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Gene Review

FGF20  -  fibroblast growth factor 20

Homo sapiens

Synonyms: FGF-20, Fibroblast growth factor 20, RHDA2
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Disease relevance of FGF20


High impact information on FGF20


Chemical compound and disease context of FGF20


Biological context of FGF20


Anatomical context of FGF20


Other interactions of FGF20

  • Human FGF20 gene was linked to EFHA2 gene in head-to-head manner with an interval of about 25 kb [2].
  • Phylogenic analysis indicated that FGF-20, FGF-9, and FGF-16 constitute a subfamily among the FGF family [3].
  • Whereas FGF-20 promoted cell multiplication at low doses, FGF-19 was required at high doses to achieve a comparable effect [7].

Analytical, diagnostic and therapeutic context of FGF20


  1. FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. Chamorro, M.N., Schwartz, D.R., Vonica, A., Brivanlou, A.H., Cho, K.R., Varmus, H.E. EMBO J. (2005) [Pubmed]
  2. Comparative genomics on FGF20 orthologs. Katoh, M., Katoh, M. Oncol. Rep. (2005) [Pubmed]
  3. Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22. Kirikoshi, H., Sagara, N., Saitoh, T., Tanaka, K., Sekihara, H., Shiokawa, K., Katoh, M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  4. Preclinical characterization of CG53135 (FGF-20) in radiation and concomitant chemotherapy/radiation-induced oral mucositis. Alvarez, E., Fey, E.G., Valax, P., Yim, Z., Peterson, J.D., Mesri, M., Jeffers, M., Dindinger, M., Twomlow, N., Ghatpande, A., LaRochelle, W.J., Sonis, S.T., Lichenstein, H.S. Clin. Cancer Res. (2003) [Pubmed]
  5. Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. Takagi, Y., Takahashi, J., Saiki, H., Morizane, A., Hayashi, T., Kishi, Y., Fukuda, H., Okamoto, Y., Koyanagi, M., Ideguchi, M., Hayashi, H., Imazato, T., Kawasaki, H., Suemori, H., Omachi, S., Iida, H., Itoh, N., Nakatsuji, N., Sasai, Y., Hashimoto, N. J. Clin. Invest. (2005) [Pubmed]
  6. Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease. van der Walt, J.M., Noureddine, M.A., Kittappa, R., Hauser, M.A., Scott, W.K., McKay, R., Zhang, F., Stajich, J.M., Fujiwara, K., Scott, B.L., Pericak-Vance, M.A., Vance, J.M., Martin, E.R. Am. J. Hum. Genet. (2004) [Pubmed]
  7. Effects of fibroblast growth factors 19 and 20 on cell multiplication and locomotion in a human embryonal carcinoma cell line (Tera-2) in vitro. Engstr??m, W., Granerus, M. Anticancer Res. (2006) [Pubmed]
  8. A specific survival response in dopamine neurons at most risk in Parkinson's disease. Murase, S., McKay, R.D. J. Neurosci. (2006) [Pubmed]
  9. Comparative genomics on FGF8, FGF17, and FGF18 orthologs. Katoh, M., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
  10. FGF signaling network in the gastrointestinal tract (review). Katoh, M., Katoh, M. Int. J. Oncol. (2006) [Pubmed]
  11. Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis. Jeffers, M., Shimkets, R., Prayaga, S., Boldog, F., Yang, M., Burgess, C., Fernandes, E., Rittman, B., Shimkets, J., LaRochelle, W.J., Lichenstein, H.S. Cancer Res. (2001) [Pubmed]
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