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Gene Review

Fgf1  -  fibroblast growth factor 1 (acidic)

Rattus norvegicus

Synonyms: Acidic fibroblast growth factor, FGF-1, Fgf-1, Fgfa, Fibroblast growth factor 1, ...
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Disease relevance of Fgf1


Psychiatry related information on Fgf1


High impact information on Fgf1


Chemical compound and disease context of Fgf1


Biological context of Fgf1


Anatomical context of Fgf1


Associations of Fgf1 with chemical compounds

  • Immunoblotting of crude and heparin-bound embryo extracts revealed faint bands at the expected 17-18-kD and predominant bands at an apparent molecular mass of 26 to 28-kD (despite reducing conditions) using multiple specific antibodies for aFGF and bFGF [19].
  • Pretreatment with 8 M urea yielded 18-20-kD aFGF and bFGF and some 24-26-kD bFGF [19].
  • The addition of bFGF or aFGF in serum-free medium to pure populations of myocytes (after 10 days in culture, at which time they are spread, beating, and multinucleated) led to increased thymidine incorporation [21].
  • In contrast, C3, D1, T1, or T5 cell-secreted mitogens enhanced proliferation of T1 and T5 cells, and proliferation of D1, T1, and T5 cells was enhanced by bFGF, aFGF, and EGF [1].
  • FGF-1 induced the expression of HO-1 in cultured rat spinal cord astrocytes, which was dependent on FGF receptor activation and prevented by cycloheximide [25].

Physical interactions of Fgf1


Enzymatic interactions of Fgf1


Regulatory relationships of Fgf1


Other interactions of Fgf1

  • The immunostaining patterns were very similar for aFGF and bFGF for each organ and at each stage [19].
  • Unlike FGF-2, the distribution of FGFR1 mRNA correlates well with the presence of the immunoreactive receptor [38].
  • Astroglial cells from all brain regions showed a slight FGF-mediated increase in 5-bromo-2'-desoxy-uridine (BrdU) incorporation, which was abolished upon co-treatment with TGF-beta3 [39].
  • Transforming growth factor-beta 1 (TGF-beta 1), which inhibits some effects of FGFs, increased NGF synthesis in concert with aFGF [40].
  • Here, we examined whether fibronectin (FN) and FGF can cooperate for neuronal adhesion and neurite outgrowth [41].

Analytical, diagnostic and therapeutic context of Fgf1


  1. Differences in responsiveness of clonally derived AXC/SSh rat prostate cancer cells to secreted or prototypic mitogens. Shain, S.A., Koger, J.D. Cancer Res. (1989) [Pubmed]
  2. Pertussis toxin-sensitive G-proteins inhibit fibroblast growth factor-induced signaling in pancreatic acini. Piiper, A., Stryjek-Kaminska, D., Gebhardt, R., Zeuzem, S. J. Cell. Physiol. (1996) [Pubmed]
  3. Protection of rat myocardium by mitogenic and non-mitogenic fibroblast growth factor during post-ischemic reperfusion. Cuevas, P., Carceller, F., Lozano, R.M., Crespo, A., Zazo, M., Giménez-Gallego, G. Growth Factors (1997) [Pubmed]
  4. Acidic fibroblast growth factor activates adrenomedullary secretion and sympathetic outflow in rats. Matsumoto, I., Niijima, A., Oomura, Y., Sasaki, K., Tsuchiya, K., Aikawa, T. Am. J. Physiol. (1998) [Pubmed]
  5. Regulation of astrocyte proliferation by FGF-2 and heparan sulfate in vivo. Gómez-Pinilla, F., Vu, L., Cotman, C.W. J. Neurosci. (1995) [Pubmed]
  6. Spatial learning and physical activity contribute to the induction of fibroblast growth factor: neural substrates for increased cognition associated with exercise. Gómez-Pinilla, F., So, V., Kesslak, J.P. Neuroscience (1998) [Pubmed]
  7. Sleep deprivation effects on growth factor expression in neonatal rats: a potential role for BDNF in the mediation of delta power. Hairston, I.S., Peyron, C., Denning, D.P., Ruby, N.F., Flores, J., Sapolsky, R.M., Heller, H.C., O'Hara, B.F. J. Neurophysiol. (2004) [Pubmed]
  8. Fibroblast growth factor inhibits locomotor activity as well as feeding behavior of rats. Hotta, M., Kuriyama, H., Arai, K., Takano, K., Shibasaki, T. Eur. J. Pharmacol. (2001) [Pubmed]
  9. The fibroblast growth factor system and mood disorders. Turner, C.A., Akil, H., Watson, S.J., Evans, S.J. Biol. Psychiatry (2006) [Pubmed]
  10. Enhancement of slow wave sleep parallel to the satiating effect of acidic fibroblast growth factor in rats. De Saint Hilaire, Z., Nicolaïdis, S. Brain Res. Bull. (1992) [Pubmed]
  11. Structure of a heparin-linked biologically active dimer of fibroblast growth factor. DiGabriele, A.D., Lax, I., Chen, D.I., Svahn, C.M., Jaye, M., Schlessinger, J., Hendrickson, W.A. Nature (1998) [Pubmed]
  12. Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis. Peters, K.G., Marie, J., Wilson, E., Ives, H.E., Escobedo, J., Del Rosario, M., Mirda, D., Williams, L.T. Nature (1992) [Pubmed]
  13. Activin is a nerve cell survival molecule. Schubert, D., Kimura, H., LaCorbiere, M., Vaughan, J., Karr, D., Fischer, W.H. Nature (1990) [Pubmed]
  14. Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo. Anderson, K.J., Dam, D., Lee, S., Cotman, C.W. Nature (1988) [Pubmed]
  15. Neither fibroblast growth factor-1 nor fibroblast growth factor-2 is an androgen receptor coactivator in androgen-resistant prostate cancer. Shain, S.A. Molecular urology. (2001) [Pubmed]
  16. Brain-derived neurotrophic factor and basic fibroblast growth factor downregulate NMDA receptor function in cerebellar granule cells. Brandoli, C., Sanna, A., De Bernardi, M.A., Follesa, P., Brooker, G., Mocchetti, I. J. Neurosci. (1998) [Pubmed]
  17. Immunolocalization of heparin-binding growth factors (HBGF) types 1 and 2 in rat liver. Selective hyperexpression of HBGF-2 in carbon tetrachloride-induced fibrosis. Charlotte, F., Win, K.M., Preaux, A.M., Mavier, P., Dhumeaux, D., Zafrani, E.S., Rosenbaum, J. J. Pathol. (1993) [Pubmed]
  18. Fibroblast growth factor-induced increases in calcium currents in the PC12 pheochromocytoma cell line are tyrosine phosphorylation dependent. Rane, S.G., Pollock, J.D. J. Neurosci. Res. (1994) [Pubmed]
  19. Acidic fibroblast growth factor in the developing rat embryo. Fu, Y.M., Spirito, P., Yu, Z.X., Biro, S., Sasse, J., Lei, J., Ferrans, V.J., Epstein, S.E., Casscells, W. J. Cell Biol. (1991) [Pubmed]
  20. Differential regulation of acidic and basic fibroblast growth factor gene expression in fibroblast growth factor-treated rat aortic smooth muscle cells. Alberts, G.F., Hsu, D.K., Peifley, K.A., Winkles, J.A. Circ. Res. (1994) [Pubmed]
  21. Acidic and basic fibroblast growth factors in adult rat heart myocytes. Localization, regulation in culture, and effects on DNA synthesis. Speir, E., Tanner, V., Gonzalez, A.M., Farris, J., Baird, A., Casscells, W. Circ. Res. (1992) [Pubmed]
  22. Interaction of heparan sulfate from mammary cells with acidic fibroblast growth factor (FGF) and basic FGF. Regulation of the activity of basic FGF by high and low affinity binding sites in heparan sulfate. Rahmoune, H., Chen, H.L., Gallagher, J.T., Rudland, P.S., Fernig, D.G. J. Biol. Chem. (1998) [Pubmed]
  23. The nucleotide sequence of rat heparin binding growth factor 1 (HBGF-1). Goodrich, S.P., Yan, G.C., Bahrenburg, K., Mansson, P.E. Nucleic Acids Res. (1989) [Pubmed]
  24. Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture. Lipton, S.A., Wagner, J.A., Madison, R.D., D'Amore, P.A. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  25. Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: consequences for motor neuron survival. Vargas, M.R., Pehar, M., Cassina, P., Martínez-Palma, L., Thompson, J.A., Beckman, J.S., Barbeito, L. J. Biol. Chem. (2005) [Pubmed]
  26. Intracellular trafficking in neurones and glia of fibroblast growth factor-2, fibroblast growth factor receptor 1 and heparan sulphate proteoglycans in the injured adult rat cerebral cortex. Leadbeater, W.E., Gonzalez, A.M., Logaras, N., Berry, M., Turnbull, J.E., Logan, A. J. Neurochem. (2006) [Pubmed]
  27. Synergistic interaction of interleukin-1 beta and growth factors in primary cultures of rat aortic smooth muscle cells. Bourcier, T., Dockter, M., Hassid, A. J. Cell. Physiol. (1995) [Pubmed]
  28. Heparin modulation of the neurotropic effects of acidic and basic fibroblast growth factors and nerve growth factor on PC12 cells. Neufeld, G., Gospodarowicz, D., Dodge, L., Fujii, D.K. J. Cell. Physiol. (1987) [Pubmed]
  29. Trk receptor binding and neurotrophin/fibroblast growth factor (FGF)-dependent activation of the FGF receptor substrate (FRS)-3. Dixon, S.J., MacDonald, J.I., Robinson, K.N., Kubu, C.J., Meakin, S.O. Biochim. Biophys. Acta (2006) [Pubmed]
  30. Cloning, functional expression and role in cell growth regulation of a hamster 5-HT2 receptor subtype. Van Obberghen-Schilling, E., Vouret-Craviari, V., Haslam, R.J., Chambard, J.C., Pouysségur, J. Mol. Endocrinol. (1991) [Pubmed]
  31. Identification of a 79-kDa heparin-binding fibroblast growth factor (FGF) receptor in rat hepatocytes and its correlation with the different growth responses to FGF-1 between hepatocyte subpopulations. Tanahashi, T., Suzuki, M., Imamura, T., Mitsui, Y. J. Biol. Chem. (1996) [Pubmed]
  32. Nerve growth factor and fibroblast growth factor selectively activate a protein kinase that phosphorylates high molecular weight microtubule-associated proteins. Detection, partial purification, and characterization in PC12 cells. Tsao, H., Aletta, J.M., Greene, L.A. J. Biol. Chem. (1990) [Pubmed]
  33. Basic fibroblast growth factor and N-cadherin maintain rat granulosa cell and ovarian surface epithelial cell viability by stimulating the tyrosine phosphorylation of the fibroblast growth factor receptors. Trolice, M.P., Pappalardo, A., Peluso, J.J. Endocrinology (1997) [Pubmed]
  34. Fibroblast growth factor 2 increases Otx2 expression in precursor cells from mammalian telencephalon. Robel, L., Ding, M., James, A.J., Lin, X., Simeone, A., Leckman, J.F., Vaccarino, F.M. J. Neurosci. (1995) [Pubmed]
  35. Alternate FGF2-ERK1/2 signaling pathways in retinal photoreceptor and glial cells in vitro. Kinkl, N., Sahel, J., Hicks, D. J. Biol. Chem. (2001) [Pubmed]
  36. Growth hormone-releasing factor and fibroblast growth factor regulate somatostatin gene expression. Zeytin, F.N., Rusk, S.F., De Lellis, R. Endocrinology (1988) [Pubmed]
  37. Expression of the fibroblast growth factor receptor 1-4 genes in glomeruli in anti-Thy1.1 mesangial proliferative glomerulonephritis. Jyo-Oshiro, Y., Sasaki, T., Kawakami, Y., Nohno, T., Itoh, N., Osawa, G., Kashihara, N. Virchows Arch. (1999) [Pubmed]
  38. Fibroblast growth factor in the hypothalamic-pituitary axis: differential expression of fibroblast growth factor-2 and a high affinity receptor. Gonzalez, A.M., Logan, A., Ying, W., Lappi, D.A., Berry, M., Baird, A. Endocrinology (1994) [Pubmed]
  39. Fibroblast growth factor 2 (FGF-2) differentially regulates connexin (cx) 43 expression and function in astroglial cells from distinct brain regions. Reuss, B., Dermietzel, R., Unsicker, K. Glia (1998) [Pubmed]
  40. Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines. Yoshida, K., Gage, F.H. Brain Res. (1992) [Pubmed]
  41. Synergistic activity of fibronectin and fibroblast growth factor receptors on neuronal adhesion and neurite extension through extracellular signal-regulated kinase pathway. Choung, P.H., Seo, B.M., Chung, C.P., Yamada, K.M., Jang, J.H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  42. Effects of acidic and basic fibroblast growth factors (aFGF, bFGF) on glial precursor cell proliferation: age dependency and brain region specificity. Engele, J., Bohn, M.C. Dev. Biol. (1992) [Pubmed]
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