Disease relevance of Ppp6c

• PP6, a representative of the first group, recognizes an epitope shared by smooth-type Bordetella parapertussis and Bordetella bronchiseptica lipopolysaccharides (LPS) [1].

High impact information on Ppp6c

• We measured in rat aorta rings the relaxant activity of a number of peptides derived from the activating sequence (SLIGRL, or PP6) of the proteinase-activated receptor-2 (PAR-2) [2].
• 6. The contractile actions of PP6 and PP6-NH2 in the rat gastric preparation required the presence of extracellular calcium, were inhibited by nifedipine and were blocked by the cyclo-oxygenase inhibitor, indomethacin and by the tyrosine kinase inhibitor, genistein, but not by the kinase C inhibitor, GF109203X [3].
• Between days 2-7 post-transplant, both allogenic fibroblasts and PP6 myogenic stem cells maintained survivability in similar numbers [4].
• Outside the pancreas, no localizations were obtained with anti-hPP antiserum, whereas antiserum to PP6 demonstrated immunoreactivity in a variety of tissues including gut glucagon cells, adrenal chromaffin cells, and nerve fibres in the gastrointestinal tract and adrenal gland [5].
• The protein serine/threonine phosphatase (PP) type 2A family consists of three members: PP2A, PP4, and PP6 [6].

Biological context of Ppp6c

• PP2A, PP4, and PP6 catalytic subunits (PP2A(C), PP4(C), and PP6(C), respectively) were detected in all rat tissue extracts examined and exhibited some differences in their levels of expression [6].

References