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PPP6C  -  protein phosphatase 6, catalytic subunit

Homo sapiens

Synonyms: PP6, PP6C, PPP6, Serine/threonine-protein phosphatase 6 catalytic subunit
 
 
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Disease relevance of PPP6C

  • Six monoclonal antibodies (mAbs) against lipopolysaccharides (LPS) from Bordetella pertussis (P1P3, 60.5), B. parapertussis (PP2, PP6, PPB) and B. bronchiseptica (BRg1) were used to examine the presence of antigenic determinants of LPS on B. bronchiseptica cells [1].
  • In particular the neurofilament protein (NFP)68 kDa, PP1 and PP6 showed significant differences of reactivity between pineocytoma, Int-PPT and pineoblastoma, when compared in groups showing extensive positive staining (positive staining in almost all areas of the tumor) [2].
  • In retinoblastomas, PP5 antibody, which reacts with horizontal cells and ganglion cells, and PP6 antibody, which reacts with part of the bipolar cells in the inner nuclear layer, showed intense staining in well-differentiated retinoblastomas, but the intensity of staining and the positivity decreased with the degree of dedifferentiation [3].
 

High impact information on PPP6C

 

Biological context of PPP6C

 

Anatomical context of PPP6C

 

Associations of PPP6C with chemical compounds

  • Novel serine/threonine phosphatases--PP4 and PP6 in human cells--have been discovered recently, for which regulatory subunits are yet to be identified [12].
 

Other interactions of PPP6C

References

  1. Antigenic polymorphism of the lipopolysaccharides from human and animal isolates of Bordetella bronchiseptica. Le Blay, K., Gueirard, P., Guiso, N., Chaby, R. Microbiology (Reading, Engl.) (1997) [Pubmed]
  2. Immunohistochemical characterization of pineal parenchymal tumors using novel monoclonal antibodies to the pineal body. Yamane, Y., Mena, H., Nakazato, Y. Neuropathology : official journal of the Japanese Society of Neuropathology. (2002) [Pubmed]
  3. Immunohistochemical localization of human pineal tissue antigens in normal retina and retinoblastomas. Sawai, J., Nakazato, Y., Yamane, Y., Kimura, N., Kishi, S. Neuropathology : official journal of the Japanese Society of Neuropathology. (2003) [Pubmed]
  4. The role of Ppe1/PP6 phosphatase for equal chromosome segregation in fission yeast kinetochore. Goshima, G., Iwasaki, O., Obuse, C., Yanagida, M. EMBO J. (2003) [Pubmed]
  5. Protein Phosphatase 6 Down-regulates TAK1 Kinase Activation in the IL-1 Signaling Pathway. Kajino, T., Ren, H., Iemura, S., Natsume, T., Stefansson, B., Brautigan, D.L., Matsumoto, K., Ninomiya-Tsuji, J. J. Biol. Chem. (2006) [Pubmed]
  6. The {alpha}4 Regulatory Subunit Exerts Opposing Allosteric Effects on Protein Phosphatases PP6 and PP2A. Prickett, T.D., Brautigan, D.L. J. Biol. Chem. (2006) [Pubmed]
  7. Primary structure and gene localization of human prolidase. Endo, F., Tanoue, A., Nakai, H., Hata, A., Indo, Y., Titani, K., Matsuda, I. J. Biol. Chem. (1989) [Pubmed]
  8. Localization of the novel serine/threonine protein phosphatase 6 gene (PPP6C) to human chromosome Xq22.3. Bastians, H., Krebber, H., Vetrie, D., Hoheisel, J., Lichter, P., Ponstingl, H., Joos, S. Genomics (1997) [Pubmed]
  9. Expression of AIE-75 PDZ-domain protein induces G2/M cell cycle arrest in human colorectal adenocarcinoma SW480 cells. Hirai, A., Tada, M., Furuuchi, K., Ishikawa, S., Makiyama, K., Hamada, J., Okada, F., Kobayashi, I., Fukuda, H., Moriuchi, T. Cancer Lett. (2004) [Pubmed]
  10. Identification of a type 6 protein ser/thr phosphatase regulated by interleukin-2 stimulation. Filali, M., Li, S., Kim, H.W., Wadzinski, B., Kamoun, M. J. Cell. Biochem. (1999) [Pubmed]
  11. The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation. Bastians, H., Ponstingl, H. J. Cell. Sci. (1996) [Pubmed]
  12. Alpha 4 associates with protein phosphatases 2A, 4, and 6. Chen, J., Peterson, R.T., Schreiber, S.L. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
 
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