Genomic organization and the tissue distribution of alternatively spliced isoforms of the mouse Spatial gene [5].
• RESULTS: The Spatial gene maps to the B3-B4 region of murine chromosome 10 corresponding to the human syntenic region 10q22 [5].
• Analysis of purified testicular cell types show that Spatial expression is restricted to haploid round spermatids during spermiogenesis and the expression sites were further localized by in situ hybridization to step 2-10 spermatids [6].
• 1. The mouse Spatial genomic DNA is organised into 10 exons and is alternatively spliced to generate two short isoforms (Spatial-alpha and -gamma) and two other long isoforms (Spatial-delta and -epsilon) comprising 5 additional exons on the 3' site [5].

Anatomical context of 1700021K02Rik

• We report here, by RT-PCR on 48 distinct tissues that Spatial is also highly expressed in testis [6].
• The "Stromal Protein Associated with Thymii And Lymph-node" (Spatial) gene encodes a putative transcription factor which may be involved in T-cell development [5].

Associations of 1700021K02Rik with chemical compounds

• We further examined the inter-species conservation of Spatial between several mammals and identified that the protein which is rich in proline and positive amino acids, is highly conserved [5].

Other interactions of 1700021K02Rik

• 5. Spatial distributions of RARbeta and RARgamma were examined in RA-treated and Sp mutant embryos by in situ hybridization [7].

References