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Gene Review

KLC1  -  kinesin light chain 1

Homo sapiens

Synonyms: KLC, KLC 1, KNS2, KNS2A, Kinesin light chain 1, ...
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Disease relevance of KLC1


Psychiatry related information on KLC1


High impact information on KLC1

  • Coimmunoprecipitation, sucrose gradient, and direct in vitro binding demonstrated that APP forms a complex with the microtubule motor, conventional kinesin (kinesin-I), by binding directly to the TPR domain of the kinesin light chain (KLC) subunit [6].
  • Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I [6].
  • In addition, in the inactive state, the KHC motor domains are pushed apart by the KLC subunit [7].
  • We show here that Alcalpha strongly associates with kinesin light chain (K(D) approximately 4-8 x 10(-9) M) through a novel tryptophan- and aspartic acid-containing sequence [8].
  • Inactivation of kinesin, hyperphosphorylation of kinesin light chain, and perinuclear clustering of mitochondria exhibit the same p38 mitogen-activated kinase dependence, indicating their functional relationship [5].

Biological context of KLC1


Anatomical context of KLC1


Associations of KLC1 with chemical compounds

  • The phosphotyrosine binding domain of JIP1 binds the cytoplasmic tail of AbetaPP, whereas the JIP1 C-terminal region interacts with the tetratrico-peptide repeats of Klc1 [12].
  • The interaction of HAP1 with kinesin light chain is demonstrated via a yeast two-hybrid assay, glutathione S-transferase pull down, and coimmunoprecipitation [16].
  • In the presence of citrate, this step is followed by formation of an intermediate complex with monoferric ovotransferrin; stability constant KLC = (0.435 +/- 0.015) mM [17].
  • We describe a patient with KLC who had the typical features of this disease and responded partially to treatment with oral isotretinoin [18].
  • We describe a 35-year-old woman with KLC who had the typical features of widespread violaceous, reticulate, and striae-like eruptions with a prominent keratotic component over a nine-year period and who responded well to treatment with calcipotriol ointment [19].

Physical interactions of KLC1


Other interactions of KLC1


Analytical, diagnostic and therapeutic context of KLC1


  1. Polycystin-2 Cation Channel Function Is under the Control of Microtubular Structures in Primary Cilia of Renal Epithelial Cells. Li, Q., Montalbetti, N., Wu, Y., Ramos, A., Raychowdhury, M.K., Chen, X.Z., Cantiello, H.F. J. Biol. Chem. (2006) [Pubmed]
  2. Association of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptides. Benboudjema, L., Mulvey, M., Gao, Y., Pimplikar, S.W., Mohr, I. J. Virol. (2003) [Pubmed]
  3. Kinesin light chain in a eubacterium. Celerin, M., Gilpin, A.A., Dossantos, G., Laudenbach, D.E., Clarke, M.W., Beushausen, S. DNA Cell Biol. (1997) [Pubmed]
  4. Association study of three polymorphisms of kinesin light-chain 1 gene with Alzheimer's disease. Dhaenens, C.M., Van Brussel, E., Schraen-Maschke, S., Pasquier, F., Delacourte, A., Sablonnière, B. Neurosci. Lett. (2004) [Pubmed]
  5. Tumor necrosis factor induces hyperphosphorylation of kinesin light chain and inhibits kinesin-mediated transport of mitochondria. De Vos, K., Severin, F., Van Herreweghe, F., Vancompernolle, K., Goossens, V., Hyman, A., Grooten, J. J. Cell Biol. (2000) [Pubmed]
  6. Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Kamal, A., Stokin, G.B., Yang, Z., Xia, C.H., Goldstein, L.S. Neuron (2000) [Pubmed]
  7. Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cells. Cai, D., Hoppe, A.D., Swanson, J.A., Verhey, K.J. J. Cell Biol. (2007) [Pubmed]
  8. The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. Araki, Y., Kawano, T., Taru, H., Saito, Y., Wada, S., Miyamoto, K., Kobayashi, H., Ishikawa, H.O., Ohsugi, Y., Yamamoto, T., Matsuno, K., Kinjo, M., Suzuki, T. EMBO J. (2007) [Pubmed]
  9. The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23. Diefenbach, R.J., Diefenbach, E., Douglas, M.W., Cunningham, A.L. Biochemistry (2002) [Pubmed]
  10. A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. Inomata, H., Nakamura, Y., Hayakawa, A., Takata, H., Suzuki, T., Miyazawa, K., Kitamura, N. J. Biol. Chem. (2003) [Pubmed]
  11. Alternatively spliced products of the human kinesin light chain 1 (KNS2) gene. McCart, A.E., Mahony, D., Rothnagel, J.A. Traffic (2003) [Pubmed]
  12. Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1. Matsuda, S., Matsuda, Y., D'Adamio, L. J. Biol. Chem. (2003) [Pubmed]
  13. Light chain-dependent regulation of Kinesin's interaction with microtubules. Verhey, K.J., Lizotte, D.L., Abramson, T., Barenboim, L., Schnapp, B.J., Rapoport, T.A. J. Cell Biol. (1998) [Pubmed]
  14. The early onset dystonia protein torsinA interacts with kinesin light chain 1. Kamm, C., Boston, H., Hewett, J., Wilbur, J., Corey, D.P., Hanson, P.I., Ramesh, V., Breakefield, X.O. J. Biol. Chem. (2004) [Pubmed]
  15. Analysis of Kinesin-2 Function in Photoreceptor Cells Using Synchronous Cre-loxP Knockout of Kif3a with RHO-Cre. Jimeno, D., Feiner, L., Lillo, C., Teofilo, K., Goldstein, L.S., Pierce, E.A., Williams, D.S. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  16. Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons. McGuire, J.R., Rong, J., Li, S.H., Li, X.J. J. Biol. Chem. (2006) [Pubmed]
  17. Transferrins, the mechanism of iron release by ovotransferrin. Abdallah, F.B., Chahine, J.M. Eur. J. Biochem. (1999) [Pubmed]
  18. Keratosis lichenoides chronica. Konstantinov, K.N., Søndergaard, J., Izuno, G., Obreshkova, E. J. Am. Acad. Dermatol. (1998) [Pubmed]
  19. Keratosis lichenoides chronica: marked response to calcipotriol ointment. Chang, S.E., Jung, E.C., Hong, S.M., Choi, J.H., Sung, K.J., Moon, K.C., Koh, J.K. J. Dermatol. (2000) [Pubmed]
  20. Mapping the GRIF-1 Binding Domain of the Kinesin, KIF5C, Substantiates a Role for GRIF-1 as an Adaptor Protein in the Anterograde Trafficking of Cargoes. Smith, M.J., Pozo, K., Brickley, K., Stephenson, F.A. J. Biol. Chem. (2006) [Pubmed]
  21. PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. Zheng, P., Eastman, J., Vande Pol, S., Pimplikar, S.W. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  22. Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins. Rahman, A., Friedman, D.S., Goldstein, L.S. J. Biol. Chem. (1998) [Pubmed]
  23. Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics. Hewett, J.W., Zeng, J., Niland, B.P., Bragg, D.C., Breakefield, X.O. Neurobiol. Dis. (2006) [Pubmed]
  24. Localization of the human kinesin light chain gene (KNS2) to chromosome 14q32.3 by fluorescence in situ hybridization. Goedert, M., Marsh, S., Carter, N. Genomics (1996) [Pubmed]
  25. A specific light chain of kinesin associates with mitochondria in cultured cells. Khodjakov, A., Lizunova, E.M., Minin, A.A., Koonce, M.P., Gyoeva, F.K. Mol. Biol. Cell (1998) [Pubmed]
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